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Cazzola M.,Polytechnic University of Turin | Corazzari I.,University of Turin | Corazzari I.,Centro Interdipartimentale G Scansetti Per Lo Studio Degli Amianti E Of Altri Particolati Nocivi | Prenesti E.,University of Turin | And 3 more authors.
Applied Surface Science | Year: 2016

Polyphenols are actually achieving an increasing interest due to their potential health benefits, such as antioxidant, anticancer, antibacterial and bone stimulation abilities. However their poor bioavailability and stability hamper an effective clinical application as therapeutic principles. The opportunity to couple these biomolecules with synthetic biomaterials, in order to obtain local delivery at the site of interest, improve their bioavailability and stability and combine their properties with the ones of the substrate, is a challenging opportunity for the biomedical research. A silica based bioactive glass, CEL2, has been successfully coupled with gallic acid and natural polyphenols extracted from red grape skins and green tea leaves. The effectiveness of grafting has been verified by means of XPS analyses and the Folin&Ciocalteu tests. In vitro bioactivity has been investigated by soaking in simulated body fluid (SBF). Surface modification after functionalization and early stage reactivity in SBF have been studied by means of zeta potential electrokinetic measurements in KCl and SBF. Finally the antioxidant properties of bare and modified bioactive glasses has been investigated by means of the evaluation of free radical scavenging activity by Electron Paramagnetic Resonance (EPR)/spin trapping technique after UV photolysis of H2O2 highlighting scavenging activity of the bioactive glass. © 2016 Elsevier B.V. All rights reserved.

Ferraris S.,Polytechnic University of Turin | Zhang X.,Polytechnic University of Turin | Prenesti E.,University of Turin | Corazzari I.,University of Turin | And 6 more authors.
Journal of Non-Crystalline Solids | Year: 2015

Ferrimagnetic bioactive glass ceramics are promising biomaterials in the field of bone substitution and cancer treatment for their ability to bond to bone (bioactive behavior) and to be heated by the application of an external magnetic field (hyperthermia). Surface functionalization of these materials with polyphenols is a challenging and innovative strategy in order to impart them additional functional and specific properties (e.g. antioxidant, anticancer and antibacterial). Gallic acid (GA) is a phenolic acid which can be considered a good model molecule for polyphenols due to its simple structure and representative properties. In the present paper GA has been grafted to a ferrimagnetic glass ceramic (SC-45), in bulk and powder forms, in view of its potential clinical applications (such as hyperthermic treatment of cancer combined with the anticancer action of GA). The grafting process has been optimized in order to preserve GA activity. The effectiveness of the functionalization procedure has been demonstrated by means of Scanning Electron Microscopy equipped with Energy Dispersive Spectroscopy (SEM-EDS), X-ray Photoelectron Spectroscopy (XPS), Thermogravimetric analysis-gas evolved analysis (TGA-EGA) and Folin&Ciocalteu tests (F&C). Release tests have been performed in double distilled water at 37. °C and 43. °C to verify the stability of the material. © 2015 Elsevier B.V.

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