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Ex-Hacienda el Hospital, Mexico

Galvez-Romero G.,Centro Medico Nacional Siglo XXI and IMSS | Galvez-Romero G.,National Autonomous University of Mexico | Salas-Rojas M.,Centro Medico Nacional Siglo XXI and IMSS | Salas-Rojas M.,National Autonomous University of Mexico | And 3 more authors.
Fish and Shellfish Immunology | Year: 2011

Antiviral activity (99.5% inhibition) against the Autographa californica polyhedrosis nuclear virus AcNPV+GFP was shown by a polypeptide of approximately 10 kDa, isolated from the exoskeleton of Pleuroncodes planipes, the pelagic red crab. This thermo-stable polypeptide retained its anti-viral properties after being exposed to 76 °C for 30 min and showed no apparent cytotoxic effect. Its anti-viral activity was observed when incubated with the virus, previous to the inoculation of cells. Using Tandem Mass Spectrometry (LC/ESI-MS/MS), this polypeptide showed sequence identity to a fragment of a myohemeritrin-like metalloprotein found in the Scoloplos armiger sea worm (VFYANLDEEHK). © 2011 Elsevier Ltd.

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