Tongshan, China
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Qi L.,Harvard University | Qi L.,Brigham and Women's Hospital | Liang J.,Central Hospital of Xuzhou
Current Opinion in Lipidology | Year: 2010

Purpose of review: The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D). Recent findings: Several studies reported that dietary factors related to carbohydrate quality and quantity, such as whole grains and glycemic load, might interact with transcription factor 7-like 2 variants in relation to T2D risk. The genetic predisposition defined by the combination of 10 established T2D risk alleles was found to modulate the association between Western dietary pattern (high intakes of red meat, processed meat, and low fiber) and T2D; a stronger association was observed in those with a high-risk genetic profile. Variants in genes HHEX, CDKN2A/2B, JAZF1, and IGF2BP2 were found to interact with prenatal nutrition in relation to T2D risk and glucose levels in later life. Summary: The available data provide preliminary support for the gene-diet interactions in determining T2D. However, most findings have yet to be validated. Future studies will need agreed standards of study design and statistical power, dietary measurement, analytical methods, and replication strategies. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Zhang X.,Harvard University | Zhang X.,Huazhong University of Science and Technology | Qi Q.,Harvard University | Liang J.,Harvard University | And 4 more authors.
Hypertension | Year: 2012

Neuropeptide Y (NPY) is implicated in the regulation of blood pressure (BP), and NPY pathways in the hypothalamus are sensitive to dietary fat. We evaluated the potential effect of a functional variant rs16147 located in the NPY gene promoter region on the association between 2-year diet intervention and change in multiple BP measures in the randomized Preventing Overweight Using Novel Dietary Strategies Trial. The NPY rs16147 was genotyped in 723 obese adults who were randomly assigned to 1 of 4 diets differing in the target percentages of energy derived from fat, protein, and carbohydrate. The changes of 4 BP phenotypes, including systolic BP, diastolic BP, pulse pressure, and mean arterial pressure, during 2-year diet intervention were analyzed. In the total participants and participants with hypertension, we observed significant and consistent interactions between rs16147 genotype and dietary fat intake on changes in multiple BP phenotypes at 2 years (all P for interactions <0.05). The risk allele (C allele) was associated with a greater reduction of BP phenotypes in response to low-fat diet, whereas an opposite genetic effect was observed in response to high-fat diet. In addition, the C allele was related to greater changes in 4 BP phenotypes in hypertensive compared with nonhypertensive participants. Our data suggest that NPY rs16147 may modulate the association between dietary fat intake and changes in BP phenotypes, and the C allele exerts a long-term beneficial effect on lowering BP in response to low-fat diet in obese and hypertensive subjects. © 2012 American Heart Association, Inc.


Qu D.-W.,Xuzhou Medical College | Xu H.-S.,Central Hospital of Xuzhou | Han X.-J.,Xuzhou Medical College | Wang Y.-L.,Xuzhou Medical College | Ouyang C.-J.,Xuzhou Medical College
European Review for Medical and Pharmacological Sciences | Year: 2014

OBJECTIVES: To investigate the expression of cyclinD1 and Ki-67 proteins in gliomas and its significance. PATIENTS AND METHODS: The immunohistochemistry was used to detect the expression of cyclinD1 and Ki-67 proteins in 18 cases of normal brain tissues, 32 cases of low-grade gliomas, and 24 cases of high-grade gliomas. RESULTS: The cyclinD1 positive ratio in normal brain tissues, low-grade gliomas, and high-grade gliomas were 4/18, 15/32, and 18/24, respectively, with statistically significant difference (p < 0.05). Differences were significant by pairwise comparison between normal brain tissue with high-grade gliomas and low-grade gliomas with high-grade glioma groups (p < 0.01). However, there was no significant differences between normal brain tissue with low-grade gliomas.The Ki-67 positive ratio in normal brain tissues, low-grade gliomas, and high-grade gliomas were 5/18, 21/32, and 20/24, respectively. The difference among three tissues was statistically significant (p < 0.05). Differences were significant by pairwise comparison between normal brain tissue with low-grade gliomas and normal brain tissue with high-grade glioma group (p < 0.01).There is no difference between low-grade gliomas and high-grade gliomas (p > 0.05). Spearman's rank correlation confirmed that cyclinD1 and Ki-67 was positively correlated in low-grade gliomas and high-level brain tumor (p < 0.05), but no correlation in the normal brain tissue (p > 0.05). CONCLUSIONS: The expression of CyclinD1 and Ki-67 increased in gliomas, suggesting that both may play an important role in the occurrence of gliomas.


