Central Research Institute for Epidemiology CRIE

Moscow, Russia

Central Research Institute for Epidemiology CRIE

Moscow, Russia
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Dedkov V.G.,Central Research Institute for Epidemiology CRIE | Dedkov V.G.,Research Institute of Occupational Health | Simonova E.G.,Central Research Institute for Epidemiology CRIE | Simonova E.G.,Im Sechenov First Moscow Medical University | And 10 more authors.
Ticks and Tick-borne Diseases | Year: 2017

This article presents the results of a comprehensive survey of the burden of tick-borne infectious diseases (TBIDs) in the Altai region of Russia. Official data for TBID incidence were analyzed and 201 samples from patients with suspected TBID were studied. Furthermore, questing ticks and ticks recovered from humans were examined to estimate prevalence of TBID-causative agents. The Altai region was determined to have a heightened risk for TBIDs in Russia. The most epidemiologically significant tick-borne illness in this area is spotted fever group rickettsiosis, while nationally in Russia, the leading TBID is Lyme borreliosis. The prevalence of mixed infection was 12.4% among the studied cases. Additionally, the prevalence of poorly studied pathogens - Kemerovo virus (KEMV) and Rickettsia tarasevichiae - in ticks from the Altai region was determined. © 2017 Elsevier GmbH.


Zhogina Y.A.,Central Research Institute for Epidemiology CRIE | Glazkova D.V.,Central Research Institute for Epidemiology CRIE | Vetchinova A.S.,Central Research Institute for Epidemiology CRIE | Bogoslovskaya E.V.,Central Research Institute for Epidemiology CRIE | And 2 more authors.
Russian Journal of Biopharmaceuticals | Year: 2014

A promising approach in the treatment of HIV infection is a gene therapy based on the integration of antiviral genes into the genome of the host cell. We have constructed three antiviral genes, which were described previously — TAR decoy, ENV antisense and a modified gene TRIM5α. Antiviral activities of those genes have been compared using immortalized lymphoid cell line MT4. It was shown that the modified gene TRIM5a possesses the highest level of anti-HIV-1 activity. © 2014 Folium Ltd. All rights reserved.


Granitov V.,Altai State Medical University | Shpynov S.,N.F. Gamaleya FRCEM | Beshlebova O.,Altai State Medical University | Arsenjeva I.,Altai State Medical University | And 5 more authors.
Microbes and Infection | Year: 2015

Tick-borne rickettsioses (TBRs) have similar clinical symptoms and can give serological cross-reaction. We firstly found that in the natural foci of North Asian tick typhus (NATT) in the Altai region of Russia, TBRs can be caused by two Rickettsia species: Rickettsia sibirica subsp. sibirica (causative agent of NATT) and Rickettsia heilongjiangensis. Rickettsial DNA was detected in primary lesions, serum samples and blood clots using real-time PCR. Therefore, each case of TBRs should be verified by using molecular typing. TBR caused by R. sibirica subsp. sibirica - NATT dominates on the territory of Altai region. © 2015 Institut Pasteur.


PubMed | Central Research Institute for Epidemiology CRIE, <<N.F. Gamaleya FRCEM>> and Altai State Medical University
Type: Journal Article | Journal: Microbes and infection | Year: 2015

Tick-borne rickettsioses (TBRs) have similar clinical symptoms and can give serological cross-reaction. We firstly found that in the natural foci of North Asian tick typhus (NATT) in the Altai region of Russia, TBRs can be caused by two Rickettsia species: Rickettsia sibirica subsp. sibirica (causative agent of NATT) and Rickettsia heilongjiangensis. Rickettsial DNA was detected in primary lesions, serum samples and blood clots using real-time PCR. Therefore, each case of TBRs should be verified by using molecular typing. TBR caused by R. sibirica subsp. sibirica - NATT dominates on the territory of Altai region.

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