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Navarro-Carbonell D.E.,Laboratorio Of Ivf | Pulido-Torres C.,Ginecologia y Obstetricia | Saa-Madrinan A.M.,Laboratorio Of Ivf | Lucena-Quevedo E.,Centro Colombiano Of Fertilidad Y Esterilidad Cecolfes
Revista Colombiana de Obstetricia y Ginecologia | Year: 2012

Objective: Comparing embryo quality and describing implantation, pregnancy and abortion rates regarding in vitro fertilization (IVF) and intravaginal oocyte culture (INVO) techniques. Materials and methods: The study involved historical cohorts of patients undergoing IVF and INVO treatment in the Colombian Fertility and Sterility Centre (Centro Colombiano de Fertilidad y Esterilidad - Cecolfes) during 2010. It involved 137 aspirated patients, covering four study groups: Group 1 IVF/incubator, Group 2 IVF/INVO, Group 3 ICSI/INVO and Group 4 ICSI/incubator. The patients' weight, the number of ovocytes retrieved, mature ovules (M2), implantation rate, pregnancy and abortion rates were measured in each group. The Kruskal-Wallis test was used for statistical analysis; embryo quality was evaluated by multivariate covariance analysis (MANOVA). Results: A significant difference was observed regarding embryo quality between IVF and INVO (p = 0.0388), the INVO technique having higher embryo cleavage rates (μ = 7.35/INVO cf 6.64/ incubator) and lower embryo fragmentation (μ = 4.67/INVO cf 4.59/incubator). INVO groups also had higher percentages concerning their implantation, pregnancy and abortion rates. Conclusion: The INVO technique led to obtaining better quality embryos; implantation, pregnancy and abortion rates were similar to those described for the IVF technique. Source


Lucena E.,Centro Colombiano Of Fertilidad Y Esterilidad Cecolfes | Saa A.M.,Centro Colombiano Of Fertilidad Y Esterilidad Cecolfes | Navarro D.E.,Centro Colombiano Of Fertilidad Y Esterilidad Cecolfes | Pulido C.,Centro Colombiano Of Fertilidad Y Esterilidad Cecolfes | And 2 more authors.
The Scientific World Journal | Year: 2012

Intravaginal culture (IVC), also called INVO (intravaginal culture of oocytes), is an assisted reproduction procedure where oocyte fertilization and early embryo development are carried out within a gas permeable air-free plastic device, placed into the maternal vaginal cavity for incubation. In the present study we assessed the outcome of the INVO procedure, using the recently designed INVOcell device, in combination with a mild ovarian stimulation protocol. A total of 125 cycles were performed. On average 6.5 oocytes per cycle were retrieved, and a mean of 4.2 were placed per INVOcell device. The cleavage rate obtained after the INVO culture was 63. The procedure yielded 40, 31.2, and 24 of clinical pregnancy, live birth, and single live birth rates per cycle, respectively. Our results suggest that the INVO procedure is an effective alternative treatment option in assisted reproduction that shows comparable results to those reported for existing IVF techniques. Copyright © 2012 Elkin Lucena et al. Source

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