Vallabh Vidyanagar, India

Central University of Kerala
Vallabh Vidyanagar, India

Central University of Kerala is one of the 15 new Central Universities established under The Central Universities Act, 2009 . CUK aims to extend the scope of learning through a holistic methodology that accommodates diverse linguistic, scientific and cultural traditions. CUK is situated at Kasaragod, the northern-most district of Kerala, and has state-wide jurisdiction. It started functioning from a transit campus in Vidyanagar housing the Administrative Offices, Humanities Schools, University Library, Computer Centre, Language Lab, and the University Guest House. The Riverside Transit Campus at Padannakad, 35 km further south, houses the Science Schools. The permanent campus of the university is being set up at Periye on a panoramic stretch of 310 acres of land beside the National Highway, at which academic activity will commence from the ensuing academic year. Wikipedia.

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Ghosh K.,Central University of Kerala | Yadav N.,Central University of Kerala | Kanade S.R.,Central University of Kerala
Journal of Biochemistry | Year: 2017

Lectins are omnipresent in almost all life forms, being the proteins which specifically bind to carbohydrate moieties on the cell surface; they have been explored for their anti-tumour activities. In this study, we purified a fucose specific-lectin (IFL) from Fenneropenaeus indicus haemolymph using fucose-affinity column and characterized for its haemagglutination activity, carbohydrate specificity, dependency on cations and cytotoxicity against cancer cells. The lectin showed nonspecificity against human erythrocytes. It was a Ca2+-dependent lectin which remained stable over wide pH and temperature ranges. The lectin showed effective dose dependent cytotoxicity against different human cancer cell lines and induced apoptosis in MCF- 7 cells as evidenced by DNA ladder assay and PARP cleavage in a dose dependent manner. Moreover, an increased p21 level corresponding to cyclin D downregulation in response to IFL treatment was observed which might work as probable factors to inhibit cell growth and induce apoptosis of MCF-7 cells. Therefore, we report a novel lectin from the prawn haemolymph with high specificity for L-fucose and antiproliferative towards human cancer cells. However, further establishment of the modus operandi of this lectin is required to enable its biotechnological applications. © The Authors 2016. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

Sivanandam T.M.,Banaras Hindu University | Sivanandam T.M.,Central University of Kerala | Thakur M.K.,Banaras Hindu University
Neuroscience and Biobehavioral Reviews | Year: 2012

Traumatic brain injury (TBI) constitutes a major global health and socio-economic problem with neurobehavioral sequelae contributing to long-term disability. It causes brain swelling, axonal injury and hypoxia, disrupts blood brain barrier function and increases inflammatory responses, oxidative stress, neurodegeneration and leads to cognitive impairment. Epidemiological studies show that 30% of patients, who die of TBI, have Aβ plaques which are pathological features of Alzheimer's disease (AD). Thus TBI acts as an important epigenetic risk factor for AD. This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions. © 2012 Elsevier Ltd.

Vilfred V.,Central University of Kerala
2017 7th International Conference on Modeling, Simulation, and Applied Optimization, ICMSAO 2017 | Year: 2017

We present different properties of circulant graphs that includes (i) On the existence of self-complementary circulant graphs; (ii) Type-2 isomorphism, a new type of isomorphism other than already known Adam's isomorphism of circulant graphs and new abelian groups; (iii) Cartesian product and factorization of circulant graphs similar to the theory of product and factorization of natural numbers. © 2017 IEEE.

Roshnath R.,Central University of Kerala
Journal of Threatened Taxa | Year: 2017

Sightings of Grey-headed Lapwings wintering in Kerala were compiled from different sources. With a total of 77 sightings from 1999-2016 in Kerala the bird, which was earlier thought to be a rare winter visitor, was found to be a frequent visitor to the state. Kole wetland, Vellayani-Punchakkari paddy fields and Kattampally wetlands were the sites in Kerala with fairly regular sightings of the bird. From the records, it was found that they are here from October to April, with a maximum number of sightings in January. © Roshnath 2017.

Ghufran M.S.,Central University of Kerala | Ghosh K.,Central University of Kerala | Kanade S.R.,Central University of Kerala
Toxicon | Year: 2016

The exposure of naturally occurring mycotoxins affects human health and play a vital role in cancer initiation and progression. Aflatoxin B1 is a difuranocoumarin mycotoxin, classified as a group I carcinogen. The present study was conducted to assess the effect of aflatoxin B1 on epigenetic regulatory proteins. The protein arginine methyltransferase 5 expression was induced upon aflatoxin B1 treatment in a dose and time dependent manner. Further global arginine methylation was also increased in the same manner. This is the first report showing the induction of epigenetic regulatory protein, protein arginine methyltransferase 5 upon aflatoxin B1 treatment. Further study is required to establish the detailed pathway of PRMT5 induction. © 2016 Elsevier Ltd. All rights reserved.