Zhao H.,Central Hospital of Xuzhou
Chinese Journal of Cerebrovascular Diseases | Year: 2010

Objective: To investigate the role of the protein kinase C (PKC) inhibitor isoquinoline sulfonamides (H-7) on the brain damage following thrombin-induced cerebral hemorrhage in rats. Methods: A total of 54 healthy male SD rats were randomly allocated into 3 groups: control, thrombin, and H-7 intervention groups (n = 18 in each group). Thrombin (10 U, dissolved in 50 μL isotonic saline) was injected into the right caudate nucleus to establish the rat model. Immediately after the modeling procedure and at 24 hours, H-7 (1 mg/kg) was injected intraperitoneally in the H-7 intervention group; equal amount of isotonic saline was injected intraperitoneally in the control group. Hematoxylin and Eosin (HE) staining was used to observe the histopathological changes and inflammatory cell infiltration 48 hours after the modeling, the dye Evans blue assay was used to detect the blood-brain barrier (BBB) permeability, the dry-wet method was used to measure the brain water content, and TUNEL was used to observe the apoptosis in the injuried brain region. Results: Circled digit one Pathological observation showed that H-7 significantly improved brain injury induced by thrombin. Circled digit two The inflammatory cell counts around the right caudate nucleus in the control, thrombin, and H-7 intervention groups were 0.8 ± 0.7, 16.5 ± 1.0, and 10.0 ± 1.4, respectively. The apoptosis cell counts were 73 ± 5, 150 ± 12, and 118 ± 9. The brain water contents were 77.5 ± 1.1, 83.2 ± 0.4, and 78.8 ± 0.9%. The EB contents were 6.7 ± 0.5, 28.4 ± 3.2, and 16.0 ± 1.3 μg/g. When thrombin group compared with the control and H-7 intervention groups, there were significant differences among the above indices (P < 0.05 or P < 0.01). Conclusion: H-7 significantly reduces the brain injury following thrombin-induced cerebral hemorrhage. It may play a neuroprotective role by inhibiting the activation of PKC.


PubMed | Central Hospital of Xuzhou and Xuzhou Medical College
Type: Journal Article | Journal: Cell biochemistry and biophysics | Year: 2016

To study the inhibitory effect of Hedyotis diffusa on cervical cancer and its underlining biomolecular mechanism. Human cervical carcinoma nude mice xenograft was established and the mice were treated by intra-gastric administration of boiled and concentrated Hedyotis diffusa. When the tumor grew to 10mm in diameter, the mice were randomly divided into Hedyotis diffusa Willd. (HDW) group and control group. The tumor inhibitory rate, survival time, and the expression rate of Ki-67 protein in Hela cells as well as tumor cell apoptosis were compared between these two groups. Hedyotis diffusa had inhibitory effect on cervical cancer cells and induced apoptosis of Hela cells. The expression of Ki-67 protein significantly decreased (P<0.05) in HDW group, and the mean survival time of the mice was significantly extended (P<0.05). Hedyotis diffusa directly inhibited the proliferation of cervical cancer cells and induced apoptosis of the tumor cells. It has a positive effect for the treatment of cervical cancer to achieve the goal of clearing the heat, removing the toxins, eliminating the stasis, and dissolving the masses.


Feng C.,Central Hospital of Xuzhou | Wang L.,Central Hospital of Xuzhou
Oncology Letters | Year: 2016

A 69-year-old male patient was admitted to hospital because a lump was discovered, accompanied with pain lasting 5 h under his right scapula. Two months earlier, he had undergone a double-stent insertion operation due to lesions on the end of the left main coronary artery, the opening of left circumflex artery, and the opening of the anterior descending branch. After the operation, he was administered with dual anti-platelet therapy (DAPT) with aspirin and ticagrelor and was diagnosed with hematoma under his right scapula through ultrasonic inspection. It was established that no other factor, except DAPT, was responsible for his spontaneous hematoma. © 2016, Spandidos Publications. All rights reserved.


Xu H.-S.,Central Hospital of Xuzhou | Ma C.,Central Hospital of Xuzhou | Cao L.,Central Hospital of Xuzhou | Wang J.-J.,Central Hospital of Xuzhou | Fan X.-X.,Central Hospital of Xuzhou
European Review for Medical and Pharmacological Sciences | Year: 2014

AIM: The aims of this study are to investigate the effects of co-transplantation Bone Marrow Stromal Stem Cells (BMSCs) and Schwann Cells (SCs) in treating rat traumatic brain injury (TBI), the migration of BMSCs in the brain, and whether co-transplantation treatment is superior to single transplantation. MATERIALS AND METHODS: Superparamagnetic iron oxide (SPIO) labeled BMSCs and SCs were transplanted and co-transplanted into the rats with TBI. The neurological functions of the rats were evaluated by the NSS (Neurological Severity Score) at day 3, 7, 14, and 30. Moreover, 7.0T MRI (Magnetic Resonance Imaging) scan was conducted in order to observe the migration of the labeled BMSCs. RESULTS: MRI scan showed that when SPIO labeled BMSCs were injected into the brain,T2WI (weighted image) showed low signals and these low signals migrated toward the lesion. The speed of migration was faster in the co-transplantation group than in the single transplantation group. NSS results showed that the prognosis was better in the co-transplantation group than in the single transplantation group at day 14 after injection. CONCLUSIONS: The co-transplantation of BMSCs and SCs showed faster cell migration and better prognosis in rat TBI.


