Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria

Póvoa de Santa Iria, Portugal

Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria

Póvoa de Santa Iria, Portugal

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Silva A.,Centro Hospital iversitario Of Coimbra | Amorim A.,Centro Hospitalar Of Sao Joao | Azevedo P.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Lopes C.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Gamboa F.,Centro Hospital iversitario Of Coimbra
Revista Portuguesa de Pneumologia | Year: 2016

Introduction: The incidence of cystic fibrosis (CF) in Portugal is estimated at 1:8000 live births, although there is a lack of accurate statistics. The average life expectancy has been steadily increasing and CF is no longer an exclusively pediatric disease. Objectives: Characterize the Portuguese adult population with the diagnosis of CF. Methods: Retrospective study based on clinical data of adult CF follow-up patients in the three specialized centers in Portugal where all of CF patients are seen, during 2012. Results: In 2012, there were 89 follow-up patients, 48 (54%) female and 15 (17%) lung transplanted. The average age was 31.3 ± 9 years. The median age at diagnosis was 13 years and 34 (38%) were diagnosed in adulthood. The most frequent mutation was F508del (54.9%). Of the 89 patients, 49 patients (56%) had pancreatic insufficiency, 7 (9%) were diabetic and 42 patients (47.7%) had a body mass index (BMI) <20 kg/m2. As to ventilatory function, the average value of the forced expiratory volume in 1 s (FEV1) was 58.45 ± 28.59%. Only one of 77 patients did not have chronic airway infection. The most commonly isolated germ was methicillin-sensitive Staphylococcus aureus in 49 patients (55%). During 2012, two patients (2.2%) died at the ages of 21 and 36 years. Discussion: This study is the first description of the Portuguese adult CF population, which is particularly important since it can give us a better understanding of the real situation. A significant percentage of these patients were diagnosed in adulthood, which highlights the need for diagnostic suspicion in a patient with chronic lung disease and atypical manifestations. © 2016 Sociedade Portuguesa de Pneumologia.


PubMed | Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria, Centro Hospitalar Of Sao Joao and Centro Hospital iversitario Of Coimbra
Type: Journal Article | Journal: Revista portuguesa de pneumologia | Year: 2016

The incidence of cystic fibrosis (CF) in Portugal is estimated at 1:8000 live births, although there is a lack of accurate statistics. The average life expectancy has been steadily increasing and CF is no longer an exclusively pediatric disease.Characterize the Portuguese adult population with the diagnosis of CF.Retrospective study based on clinical data of adult CF follow-up patients in the three specialized centers in Portugal where all of CF patients are seen, during 2012.In 2012, there were 89 follow-up patients, 48 (54%) female and 15 (17%) lung transplanted. The average age was 31.39 years. The median age at diagnosis was 13 years and 34 (38%) were diagnosed in adulthood. The most frequent mutation was F508del (54.9%). Of the 89 patients, 49 patients (56%) had pancreatic insufficiency, 7 (9%) were diabetic and 42 patients (47.7%) had a body mass index (BMI) <20kg/m(2). As to ventilatory function, the average value of the forced expiratory volume in 1s (FEV1) was 58.4528.59%. Only one of 77 patients did not have chronic airway infection. The most commonly isolated germ was methicillin-sensitive Staphylococcus aureus in 49 patients (55%). During 2012, two patients (2.2%) died at the ages of 21 and 36 years.This study is the first description of the Portuguese adult CF population, which is particularly important since it can give us a better understanding of the real situation. A significant percentage of these patients were diagnosed in adulthood, which highlights the need for diagnostic suspicion in a patient with chronic lung disease and atypical manifestations.


