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Diniz R.P.H.,Centro Hospitalar do Medio Ave | Nascimento J.C.,University of Minho
2015 10th Iberian Conference on Information Systems and Technologies, CISTI 2015 | Year: 2015

ICT management is traditionally a complex area in the health sector. Significant investments have been made but related results are normally hard to find. In this context, the present research aims to study the process of implementation of Picture Archiving and Communication System (PACS) at Centro Hospitalar do Médio Ave, in order to understand the process of technology adoption in a hospital context and the analyze the related impacts. This study is based in an interpretative approach, supported by a qualitative research process in order to obtain and analyze relevant information that was gained from a qualified panel of experts, including both health and ITC professionals. © 2015 AISTI.

Antunes H.,Braga Hospital | Antunes H.,University of Minho | Rodrigues H.,Unidade Local de Saude do Alto Minho | Silva N.,Braga Hospital | And 5 more authors.
Journal of Clinical Virology | Year: 2010

Background: In 2006, bronchiolitis due to adenovirus nosocomial infections resulted in the closure of a pediatric department in northern Portugal. Objectives: To determine the etiology of bronchiolitis in northern Portugal. Study design: It was a prospective multicenter study on the etiology of bronchiolitis during the respiratory syncytial virus (RSV) season (November-April). Children ≤24 months of age admitted for a first wheezing episode were included. Nasopharyngeal specimens were analyzed by an indirect immunofluorescent-antibody assay (IFA) for RSV, adenovirus (HAdV), parainfluenza (PIV) 1-3 and influenza (IV) A and B and by polymerase chain reaction (PCR) or reverse transcription-PCR for the same viruses and for human metapneumovirus (hMPV), bocavirus (HBoV), rhinovirus (HRV), coronaviruses (229/E; NL63; OC43; HKU1) and enterovirus. Results: During this period, 253 children were included, 249 IFA analyses and 207 PCRs were performed. IFA detected RSV in 58.1%; PCR increased it to 66.7%. IFA detected HAdV in 3.2%, PCR 10.0%. PCR detected IV A in 5; IV B in 2; PIV 1 in 6, PIV 2 in 4 and PIV 3 in 11 cases. HBoV, as single agent in 2 cases, and HRV were positive in 8 samples and hMPV in 11. With this virus panel, 19.7% remained without etiology. Conclusions: The most frequent agent was RSV, followed by HAdV. PCR can be cost-effective and more accurate than IFA, which is crucial for HAdV that may be associated with significant mortality (IFA alone did not detect 2/3 of the cases). © 2010 Elsevier B.V. All rights reserved.

Marques A.M.,Centro Hospitalar do Medio Ave | Turner A.,University of Otago | De Mello R.A.,Portuguese Oncology Institute IPO PORTO | De Mello R.A.,University of Algarve
World Journal of Gastroenterology | Year: 2014

Metastatic colorectal cancer (mCRC) is still one of the tumor types with the highest incidence and mortality. In 2012, colorectal cancer was the second most prevalence cancer among males (9%) and the third among females (8%). In this disease, early diagnosis is important to improve treatment outcomes. However, at the time of diagnosis, about one quarter of patients already have metastases, and overall survival of these patients at 5-years survival is very low. Because of these poor statistics, the development of new drugs against specific targets, including the pathway of angiogenesis, has witnessed a remarkable increase. So, targets therapies through epidermal growth factor and its receptor and also KRAS pathways modulation acquired a main role whether in association with standard chemotherapy and radiotherapy. With the current knowledge in the field of molecular biology, including genetic mutations and polymorphisms, we know better why patients respond so differently to the same treatments. So, in the future we can develop increasingly personalized treatments to the patient and not the disease. This review aims to summarize some molecular pathways and their relation to tumor growth, as well as novel targeted developing drugs and recently approved for mCRC. © 2014 Baishideng Publishing Group Inc. All rights reserved.

Osorio L.,Domain Surgical | Silva D.,Domain Surgical | Silva D.,Centro Hospitalar do Medio Ave | Autorino R.,The Second University of Naples | And 3 more authors.
Urology | Year: 2011

Objective: To assess the feasibility of pure natural orifice transluminal endoscopic surgery (NOTES) transvesical venous ligation mimicking bilateral varicocelectomy in an animal model. Materials and Methods: Transvesical NOTES bilateral venous ligation was performed in 6 female pigs by considering lower epigastric vessels as a model for gonadal vessels. Under flexible cystoscopic guidance, a cystotomy was created on the anterior bladder. The flexible cystoscope was introduced through the over tube, and the lower epigastric vessels were visualized in retroflexion. Thulium laser was used to cut and coagulate the vessels. A bladder catheter was left in place for 4 days in all animals and they were sacrificed 15 days after the procedure. Results: The procedure was successfully carried out in all animals without intraoperative complications. Epigastric vessels were safely cut and coagulated using the thulium laser. Median time for the overall procedure, including establishment of the transvesical port, was 23 minutes (range 20-30). No complications were encountered during the postoperative follow-up period. Postmortem examination revealed complete coagulation and separation of vessels. Conclusion: An animal model mimicking a NOTES transvesical bilateral varicocelectomy procedure is successfully shown in the present study. Despite being encouraging, these novel findings need to be interpreted with caution. Further research is warranted and development of purpose-built instrumentation is awaited to define potential urological applications of transvesical NOTES. © 2011 Elsevier Inc. All Rights Reserved.

Temudo T.,Centro Materno Infantil do Norte | Temudo T.,Abel Salazar Biomedical Sciences Institute | Melo C.,Centro Hospitalar do Medio Ave | Melo C.,University of Porto
Journal of Pediatric Neurology | Year: 2015

Stereotypies are rhythmic, patterned, repetitive, purposeless, and continuous movements which may be categorized into the following two ways: primary, if they appear in healthy normally developing subjects; or secondary, when they are associated with neurologic problems. They may also be divided into motor, vocal, or visual stereotypies. Biological mechanisms of stereotypies are unknown but they seem to be related to the basal ganglia or the cortical-basal ganglia-thalamo-cortical circuits. Stereotypies are frequently found in patients with autistic disorders, intellectual disability, and sensorial deficit disorders. Some neurodevelopmental disorders show specific motor stereotypies, which reinforce the notion of a genetic or neurobiological basis. When necessary, treatment may include behavioral or drug-based approaches. Copyright © 2015 by Georg Thieme Verlag KG, Stuttgart, New York.

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