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Granitov V.,Altai State Medical University | Shpynov S.,N.F. Gamaleya FRCEM | Beshlebova O.,Altai State Medical University | Arsenjeva I.,Altai State Medical University | And 5 more authors.
Microbes and Infection | Year: 2015

Tick-borne rickettsioses (TBRs) have similar clinical symptoms and can give serological cross-reaction. We firstly found that in the natural foci of North Asian tick typhus (NATT) in the Altai region of Russia, TBRs can be caused by two Rickettsia species: Rickettsia sibirica subsp. sibirica (causative agent of NATT) and Rickettsia heilongjiangensis. Rickettsial DNA was detected in primary lesions, serum samples and blood clots using real-time PCR. Therefore, each case of TBRs should be verified by using molecular typing. TBR caused by R. sibirica subsp. sibirica - NATT dominates on the territory of Altai region. © 2015 Institut Pasteur. Source


Zhogina Y.A.,Central Research Institute for Epidemiology CRIE | Glazkova D.V.,Central Research Institute for Epidemiology CRIE | Vetchinova A.S.,Central Research Institute for Epidemiology CRIE | Bogoslovskaya E.V.,Central Research Institute for Epidemiology CRIE | And 2 more authors.
Russian Journal of Biopharmaceuticals | Year: 2014

A promising approach in the treatment of HIV infection is a gene therapy based on the integration of antiviral genes into the genome of the host cell. We have constructed three antiviral genes, which were described previously — TAR decoy, ENV antisense and a modified gene TRIM5α. Antiviral activities of those genes have been compared using immortalized lymphoid cell line MT4. It was shown that the modified gene TRIM5a possesses the highest level of anti-HIV-1 activity. © 2014 Folium Ltd. All rights reserved. Source

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