Central Research Institute Ayurveda

Bidhannagar, India

Central Research Institute Ayurveda

Bidhannagar, India

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Bhattacharyya A.,Lane College | Bhaumik A.,Indian Association for The Cultivation of Science | Rani P.U.,Indian Institute of Chemical Technology | Mandal S.,Central Research Institute Ayurveda | Epidi T.T.,Niger Delta University
African Journal of Biotechnology | Year: 2010

Nanotechnology, a promising field of research opens up in the present decade a wide array of opportunities in the present decade and is expected to give major impulses to technical innovations in a variety of industrial sectors in the future. The potential uses and benefits of nanotechnology are enormous. These include agricultural productivity enhancement involving nanoporous zeolites for slow release and efficient dosage of water and fertilizer, nanocapsules for herbicide delivery and vector and pest management and nanosensors for pest detection. The atom by atom arrangement allows the manipulation of nanoparticles thus influencing their size, shape and orientation for reaction with the targeted tissues. It is now known that many insects possess ferromagnetic materials in the head, thorax and abdomen, which act as geomagnetic sensors. In this paper, our discussion is focused on nanoparticles in insects and their potential for use in insect pest management. © 2010 Academic Journals.


Kartika R.,National Botanical Research Institute | Raoa C.V.,National Botanical Research Institute | Pushpangadanb P.,Amity Institute for Herbal and Biotech Products Development | Trivedic S.P.,University of Lucknow | Reddyd G.D.,Central Research Institute Ayurveda
Iranian Journal of Pharmaceutical Sciences | Year: 2010

This study was designed to explore the protective effects of Abrus precatorius L. (Leguminosae) (AP) in HepG2 cells and N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in Swiss albino rats. The effects of aqueous/ethanolic (50%) extract of AP on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in NDEA (200 mg/kg and CCl4, 3 ml/kg body weight) induced experimental hepatocarcinogenesis in Swiss albino rats. In addition, cytotoxicity of the extract and its effect on the expression on p53 were studied in human hepatoma cell line (HepG2). Results obtained from cytotoxicity studies showed that the AP extract has strong cytotoxic effects on HepG2 cells. The expression of p53 was markedly increased and maintained at high level from 6-12 hr with 100 μg/ml of AP extract. A decrease in the mean and relative liver weights in AP extract treated group at a dose of 100 and 200 mg/kg was observed compared to the control group. It was also demonstrated that AP extract provided significant protection against hepatic lipid peroxidation and increased antioxidant enzymes' activities such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and reduced glutathione levels. In a dose-dependent manner, the AP extract reduced the NDEA-induced elevated levels of various hepatic markers such as serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, total bilirubin and gamma glutamate transpeptidase. The haematological paremater viz. RBC, WBC and haemaglobin was restored upon treatment with AP extract at 100 and 200 mg/kg. Histopathology of the liver was also carried out to mark the pathological changes in groups under study. The results of these studies demonstrate the protective effect of AP extract against NDEA induced hepatocarcinogenesis in Swiss albino rats and in HepG2 cell.


Kartik R.,Translational Cancer Research Laboratory | Kartik R.,National Botanical Research Institute | Rao C.V.,Translational Cancer Research Laboratory | Rao C.V.,National Botanical Research Institute | And 3 more authors.
Indian Journal of Pharmacology | Year: 2010

Objective: The prevalence of oxidative stress may be implicated in the etiology of many pathological conditions. Protective antioxidant action imparted by many plant extracts and plant products make them a promising therapeutic drug for free-radical-induced pathologies. In this study, we assessed the antioxidant potential and suppressive effects of Achyranthes aspera by evaluating the hepatic diagnostic markers on chemical-induced hepatocarcinogenesis. Materials and Methods: The in vivo model of hepatocarcinogenesis was studied in Swiss albino rats. Experimental rats were divided into five groups: control, positive control (NDEA and CCl 4 ), A. aspera treated (100, 200, and 400 mg/kg b.w.). At 20 weeks after the administration of NDEA and CCl 4 , treated rats received A. aspera extract (AAE) at a dose of 100, 200, and 400 mg/kg once daily route. At the end of 24 weeks, the liver and relative liver weight and body weight were estimated. Lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and reduced glutathione (GSH) were assayed. The hepatic diagnostic markers namely serum glutamic oxaloacetic transminase (AST), serum glutamic pyruvate transminase (ALT), serum alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), and bilirubin (BL) were also assayed, and the histopathological studies were investigated in control, positive control, and experimental groups. Results: The extract did not show acute toxicity and the per se effect of the extract showed decrease in LPO, demonstrating antioxidant potential and furthermore no change in the hepatic diagnosis markers was observed. Administration of AAE suppressed hepatic diagnostic and oxidative stress markers as revealed by decrease in NDEA and CCl 4 -induced elevated levels of SGPT, SGOT, SALP, GGT, bilirubin, and LPO. There was also a significant elevation in the levels of SOD, CAT, GPx, GST, and GSH as observed after AAE treatment. The liver and relative liver weight were decreased after treatment with AAE in comparison to positive control group. The architecture of hepatic tissue was normalized upon treatment with extract at different dose graded at 100, 200, and 400 mg/kg. b.w. in comparison to positive control group. Conclusion: These results suggest that A. aspera significantly alleviate hepatic diagnostic and oxidative stress markers which signify its protective effect against NDEA and CCl 4 -induced two-stage hepatocarcinogenesis.


