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Tongshan, China

Yuan S.-M.,Central Hospital of Xuzhou | Sternik L.,Chaim Sheba Medical Center
Journal of B.U.ON. | Year: 2012

Purpose: Despite the review articles repeatedly published with respect to mitral valve myxomas, hardly could we find one based upon complete literature retrieval. We took an effort on complete literature retrieval and made a comprehensive review of the mitral valve myxomas. Methods: An instant thorough literature retrieval of the heart myxoma was made by using the MEDLINE and EMBASE databases, as well as secondary references cited in the articles obtained from the MEDLINE search. In addition, we searched the Google and High Wire Press. Results: The patients with mitral valve myxoma were young. Their major symptoms were cerebrovascular, cardiovascular, or constitutional. The tumors had small sizes, predilection of mitral leaflet location, solitary and pedicled nature, and good response to surgical resection. Conclusion: These clinical characteristics of mitral valve myxoma may help the differential diagnosis between mitral valve myxoma and other valvular lesions, and help making a decision of a surgical treatment. © 2012 Zerbinis Medical Publications. Source

Qu D.-W.,Xuzhou Medical College | Xu H.-S.,Central Hospital of Xuzhou | Han X.-J.,Xuzhou Medical College | Wang Y.-L.,Xuzhou Medical College | Ouyang C.-J.,Xuzhou Medical College
European Review for Medical and Pharmacological Sciences | Year: 2014

OBJECTIVES: To investigate the expression of cyclinD1 and Ki-67 proteins in gliomas and its significance. PATIENTS AND METHODS: The immunohistochemistry was used to detect the expression of cyclinD1 and Ki-67 proteins in 18 cases of normal brain tissues, 32 cases of low-grade gliomas, and 24 cases of high-grade gliomas. RESULTS: The cyclinD1 positive ratio in normal brain tissues, low-grade gliomas, and high-grade gliomas were 4/18, 15/32, and 18/24, respectively, with statistically significant difference (p < 0.05). Differences were significant by pairwise comparison between normal brain tissue with high-grade gliomas and low-grade gliomas with high-grade glioma groups (p < 0.01). However, there was no significant differences between normal brain tissue with low-grade gliomas.The Ki-67 positive ratio in normal brain tissues, low-grade gliomas, and high-grade gliomas were 5/18, 21/32, and 20/24, respectively. The difference among three tissues was statistically significant (p < 0.05). Differences were significant by pairwise comparison between normal brain tissue with low-grade gliomas and normal brain tissue with high-grade glioma group (p < 0.01).There is no difference between low-grade gliomas and high-grade gliomas (p > 0.05). Spearman's rank correlation confirmed that cyclinD1 and Ki-67 was positively correlated in low-grade gliomas and high-level brain tumor (p < 0.05), but no correlation in the normal brain tissue (p > 0.05). CONCLUSIONS: The expression of CyclinD1 and Ki-67 increased in gliomas, suggesting that both may play an important role in the occurrence of gliomas. Source

Qi L.,Harvard University | Qi L.,Brigham and Womens Hospital | Liang J.,Central Hospital of Xuzhou
Current Opinion in Lipidology | Year: 2010

Purpose of review: The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D). Recent findings: Several studies reported that dietary factors related to carbohydrate quality and quantity, such as whole grains and glycemic load, might interact with transcription factor 7-like 2 variants in relation to T2D risk. The genetic predisposition defined by the combination of 10 established T2D risk alleles was found to modulate the association between Western dietary pattern (high intakes of red meat, processed meat, and low fiber) and T2D; a stronger association was observed in those with a high-risk genetic profile. Variants in genes HHEX, CDKN2A/2B, JAZF1, and IGF2BP2 were found to interact with prenatal nutrition in relation to T2D risk and glucose levels in later life. Summary: The available data provide preliminary support for the gene-diet interactions in determining T2D. However, most findings have yet to be validated. Future studies will need agreed standards of study design and statistical power, dietary measurement, analytical methods, and replication strategies. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

Zhao H.,Central Hospital of Xuzhou
Chinese Journal of Cerebrovascular Diseases | Year: 2010

