Central University of Punjab

Sonipat, India

Not to be confused with University of Central Punjab, Pakistan.The Central University of Punjab is a Central University located in Bathinda, Punjab, India. It has been established through an Act of Parliament: “The Central Universities Act, 2009" by Govt. of India. The territorial jurisdiction of Central University of Punjab is whole of the State of Punjab. Central University of Punjab has been ranked as number one amongst newly established central universities in India consistently since 2012 as per university rankings of Researchgate and Scopus.The Central Universities Bill 2009 aims at creating one new central university each in Bihar, Gujarat, Haryana, Himachal Pradesh, Jammu and Kashmir, Jharkhand, Karnataka, Kerala, Orissa, Punjab, Rajasthan and Tamil Nadu. It also seeks to convert Guru Ghasidas Vishwavidyalaya in Chhattisgarh, Harisingh Gour Vishwavidyalaya in Sagar and Hemwati Nandan Bahuguna Garhwal University in Uttarakhand into Central universities. Wikipedia.

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Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and aromatization of 5-(2-aminophenyl)-4,5-dihydro-3-arylpyrazole-1-carbaldehyde (7) under MeOH (route E) for the synthesis of a series of pyrazolo[1,5-c] quinazolines and their derivatives (1a-1q) are reported. © 2014 Elsevier Ltd. All rights reserved.

Bast F.,Central University of Punjab
Resonance | Year: 2014

Seaweeds are taxonomically diverse group of marine plants from which the land plants diverged over fifty crore years ago. Traditionally having been classified based on plant color as green, brown and red, modern molecular systematic evidences suggest that these plants are extraordinarily diverse. A number of seaweeds are edible and have been projected as a future food source. Seaweeds are also important to humanity in a number of ways, including as a source of medicines, food supplements, industrial chemicals, and as a potential candidate for biofuel research and CCS (carbon capture and sequestration). This article introduces the readers to the fascinating world of marine biology in general and seaweeds in particular, with an emphasis on Indian flora. © 2014 Indian Academy of Sciences.

Singh P.,Central University of Punjab | Alex J.M.,Central University of Punjab | Bast F.,Central University of Punjab
Medical Oncology | Year: 2014

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning numerous biological processes, has lately made its mark as a much sought-after therapeutic targets for diabetes and cancer. These receptors make an attractive anticancer target owing to their overexpression in variety of cancer especially in prostate and breast cancer. Inhibitors of IGF signaling were subjected to clinical cancer trials with the main objective to confirm the effectiveness of these receptors as a therapeutic target. However, the results that these trials produced proved to be disappointing as the role played by the cross talk between IGF and insulin receptor (IR) signaling pathways at the receptor level or at downstream signaling level became more lucid. Therapeutic strategy for IGF-1R and IR inhibition mainly encompasses three main approaches namely receptor blockade with monoclonal antibodies, tyrosine kinase inhibition (ATP antagonist and non-ATP antagonist), and ligand neutralization via monoclonal antibodies targeted to ligand or recombinant IGF-binding proteins. Other drug-discovery approaches are employed to target IGF-1R, and IR includes antisense oligonucleotides and recombinant IGF-binding proteins. However, therapies with monoclonal antibodies and tyrosine kinase inhibition targeting the IGF-1R are not evidenced to be satisfactory as expected. Factors that are duly held responsible for the unsuccessfulness of these therapies include (a) the existence of the IR isoform A overexpressed on a variety of cancers, enhancing the mitogenic signals to the nucleus leading to the endorsement of cell growth, (b) IGF-1R and IR that form hybrid receptors sensitive to the stimulation of all three IGF axis ligands, and (c) IGF-1R and IR that also have the potential to form hybrid receptors with other tyrosine kinase to potentiate the cellular transformation, tumorigenesis, and tumor vascularization. This mini review is a concerted effort to explore and fathom the well-recognized roles of the IRA signaling system in human cancer phenotype and the main strategies that have been so far evaluated to target the IR and IGF-1R. © 2013 Springer Science+Business Media New York.

Kumar S.,Central University of Punjab
Nonlinear Dynamics | Year: 2016

The Biswas-Milovic equation in generalized form and with power law nonlinearity is analyzed for Lie symmetries. The classical Lie group method is applied to derive symmetries of this equation, and the ordinary differential equations deduced are further studied; and some exact solutions are obtained. © 2016 Springer Science+Business Media Dordrecht

Chauhan M.,Central University of Punjab | Kumar R.,Central University of Punjab
Bioorganic and Medicinal Chemistry | Year: 2013

Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. The advent of their first bioactivity as adenosine antagonistic property divulged their medicinal potential. Radioactivity test on mice cells, morphometric and serological tests on rat hepatocytes, antitumor testing against L1210 and P388 leukemias in mice threw light on their biophysical aspects of significance. Biochemical properties were explored via xanthine oxidase assay, antioxidant enzyme assays, Western blot analysis, mRNA expression of apoptopic genes, receptor binding assays, and tryptan blue exclusion cytotoxicity evaluation. The collective results of biochemical and biophysical properties foregrounded their medicinal significance in central nervous system, cardiovascular system, cancer, inflammation etc. The present manuscript to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structure-activity relationships of pyrazolo[3,4-d]pyrimidines reported to date. © 2013 Elsevier Ltd. All rights reserved.