Tao L.,Central Hospital of Xuzhou | Xi-lin H.,Central Hospital of Xuzhou | Xiang-dong M.,Central Hospital of Xuzhou
Cell Biochemistry and Biophysics | Year: 2015

The aim of this study is to explore the surgical strategies for treating Hashimoto’s disease complicated with thyroid microcarcinoma. We analyzed the clinical data of 25 patients with Hashimoto’s disease with thyroid microcarcinoma who were treated in our hospital from January 1995 to September 2011. The incidence of Hashimoto’s disease with thyroid microcarcinoma was 9.8 % (25/256) in our hospital. Amongst them, 19 patients had papillary thyroid carcinoma and six had follicular thyroid carcinoma. There were 24 cases (96 %) confirmed by the frozen section examination and one (4 %) after surgery. One patient did not undergo remedial surgery. The surgical approaches were determined based on preoperative examinations and intraoperative frozen pathology, including thyroid lobe and isthmus resection with contralateral lobe subtotal resection in 19 cases, and bilateral subtotal thyroid lobectomy in one case. Central lymph node dissection was conducted for all patients except one who was not diagnosed until after the surgery. No recurrence occurred during the follow-up (range: 6 months to 17 years) and all patients have survived to date. The preoperative diagnosis rate of Hashimoto’s disease with thyroid cancer (in particular thyroid microcarcinomas) is low. Preoperative palpation, color Doppler ultrasound, fine needle aspiration, and the frozen section examination are helpful to improve the diagnosis rate of Hashimoto’s disease with thyroid microcarcinoma. Surgery procedure is the most effective approach. © 2014, Springer Science+Business Media New York.


PubMed | Central Hospital of Xuzhou
Type: Journal Article | Journal: Cell biochemistry and biophysics | Year: 2016

The aim of this study is to explore non-medical factors that determine withdrawal from radiation therapy. Data from 2,643 patients who received radiotherapy in our Hospital from March 2010 to March 2012 were collected. Using gender, age, stage of the disease, Karnofsky score, aim of radiation therapy, therapy technique, vocation, medical insurance, and educational status as variables, 43 patients who terminated radiation therapy due to non-medical causes and 43 who completed the recommended course in the same period of time were, respectively, allocated to study and control groups. Univariate and 1:1 multivariate conditional logistic regression analyses were used to determine the risk facts for treatment withdrawal. Forty-three patients who withdrew from the therapy received at least one and maximally 26 therapy sessions (median of seven). A significant part of therapy withdrawals occurred during the first week and accounted for 37% of therapy withdrawals. Univariate analysis showed that vocation, medical insurance, educational status, stage of the disease, Karnofsky score, aim, and technique of radiation therapy were significant determinants of therapy withdrawal. Furthermore, medical insurance status and stage of the disease were also found to be determinants in the multivariate regression analysis. Medical insurance and stage of the disease were found to be the major determinants that affect withdrawal from radiation therapy.


PubMed | Central Hospital of Xuzhou
Type: Journal Article | Journal: Cell biochemistry and biophysics | Year: 2016

The aim of this study is to explore the surgical strategies for treating Hashimotos disease complicated with thyroid microcarcinoma. We analyzed the clinical data of 25 patients with Hashimotos disease with thyroid microcarcinoma who were treated in our hospital from January 1995 to September 2011. The incidence of Hashimotos disease with thyroid microcarcinoma was 9.8 % (25/256) in our hospital. Amongst them, 19 patients had papillary thyroid carcinoma and six had follicular thyroid carcinoma. There were 24 cases (96 %) confirmed by the frozen section examination and one (4 %) after surgery. One patient did not undergo remedial surgery. The surgical approaches were determined based on preoperative examinations and intraoperative frozen pathology, including thyroid lobe and isthmus resection with contralateral lobe subtotal resection in 19 cases, and bilateral subtotal thyroid lobectomy in one case. Central lymph node dissection was conducted for all patients except one who was not diagnosed until after the surgery. No recurrence occurred during the follow-up (range: 6 months to 17 years) and all patients have survived to date. The preoperative diagnosis rate of Hashimotos disease with thyroid cancer (in particular thyroid microcarcinomas) is low. Preoperative palpation, color Doppler ultrasound, fine needle aspiration, and the frozen section examination are helpful to improve the diagnosis rate of Hashimotos disease with thyroid microcarcinoma. Surgery procedure is the most effective approach.

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