Objective: To investigate the role of the protein kinase C (PKC) inhibitor isoquinoline sulfonamides (H-7) on the brain damage following thrombin-induced cerebral hemorrhage in rats. Methods: A total of 54 healthy male SD rats were randomly allocated into 3 groups: control, thrombin, and H-7 intervention groups (n = 18 in each group). Thrombin (10 U, dissolved in 50 μL isotonic saline) was injected into the right caudate nucleus to establish the rat model. Immediately after the modeling procedure and at 24 hours, H-7 (1 mg/kg) was injected intraperitoneally in the H-7 intervention group; equal amount of isotonic saline was injected intraperitoneally in the control group. Hematoxylin and Eosin (HE) staining was used to observe the histopathological changes and inflammatory cell infiltration 48 hours after the modeling, the dye Evans blue assay was used to detect the blood-brain barrier (BBB) permeability, the dry-wet method was used to measure the brain water content, and TUNEL was used to observe the apoptosis in the injuried brain region. Results: Circled digit one Pathological observation showed that H-7 significantly improved brain injury induced by thrombin. Circled digit two The inflammatory cell counts around the right caudate nucleus in the control, thrombin, and H-7 intervention groups were 0.8 ± 0.7, 16.5 ± 1.0, and 10.0 ± 1.4, respectively. The apoptosis cell counts were 73 ± 5, 150 ± 12, and 118 ± 9. The brain water contents were 77.5 ± 1.1, 83.2 ± 0.4, and 78.8 ± 0.9%. The EB contents were 6.7 ± 0.5, 28.4 ± 3.2, and 16.0 ± 1.3 μg/g. When thrombin group compared with the control and H-7 intervention groups, there were significant differences among the above indices (P < 0.05 or P < 0.01). Conclusion: H-7 significantly reduces the brain injury following thrombin-induced cerebral hemorrhage. It may play a neuroprotective role by inhibiting the activation of PKC. Source

Qiao J.,Shanghai JiaoTong University | Chen X.,Shanghai JiaoTong University | Chen X.,Nanjing Medical University | Zuo C.-L.,Shanghai JiaoTong University | And 10 more authors.
Clinical Endocrinology | Year: 2010

Objective P450c17 deficiency (17α-hydroxylase/17,20-lyase deficiency, 17OHD) is a rare form of congenital adrenal hyperplasia caused by CYP17A1 gene mutations. The D487-F489 deletion in exon 8 and Y329fs in exon 6 are relatively frequent mutations of the CYP17A1 gene in China that completely abolish the enzyme activity of P450c17. However, little remains known about steroid biosynthetic functions in carriers with these mutations in a single allele of the CYP17A1 gene, who are assumed to have 50% P450c17 activity. We investigated adrenal steroidogenic function in genotype-proven heterozygotes carrying such mutations in the CYP17A1 gene in vivo. Patients and design Eight patients and fourteen family members from five families with 17OHD were recruited. The mutations of the CYP17A1 gene in these individuals were screened by sequencing. The hormonal response to cosyntropin (ACTH) was evaluated in the 14 genotype-proven carriers and 45 age- and gender-matched normal controls. Results Fourteen carriers of the CYP17A1 mutation - seven with the D487-F489 deletion, six with Y329fs and one with H373L - were identified from the five families with 17OHD. Compared with normal controls, carriers showed lower basal and ACTH-stimulated cortisol levels but higher ACTH-stimulated corticosterone levels. The ratios of corticosterone to cortisol in the genotype-proven heterozygotes were higher than those of the normal controls at the baseline and after cosyntropin stimulation. Similarly, the progesterone levels and the ratios of progesterone to 17-hydroxyprogesterone in the male heterozygotes were also higher than those of the normal controls, both before and after ACTH stimulation. Conclusion Genotype-proven carriers of the CYP17A1 mutation who lack apparent clinical symptoms exhibit decreased adrenal 17α-hydroxylase activity and altered adrenal gland reserve for steroid biosynthesis. © 2010 Blackwell Publishing Ltd. Source

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