Centro Hospitalar Of Lisbon Central Epe Lisbon

Lisbon, Portugal

Centro Hospitalar Of Lisbon Central Epe Lisbon

Lisbon, Portugal
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Neves B.,Hospital da Luz Lisbon | Raimundo P.,Hospital da Luz Lisbon | Farinha P.,Centro Hospitalar Of Lisbon Central Epe Lisbon
BMJ Case Reports | Year: 2017

Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis. We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm 3 and viral load 3.172.370 copies/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman's disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved.

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