Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar

Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar


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Kishore N.,Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar | Raja M.D.,Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar | Dhanalekshmi U.,Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar | Srinivasan R.,Central Leather Research InstituteCouncil of Scientific and Industrial Research CSIR Adyar
European Journal of Lipid Science and Technology | Year: 2015

Celecoxib loaded tristearin lipid nanoparticles (CEL-TS-LN) formulation was prepared by micro emulsion technique. The prepared CEL-TS-LN formulations were characterized by photon correlation spectroscopy (PCS), Zeta potential, transmission electron microscopy (TEM), in vitro release kinetics, In vivo toxicity and pharmacokinetics; and Freund's adjuvant-induced arthritic studies were conducted. The mean diameter of the CEL-TS-LN was about 188nm; the particles had spherical morphology and an amorphous nature. In vitro drug release study of CEL-TS-LN revealed sustained drug release of 62% for 36hrs; and the drug release was found to follow zero order and Fickian diffusion mechanism. The biochemical and haematology reports of in vivo toxicity studies revealed that CEL-TS-LN does not exhibit any toxic symptoms on vital organs and could be safe. With 88% percent inhibition of edema, serum biochemical parameters of CEL-TS-LN treated animal groups showed significant difference (p<0.05) compared to arthritic control (without treatment). In conclusion, the results clearly suggested that CEL-TS-LN facilitated sustained release enhanced bioavailability and improved therapeutic efficiency of the encapsulated celecoxib drug. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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