Centro Medico Nacional IMSS

Mexico City, Mexico

Centro Medico Nacional IMSS

Mexico City, Mexico
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Perez T.,National Polytechnic Institute of Mexico | Farfan-Garcia E.D.,National Polytechnic Institute of Mexico | Soriano-Ursua M.A.,National Polytechnic Institute of Mexico | Manuel-Apolinar L.,Centro Medico Nacional IMSS | And 6 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2017

Background: The effect of oxidative stress promotes activity enzymatic in vascular wall that produces hydrogen peroxide with the effect on endothelium and the development of cardiovascular diseases. Aims: We evaluated the effect of hydrogen peroxide on vascular function in thoracic and abdominal aorta. Methods: Under basal conditions, 3- and 6-month-old rats had similar blood pressure, but age- and aortic segment-dependent differences in other parameters. Results: In abdominal aorta of 6-month-old rats, superoxide dismutase activity was unchanged but there was a decrease in catalase activity, nitric oxide concentration and the phenylephrine-induced contraction. This diminished phenylephrine response was similar when adding H2O2, later restored by L-NAME or Wortmannin. Moreover, p-Akt expression increased in 6-month-old rats after adding H2O2. In thoracic aorta of 6-month-old rats, antioxidant activity increased. No differences were found in 3- or 6-month-old rats regarding the response to Ach or Phe in this aortic segment. In conclusion, in this study we found that H2O2 plays a key role in the modified endothelium-dependent response to phenylephrine (through PI3K/Akt/NO mechanisms) in the abdominal aorta of normotensive rats. The results were different in thoracic aorta.


Mendoza-Pinto C.,systemIC | Garcia-Carrasco M.,systemIC | Garcia-Carrasco M.,Autonomous University of Puebla | Jimenez-Hernandez M.,systemIC | And 4 more authors.
Autoimmunity Reviews | Year: 2010

Bechet's disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes, skin, joints, etc., which produces various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown, although immunological abnormalities, possibly induced by susceptible microbiological pathogens, have been postulated. © 2009.

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