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Ilhan-Mutlu A.,Medical University of Vienna | Ilhan-Mutlu A.,Central Nervous System Tumours Unit | Wagner L.,Medical University of Vienna | Wagner L.,Central Nervous System Tumours Unit | And 9 more authors.
Cancer Investigation | Year: 2012

Background: There is little knowledge on blood alterations of glioblastoma. We had the opportunity to investigate markers from plasma taken 66, 36, and 6 months before glioblastoma in a patient in the VITA study. Methods: We determined S100B, secretagogin, neuropeptide-Y, micro-RNA-21, let-7, micro-RNA-128, and micro-RNA-3423p in our patient and 10 controls from VITA. Results: We found a four-fold increase of micro-RNA-21 in the plasma of glioblastoma patient, whereas controls showed a significant decrease. There was no difference in other protein or micro-RNA levels between the patient and controls. Conclusion: Plasma micro-RNA-21 may be associated with glioblastoma development in individual cases. © 2012 Informa Healthcare USA, Inc.

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