Mantha A.K.,Central University of Punjab | Mantha A.K.,University of Texas Medical Branch | Sarkar B.,Central University of Punjab | Tell G.,University of Udine
Mitochondrion | Year: 2014

Oxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), all of which are repaired by the base excision repair (BER) pathway, one among the six known repair pathways. BER-pathway in mammalian cells involves several evolutionarily conserved proteins and is also linked to genome replication and transcription. The BER-pathway enzymes, namely, DNA glycosylases (DGs) and the end-processing proteins such as abasic endonuclease (APE1), form complexes with downstream repair enzymes via protein-protein and DNA-protein interactions. An emerging concept for BER proteins is their involvement in non-canonical functions associated to RNA metabolism, which is opening new interesting perspectives. Various mechanisms that are underlined in maintaining neuronal cell genome integrity are identified, but are inconclusive in providing protection against oxidative damage in neurodegenerative disorders, main emphasis is given towards the role played by the proteins of BER-pathway that is discussed. In addition, mechanisms of action of BER-pathway in nuclear vs. mitochondria as well as the non-canonical functions are discussed in connection to human neurodegenerative diseases. © 2013 © Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Munshi A.,Central University of Punjab | Sharma V.,Osmania University
Current Pharmaceutical Design | Year: 2015

Stroke is the fourth leading cause of mortality and neurological disability. It is caused by an intricate interplay of environmental and genetic factors. Genes not only influence susceptibility to stroke but have also been found to alter the response to pharmacological agents and may also influence the clinical outcome of the disease. Current treatment strategies for stroke include tissue plasminogen activator, antiplatelet agents and lipid lowering drugs. These act via diverse mechanisms of actions and are centered around the management of modifiable risk factors to prevent the recurrent stroke events. However, a significant number of patients experience poor clinical outcome due to recurrent stroke events and drug induced adverse reactions. Therefore, accurate risk management and targeted prevention strategies remain yet to be explored at the level of individual patients with stroke. Pharmacogenetic based research studies have identified the relation between genetic factors and inter-individual variability towards drug treatment. Several single nucleotide polymorphisms in genes encoding for metabolizers, transporters and target receptors have been reported to influence the pharmacokinetics and pharmacodynamics of drugs used in the treatment of stroke. Many candidate gene studies have investigated the role of genetic variants in association with altered drug response in stroke treatment. However, these results are limited to clinical trials and should be replicated in Genome Wide Association (GWAS) Studies. In addition to this long term follow up prospective studies would be helpful in predicting drug induced risk/benefit ratio. Pharmacogenetic studies will reveal the correlation between variation in drug responses on the basis of the individual’s genomic profile better known as Personalized or Individualized Medicines. This will also optimize risk assessment and will stratify the population requiring careful attention before prescribing a particular medicine to achieve maximum therapeutic benefit. Moreover, this will help in designing the novel therapeutic agents with a targeted approach. In this concern, the Genomics and Randomized Trials Network (GARNET) has been created, which is a Pharmacogenomics Consortium aimed to identify genetic variants affecting an individual's response to treatment with the help of advanced technology. This review will address the major issues of therapeutic failures concerned with existing drugs used in the treatment of stroke and the need for exploring new and targeted therapeutic strategies based on pharmacogenetics. © 2015 Bentham Science Publishers.

Alex J.M.,Central University of Punjab | Kumar R.,Central University of Punjab
Journal of Enzyme Inhibition and Medicinal Chemistry | Year: 2014

Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles became an inevitable core of numerous drugs having diverse activities. The broad spectrum of activities portrayed by the pyrazoles instigated the researchers to modify the pyrazole ring as 4,5-dihydro-1H-pyrazoles commonly known as 2-pyrazolines. The present review is a concerted effort to retrace compounds covered from 2009-till date which owe diverse biological activities to the 2-pyrazoline scaffold and also condenses the retro-synthetic approaches employed for their synthesis. This endeavor culminated in revelation that inhibitory potential varied when the substituents in particular N-substituents of 2-pyrazolines were altered. © 2014 Informa UK Ltd.

Bhalla Y.,Central University of Punjab | Gupta V.K.,Central University of Punjab | Jaitak V.,Central University of Punjab
Journal of the Science of Food and Agriculture | Year: 2013

Natural essential oil constituents play an important role in cancer prevention and treatment. Essential oil constituents from aromatic herbs and dietary plants include monoterpenes, sesquiterpenes, oxygenated monoterpenes, oxygenated sesquiterpenes and phenolics among others. Various mechanisms such antioxidant, antimutagenic and antiproliferative, enhancement of immune function and surveillance, enzyme induction and enhancing detoxification, modulation of multidrug resistance and synergistic mechanism of volatile constituents are responsible for their chemopreventive properties. This review covers the most recent literature to summarize structural categories and molecular anticancer mechanisms of constituents from aromatic herbs and dietary plants. © 2013 Society of Chemical Industry.

Kumar S.,Central University of Punjab
Nonlinear Dynamics | Year: 2016

The Vakhnenko–Parkes (VP) equation with power law nonlinearity is analyzed for Painlevé test and for Lie symmetries. The Painlevé analysis of Vakhnenko–Parkes equation with power law nonlinearity is performed by the Kruskal approach to check the Painlevé property. The Lie group formalism is also applied to derive symmetries of this equation, the ordinary differential equations deduced are further studied, and some exact solutions are obtained. © 2016 Springer Science+Business Media Dordrecht

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