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Illoldi-Rangel P.,University of Texas at Austin | Rivaldi C.-L.,University of Texas at Austin | Sissel B.,University of Texas at Austin | Trout Fryxell R.,University of California at Davis | And 6 more authors.
Journal of Tropical Medicine | Year: 2012

Species distribution models were constructed for ten Ixodes species and Amblyomma cajennense for a region including Mexico and Texas. The model was based on a maximum entropy algorithm that used environmental layers to predict the relative probability of presence for each taxon. For Mexico, species geographic ranges were predicted by restricting the models to cells which have a higher probability than the lowest probability of the cells in which a presence record was located. There was spatial nonconcordance between the distributions of Amblyomma cajennense and the Ixodes group with the former restricted to lowlands and mainly the eastern coast of Mexico and the latter to montane regions with lower temperature. The risk of Lyme disease is, therefore, mainly present in the highlands where some Ixodes species are known vectors; if Amblyomma cajennense turns out to be a competent vector, the area of risk also extends to the lowlands and the east coast. Copyright 2012 Patricia Illoldi-Rangel et al.


Feria-Arroyo T.P.,University of Texas–Pan American | Castro-Arellano I.,Texas State University | Gordillo-Perez G.,Centro Medico Nacional SXXI | Cavazos A.L.,University of Texas–Pan American | And 6 more authors.
Parasites and Vectors | Year: 2014

Background: Disease risk maps are important tools that help ascertain the likelihood of exposure to specific infectious agents. Understanding how climate change may affect the suitability of habitats for ticks will improve the accuracy of risk maps of tick-borne pathogen transmission in humans and domestic animal populations. Lyme disease (LD) is the most prevalent arthropod borne disease in the US and Europe. The bacterium Borrelia burgdorferi causes LD and it is transmitted to humans and other mammalian hosts through the bite of infected Ixodes ticks. LD risk maps in the transboundary region between the U.S. and Mexico are lacking. Moreover, none of the published studies that evaluated the effect of climate change in the spatial and temporal distribution of I. scapularis have focused on this region. Methods. The area of study included Texas and a portion of northeast Mexico. This area is referred herein as the Texas-Mexico transboundary region. Tick samples were obtained from various vertebrate hosts in the region under study. Ticks identified as I. scapularis were processed to obtain DNA and to determine if they were infected with B. burgdorferi using PCR. A maximum entropy approach (MAXENT) was used to forecast the present and future (2050) distribution of B. burgdorferi-infected I. scapularis in the Texas-Mexico transboundary region by correlating geographic data with climatic variables. Results: Of the 1235 tick samples collected, 109 were identified as I. scapularis. Infection with B. burgdorferi was detected in 45% of the I. scapularis ticks collected. The model presented here indicates a wide distribution for I. scapularis, with higher probability of occurrence along the Gulf of Mexico coast. Results of the modeling approach applied predict that habitat suitable for the distribution of I. scapularis in the Texas-Mexico transboundary region will remain relatively stable until 2050. Conclusions: The Texas-Mexico transboundary region appears to be part of a continuum in the pathogenic landscape of LD. Forecasting based on climate trends provides a tool to adapt strategies in the near future to mitigate the impact of LD related to its distribution and risk for transmission to human populations in the Mexico-US transboundary region. © 2014 Feria-Arroyo et al.; licensee BioMed Central Ltd.


Esteve-Gassent M.D.,Texas A&M University | Grover A.,Texas A&M University | Feria-Arroyo T.P.,University of Texas–Pan American | Castro-Arellano I.,Texas State University | And 3 more authors.
Parasites and Vectors | Year: 2015

In a recent Letter to the Editor, Norris et al. questioned the validity of some of our data reported by Feria-Arroyo et al. The main issue investigated by us was the potential impact of climate change on the probable distribution of the tick vector Ixodes scapularis in the Texas-Mexico transboundary region. As an ancillary issue, an analysis of sequence data for the intergenic spacer of Borrelia burgdorferi was conducted. In the present letter, we provide further evidence supporting our original results, and advocate that extensive study of the population genetics of B. burgdorferi is needed in the Texas-Mexico transboundary region. © 2015 Esteve-Gassent et al.; licensee BioMed Central.