Ullattil S.G.,University of CalicutKerala | Periyat P.,University of CalicutKerala | Periyat P.,Central University of Kerala
Journal of Materials Chemistry A | Year: 2016

A one pot gel combustion synthetic strategy has been developed for the first time towards the rapid formation of self-doped black anatase TiO2-x (BAT) using titanium butoxide, diethylene glycol (DEG) and water as the only precursors. This swiftly formed nanoplatform was occupied with a high concentration of surface defect sites, especially Ti3+ and oxygen vacancy sites in excess. The in (lattice) and out (surface) defect states were confirmed by Raman, XPS and TEM analysis. These defect-enriched features enabled 33% more photocatalytic activity for BAT than the commercially available photocatalyst Degussa-P25 under solar illumination. © The Royal Society of Chemistry 2016.

Inesi G.,California Pacific Medical Center Research Institute | Pilankatta R.,Central University of Kerala | Tadini-Buoninsegni F.,University of Florence
Biochemical Journal | Year: 2014

Copper ATPases, in analogy with other members of the P-ATPase superfamily, contain a catalytic headpiece including an aspartate residue reactingwithATP to form a phosphoenzyme intermediate, and transmembrane helices containing cation-binding sites [TMBS (transmembrane metal-binding sites)] for catalytic activation and cation translocation. Following phosphoenzyme formation by utilization of ATP, bound copper undergoes displacement from the TMBS to the lumenal membrane surface, with no H+ exchange. Although PII-type ATPases sustain active transport of alkali/alkali-earth ions (i.e. Na+, Ca2+) against electrochemical gradients across defined membranes, PIB-type ATPases transfer transition metal ions (i.e. Cu+) from delivery to acceptor proteins and, prominently in mammalian cells, undergo trafficking from/to various membrane compartments. A specific component of copper ATPases is the NMBD (N-terminal metalbinding domain), containing up to six copper-binding sites in mammalian (ATP7A and ATP7B) enzymes. Copper occupancy of NMBD sites and interaction with the ATPase headpiece are required for catalytic activation. Furthermore, in the presence of copper, the NMBD allows interaction with protein kinase D, yielding phosphorylation of serine residues, ATP7B trafficking and protection from proteasome degradation. A specific feature of ATP7A is glycosylation and stabilization on plasma membranes. Cisplatin, a platinum-containing anti-cancer drug, binds to copper sites ofATP7A andATP7B, and undergoes vectorial displacement in analogy with copper. © 2014 Biochemical Society.

Mandal D.,Hebrew University of Jerusalem | Ramanan R.,Hebrew University of Jerusalem | Usharani D.,Hebrew University of Jerusalem | Usharani D.,Indian Central Food Technological Research Institute | And 4 more authors.
Journal of the American Chemical Society | Year: 2015

This article addresses the intriguing hydrogen-abstraction (H-abstraction) and oxygen-transfer (O-transfer) reactivity of a series of nonheme [FeIV(O)(TMC)(Lax)]z+ complexes, with a tetramethyl cyclam ligand and a variable axial ligand (Lax), toward three substrates: 1,4-cyclohexadiene, 9,10-dihydroanthracene, and triphenyl phosphine. Experimentally, O-transfer-reactivity follows the relative electrophilicity of the complexes, whereas the corresponding H-abstraction-reactivity generally increases as the axial ligand becomes a better electron donor, hence exhibiting an antielectrophilic trend. Our theoretical results show that the antielectrophilic trend in H-abstraction is affected by tunneling contributions. Room-temperature tunneling increases with increase of the electron donation power of the axial-ligand, and this reverses the natural electrophilic trend, as revealed through calculations without tunneling, and leads to the observed antielectrophilic trend. By contrast, O-transfer-reactivity, not being subject to tunneling, retains an electrophilic-dependent reactivity trend, as revealed experimentally and computationally. Tunneling-corrected kinetic-isotope effect (KIE) calculations matched the experimental KIE values only if all of the H-abstraction reactions proceeded on the quintet state (S = 2) surface. As such, the present results corroborate the initially predicted two-state reactivity (TSR) scenario for these reactions. The increase of tunneling with the electron-releasing power of the axial ligand, and the reversal of the "natural" reactivity pattern, support the "tunneling control" hypothesis (Schreiner et al., ref 19). Should these predictions be corroborated, the entire field of C-H bond activation in bioinorganic chemistry would lay open to reinvestigation. © 2014 American Chemical Society.

R A.,Thomas College | Mathew V.,Central University of Kerala
Plasmonics | Year: 2013

We study the properties of surface plasmon polaritons at an interface between a metal and a strongly nonlinear magnetic cladding, characterized by permeability μ = μ1 + μn1H2. It is observed that the dispersion of modes has a significant dependance on the incident power. The incident power can be adjusted to control the propagation length. In addition, the structure shows strong confinement of the modes at the interface. © 2012 Springer Science+Business Media, LLC.

D'Souza N.M.,Central University of Kerala | Mathew V.,Central University of Kerala
Applied Optics | Year: 2015

The microwave optical properties of a photonic crystal-based tunable single and multichannel filter are theoretically investigated using the transfer matrix method, finite difference time domain method, and the plane wave expansion method. By applying an external voltage of 8 V/micron about a 35% frequency tuning is obtained. It is found that the number of transmission peaks is directly proportional to the number of periods (N). In addition to this, the dependence of layer thicknesses, angle of incidence and polarization are also analyzed, and it is noticed that the filtering frequency is invariant in angle and polarization. © 2015 Optical Society of America.

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