De D.,Vidyasagar University | Chatterjee K.,Vidyasagar University | Ali K.M.,Vidyasagar University | Mandal S.,Central Research Institute Ayurveda | And 2 more authors.
Journal of Applied Biomedicine | Year: 2010

Natural products with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. This present work focuses on the antidiabetic activity of a hydro-methanolic (2:3) extract of the sepals of Salmalia malabarica on the blood glucose, the carbohydrade metabolic enzyme, oxidative stress, glycated haemoglobin and transaminase activity in streptozotocin (STZ) induced diabetic rats. Diabetic rats show a significant diminution in the activities of hexokinase, glucose-6-phosphate dehydrogenase and an elevation in the activity of glucose-6-phosphatase in the liver and skeletal muscle. Administration of hydro-methanolic extract of the sepals of Salmalia malabarica to diabetic rats resulted in a significant recovery in the parameters concerned. In the liver and kidney, the activities of catalase (CAT) and peroxidase (Px) were decreased significantly and levels of conjugated diene (CD) and thio-barbituric acid reactive substance (TBARS) were increased significantly in diabetic rats which recovered significantly after administration of hydro-methanolic extract of S. malabarica. Serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) activities which are increased in diabetes were restored by the extract. Glycated haemoglobin (HbA1C) levels were resettled significantly in the extract treated group compared to the diabetic group. The antidiabetic activity of the extract was supported after a comparison with glibenclamide, a standard antidiabetic drug.


PubMed | Central Research Institute Ayurveda
Type: Journal Article | Journal: Ancient science of life | Year: 2012

A Clinical trial of Indigenous compound drug Nishamalaki was carried out in the CRI (Ayurveda) Hospital, Jaipur on the patient of Madhumeha. For this study, patients were randomly divided into two groups of 25 individuals each and they were termed as group A and B. The individuals of group a were administered Nishamalaki in a dose of one gram twice daily along with diet control, the patients were followed every fort nightly. A significant improvement in the symptoms along with lowering of blood glucose level was observed in the individuals of group B, while the individuals of group A responded initially but could not sustain the same.


PubMed | Central Research Institute Ayurveda
Type: Journal Article | Journal: Ancient science of life | Year: 2012

In this paper an attempt has been made to evaluate the theory of Ayurveda on rheumatoid arthritis, in relation to the modern medical concept. The evolution of the disease, its etiopathogenesis, its pathological, biochemical as well as therapeutic data published in support of this concept and finally the details of clinical trial of Sunthi in treating 265 patients are dealt with.


De D.,Vidyasagar University | Bera T.K.,Vidyasagar University | Ali K.M.,Vidyasagar University | Mandal S.,Central Research Institute Ayurveda | And 2 more authors.
Biomarkers and Genomic Medicine | Year: 2013

The antidiabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition in carbohydrate-digesting enzymes such as α-amylase and α-glucosidase. The present study was designed to investigate the α-amylase and α-glucosidase inhibition in the n-hexane fraction of sepal of Salmalia malabarica. The fraction showed concentration-dependent α-amylase (IC50=50.17mg/L) and α-glucosidase (IC50=61.04mg/L) inhibitory activity. The positive invitro enzyme inhibition tests results were confirmed with an oral starch tolerance test with 18 hour fasted normoglycemic rats. Phytochemical study of the said plant part fraction revealed that is rich in total phenolic contents, flavonoids, and flavonol, which may be responsible for its pharmacological activity. In an acute toxicity study, the n-hexane fraction up to the dose level of 3000mg/kg body weight did not exhibit any lethality or toxic symptoms. From these results, it may be concluded that the n-hexane fraction may have an inhibitory effect on intestinal α-amylase and α-glucosidase activity, and can be used effectively as a safer alternative therapy to control postprandial hyperglycemia. © 2013.

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