PubMed | U.S. Department of Agriculture, University of Texas–Pan American, Texas State University, Centro Medico Nacional SXXI and Texas A&M University
Type: | Journal: Parasites & vectors | Year: 2015

In a recent Letter to the Editor, Norris et al. questioned the validity of some of our data reported by Feria-Arroyo et al. The main issue investigated by us was the potential impact of climate change on the probable distribution of the tick vector Ixodes scapularis in the Texas-Mexico transboundary region. As an ancillary issue, an analysis of sequence data for the intergenic spacer of Borrelia burgdorferi was conducted. In the present letter, we provide further evidence supporting our original results, and advocate that extensive study of the population genetics of B. burgdorferi is needed in the Texas-Mexico transboundary region.


Ramirez-Torres N.,Umae Del Hospital Of Ginecologia Y Obstetricia | Moctezuma-Meza C.,Umae Del Hospital Of Ginecologia Y Obstetricia | Asbun-Bojalil J.,Seccion Posgrado | Valenzuela-Martinez L.A.,Umae Del Hospital Of Ginecologia Y Obstetricia | And 8 more authors.
Gaceta Mexicana de Oncologia | Year: 2015

Objective: Retrospective study, designed to assess the effectiveness and tolerability of docetaxel sequential to epirubicin as neoadjuvant systemic therapy (NST) in women with locally advanced breast cancer (LABC). Patients and Methods: A total of 126 LABC-diagnosed patients were included (70 stage IIIA; 53 stage IIIB; 3 stage IIIC). The patients received FEC (500 mg/m2, 75 mg/m2, 500 mg/m2, respectively) every 3 weeks for 4 cycles, followed by docetaxel 75 mg/m2 every 3 weeks for 4 cycles. Surgery was performed at the end of the chemotherapy. Results: In the analysis of the 4FEC-4D scheme by groups, a significant increase in clinical complete response (cCR) was observed when docetaxel was added to preoperative FEC (Wilcoxon test, z = -2.35; P =.019). An objective response rate (ORR) of 78.5% (95% confidence interval [95% CI], 71.4 - 85.7) and pathological complete response (pCR) of 30.2% (95% CI, 22.2 - 38.2) were obtained. In the pCR group, tumors with stage IIIA lower nuclear grade and ER-positiveness showed higher response to NST (71.1%, 84.2% and 61.7%, respectively). The proportion of patients with negative lymph nodes was 51.6%. (95% CI: 42.9 - 60.3). The FEC regimen had more severe emetic effects, such as nausea (3.3%) and vomiting (2.1%). The docetaxel regimen produced severe toxicities, including myalgia (2.0%), fatigue (1.4%), and peripheral sensory neuropathy (0.4%). Conclusion: This study showed that the sequential addition of standard-dose docetaxel to FEC is highly active, feasible and well tolerated in patients with LABC. © 2015, Sociedad Mexicana de Oncología.


Rojas-Dotor S.,Hospital Of Pediatria | Segura-Mendez N.H.,Centro Medico Nacional SXXI | Miyagui-Namikawa K.,Centro Medico Nacional SXXI | Mondragon-Gonzalez R.,Centro Medico Nacional SXXI
Biological Research | Year: 2013

Asthma studies suggest that alteration in the inflammation pattern may be associated with the severity of asthma. The aim of this study was to compare in vitro the expression of chemokines, chemokine receptors and cytokine production from CD4+ T human lymphocytes of asthmatic, both obese and non-obese patients with different severity levels of asthma. Lymphocytes were labeled with monoclonal anti-human CXCR3/IP-10, MIP-1α/CCR5 antibodies and were analyzed by flow cytometry. Cell culture supernatants were used to measure production of interleukin IL-6 and resistin by ELISA. CXCR3/IP-10 expression increased in non-obese patients with mild persistent asthma (2.2%, p<0.05), moderate persistent asthma (3%, p<0.003) and severe persistent asthma (4%, p<0.004); this effect was stronger in obese patients with severe persistent asthma (35%, p<0.004). MIP-1 α / CCR5 increased in non-obese patients with intermittent asthma (0.65%, p<0.05) and severe asthma (1.4%, p<0.03); in obese patients, this expression was greater in intermittent asthma (8%, p<0.05) and severe persistent asthma (12%, p<0.04). Resistin production strongly increased in obese patients with intermittent (976 ng/ml) and severe persistent asthma (795 ng/ml). IL-6 increased in both lean and obese persons; however, the highest value was registered in the group of severe persistent obese asthmatics (992 pg/ml). Obesity per se increased the inflammatory profile of chemokines / cytokines secreted by cells of the blood, increasing the inflammatory status in asthmatic patients. Resistin showed characteristics of a pro-inflammatory cytokine mainly in severely obese asthmatics.

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