Villegas S.L.,Centro Internacional Of Entrenamiento E Investigaciones Medicas Cideim |
Villegas S.L.,Centro Colombiano Of Investigacion En Tuberculosis Ccit |
Villegas S.L.,Charite - Medical University of Berlin |
Ferro B.E.,Centro Internacional Of Entrenamiento E Investigaciones Medicas Cideim |
And 4 more authors.
Paediatrics and International Child Health
Background: There is a lack of uniform criteria for the diagnosis and management of tuberculosis (TB) in children in Cali, Colombia. Addressing TB in children is a challenge in this setting, under both programmatic and research conditions. Objectives: To facilitate the diagnostic assessment of TB in a paediatric cohort of TB household contacts. Methods: A diagnostic and management algorithm (DMA) was used to assess children exposed to adult TB cases, according to clinical and epidemiological findings and under programmatic conditions. On the basis of diagnostic tests, cases were classified as TB exposure, TB infection, suspected TB, possible TB or confirmed TB and then submitted to a management plan. This was a prospective pilot study nested within a national cohort study of the transmission dynamics of Mycobacterium tuberculosis, undertaken in Colombia during 2005-2008. Results: During 24 months of follow-up, 54 of 217 children met the criteria for assessment by DMA, 18 of whom (33%) were considered to be TB incident cases (new TB cases among household contacts). The main clinical findings were failure to thrive and cough lasting >21 days. Only one case was smear-positive and culture-confirmed TB. TB treatment was given to 16 children and they demonstrated clinical and radiographic resolution at follow-up. Conducting the study under programmatic conditions demonstrated barriers to accessing competent radiological evaluation, correct interpretation of the tuberculin skin test, and proper specimen collection. Conclusion: Structured assessment using DMA facilitated the detection of incident TB cases. The study identified potential barriers to addressing childhood TB in Cali. © W. S. Maney & Son Ltd 2014. Source