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Camprecios G.,University of Barcelona | Sanchez-Vizcaino E.,Centro Internacional Of Medicina Avanzada | Soley M.,University of Barcelona | Ramirez I.,University of Barcelona
Growth Factors | Year: 2011

Although the sympathetic nervous system is involved in injury caused to the kidney by several stressors such as hypertension or ischemia/reperfusion, little is known about the effect of chronic adrenergic stimulation in the kidneys. Upon injury, however, the kidney possesses a high capacity for tubular cell regeneration and functional recovery. The ErbB1 receptor and its ligands play an essential role in this process. We studied the effects of chronic isoproterenol (ISO) administration (β-adrenoceptor agonist) in the mouse kidney. ISO induced a moderate and reversible loss of kidney weight and protein content that was not associated with renal dysfunction. We observed an increase in tubular cell proliferation (bromodeoxyuridine labeling) in ISO-treated mice in both the outer and inner cortex. ErbB1 (epidermal growth factor receptor) along with ErbB2 and ErbB3 (neuregulin receptor) were transiently overexpressed in ISO-treated mice, with an increase in protein but not mRNA content. All receptors were localized in the same nephron segments and cell types. Immunoprecipitation studies after epidermal growth factor or neuregulin-1β stimulation showed dynamic interaction of all four ErbB receptors. Therefore, we conclude that ErbB receptors may cooperate in the response to chronic β-adrenergic stimulation. © 2011 Informa UK, Ltd. Source


Dominguez-Ortega J.,Hospital Universitario Of Getafe | Quirce S.,Hospital Universitario La Paz | Delgado J.,Hospital Virgen Macarena | Davila I.,Hospital Universitario Of Salamanca | And 2 more authors.
Allergologia et Immunopathologia | Year: 2014

Background: There are few studies which analyse the characteristics of allergic respiratory disease according to profiles of sensitisation to different allergens. This study describes the clinical features and therapeutic approaches, according to the sensitisation profile to relevant aeroallergens, in a sample of adult patients with a first-time diagnosis of respiratory allergy (rhinitis and/or asthma). Methods: 1287 patients, enrolled consecutively in the spring of 2010 by 200 allergy specialists, were classified into four groups according to sensitisation to significant allergens in each geographical area (grass pollen, olive pollen, grass and olive pollen, house dust mites). Information was obtained on demographics, diagnostic procedures used, treatments prescribed, clinical characteristics of the rhinitis, and severity and control of asthma. Results: Of the patients, 58.6% had rhinitis only and 38.7% had both rhinitis and asthma. Patients with more severe rhinitis had more severe and poorer controlled asthma. Sensitisation to different allergens was not associated with significant differences in severity and control of asthma, but patients with house dust mite allergy presented persistent rhinitis more frequently. Allergy to grass pollen was significantly associated with food allergies. Differences were observed in the frequency of prescription of immunotherapy and antileukotrienes in patients allergic to house dust mites and of topical corticosteroids in patients with pollen allergy. Conclusions: It was observed in this study that in respiratory allergy disease, there are clinical differences as well as differences in diagnostic procedure and therapeutic attitudes, depending on the clinically relevant allergen. © 2012 SEICAP. Source


Munoz-Ortego J.,CIMA | Munoz-Ortego J.,Centro Internacional Of Medicina Avanzada | Munoz-Ortego J.,International University of Catalonia | Marco-Aznar P.,International University of Catalonia
Revista Internacional de Acupuntura | Year: 2012

Advanced diagnostic criteria (ADC) arose from the classical concept of Bi described in traditional Chinese medicine. The establishment of ADC allows rheumatological diseases to be approached with greater rigor, clarity and depth. To achieve this, the systemic alteration underlying the specific painful joint manifestations must be identified. Consequently, global and specific ADC are needed. Global ADC emphasize the physiopathogenesis of the internal alterations that encourage the development of rheumatic manifestations and, above all, their persistence, a characteristic of the chronic nature of these diseases. Specific ADC aim to identify and define the manifestations of pain -the main reason for consultations- in the distinct osteomuscular structures involved. These ADC allow interpretation of rheumatic diseases, consensus on diagnoses, and optimization of acupuncture as a medical procedure. Source


Sanchez-Vizcaino E.,University of Barcelona | Sanchez-Vizcaino E.,Centro Internacional Of Medicina Avanzada | Vehi C.,Centro Internacional Of Medicina Avanzada | Camprecios G.,University of Barcelona | And 3 more authors.
Growth Factors | Year: 2010

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the EGF family of growth factors which are ligands of the ErbB receptors. Studies in animals suggest the role of HB-EGF in several pathogenic processes such as atherosclerosis and heart hypertrophy. Here, we set up an assay to measure HB-EGF in human serum. Our ELISA determined serum HB-EGF in the range of 0.033 nM. It did not cross-react with EGF or with transforming growth factor-α. The mean serum HB-EGF was 0.26 nM (confidence interval: 0.130.39) in women and 0.28 nM (confidence interval: 0.090.47) in men. In a cohort of 121 healthy volunteers, we identified nine individuals with high serum HB-EGF (above 0.47 nM). These individuals had higher left ventricle mass (determined by Colour Doppler echocardiography) and greater total and low density lipoprotein cholesterol than control. On the basis of our results, we propose that increased serum HB-EGF is associated with heart hypertrophy and elevated blood cholesterol. © 2010 Informa UK Ltd. Source

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