PubMed | University of Porto, Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria, Centro Hospitalar Of Sao Joao and University of Coimbra
Type: | Journal: Revista portuguesa de pneumologia | Year: 2016

Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians. Although most cases are diagnosed in childhood, diagnosis in adults is apparently increasing.Evaluate the adult population with CF, comparing patients who were diagnosed before and after 18 years of age.Retrospective analysis of patients followed in three main medical centres in Portugal in 2012. Comparison of two groups: G1 - patients diagnosed at <18 years and G2 - patients diagnosed at 18 years.89 adults were identified: 61.8% in G1, 38.2% in G2. Gender distribution was similar in both groups. Average age in G2 was higher (38.38.4 vs. 26.86.1 years, p<0.001). Respiratory symptoms most frequently led to CF diagnosis in all patients, mainly in adulthood. There was a greater percentage of patients homozygous for the mutation delF508 in G1 (43.6 vs. 8.8%, p=0.02). Respiratory and pancreatic function, and body mass index (BMI) showed a higher severity in G1 (G1 vs. G2: FEV1: 54.627.3 vs. 29.964.6%, p=0.177; pancreatic insufficiency 72.7 vs. 26.5%, p<0.001; BMI 20.23.4 vs. 22.24.8, p=0.018). Pseudomonas aeruginosa and methicillin-sensitive Staphylococcus aureus were the most frequently isolated microorganisms. Lung transplantation rate was higher in G2 (20.6 vs. 10.9%, p=0.231) while mortality rate was higher in G1 (0 vs. 3.6%, p=0.261). Hospital admission rate was higher in G1 as well as mortality rate.The results suggest that patients with CF diagnosed in childhood have characteristics that distinguish them from those diagnosed in adulthood, and these differences may have implications for diagnosis, prognosis and life expectancy.


Castro C.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Afonso M.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Carvalho R.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Clode N.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria | Graca L.M.,Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria
Archives of Gynecology and Obstetrics | Year: 2014

Methods: In a randomized controlled trial, patients with singleton, cephalic, term, and low-risk pregnancy were assigned to either vaginal intercourse at least twice a week or abstinence. The following data were assessed: demographics, parity, vaginal coitus frequency before and during pregnancy, Bishop score at 38th weeks, gestational age at delivery, mode of delivery, and days between recruitment and delivery. The primary outcome was spontaneous labor onset.Objective: This study aimed at evaluating the effect of vaginal intercourse on spontaneous labor onset at term.Results: Of the 123 patient analyzed, 63 were assigned to study group and 60 to control group. Mean interval between study recruitment and delivery was higher in sexually active women (15.05 days ± 0.8 compared with 14.17 days ± 0.8, p = 0.45) as well as the rate of cesarean delivery (14.3 % compared with 10 %, p = 0.58), but the differences were not statistically significant. The rate of spontaneous labor was similar in both groups (84.1 % in vaginal coitus group; 75 % in control group, p = 0.26).Conclusion: Our results showed that vaginal intercourse does not hasten spontaneous labor onset at term. © 2014, Springer-Verlag Berlin Heidelberg.


PubMed | Centro Hospitalar Of Lisbon Norte Hospital Of Santa Maria
Type: Journal Article | Journal: Archives of gynecology and obstetrics | Year: 2014

This study aimed at evaluating the effect of vaginal intercourse on spontaneous labor onset at term.In a randomized controlled trial, patients with singleton, cephalic, term, and low-risk pregnancy were assigned to either vaginal intercourse at least twice a week or abstinence. The following data were assessed: demographics, parity, vaginal coitus frequency before and during pregnancy, Bishop score at 38th weeks, gestational age at delivery, mode of delivery, and days between recruitment and delivery. The primary outcome was spontaneous labor onset.Of the 123 patient analyzed, 63 were assigned to study group and 60 to control group. Mean interval between study recruitment and delivery was higher in sexually active women (15.05 days 0.8 compared with 14.17 days 0.8, p = 0.45) as well as the rate of cesarean delivery (14.3 % compared with 10 %, p = 0.58), but the differences were not statistically significant. The rate of spontaneous labor was similar in both groups (84.1 % in vaginal coitus group; 75 % in control group, p = 0.26).Our results showed that vaginal intercourse does not hasten spontaneous labor onset at term.

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