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He Z.-Y.,Sun Yat Sen University | Chi F.,Sun Yat Sen University | Li F.-Y.,Sun Yat Sen University | Wang J.-J.,Central Hospital of Xinxiang | And 2 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2011

OBJECTIVE: To evaluate the dosimetry advantages of moderate deep inspiration breath hold (mDIBH) achieved using an active breathing control (ABC) device in the target of forward whole-breast intensity-modulated radiotherapy after breast conserving surgery in breast cancer. METHODS: 18 patients after breast conserving surgery had received primary CT-simulation assisted by ABC to get two sets of CT image on the two breathing conditions which included one set from free breath (FB), and the other set from mDIBH. Forward whole-breast intensity-modulated radiotherapy plans were carried out in each set of CT image using Pinnacle7. 4 f planning systems and the differences of two plans had been compared. RESULTS: The coverage index and habituation index of the plans in FB were similar with those in mDIBH (1. 08±0. 01) vs (1. 09±0. 01), P = 0. 776; 0. 59±0. 08 vs 0. 60±0. 04, P = 0.821). The V 20 and V 30 of Ipsi-lateral lung in FB were higher than those in mDIBH (13. 07± 3. 93)% vs (9. 75±3. 58)%, (11. 68±3. 90)% vs (8. 12± 3. 23)%, P = 0.000; In the left breast cancer, The V 20 and V 30 of heart in FB were higher than those in mDIBH (5. 42±3. 21)% vs (2. 73±1.95)%, (3. 70±2. 84)% vs (1. 48±0. 22)%, P<0. 05. CONCLUSION: Compared with FB, mDIBH achieved using an ABC device significantly reduces heart and lung doses in the target of forward whole-breast intensity-modulated radiotherapy after breast conserving surgery in breast cancer.

Wang G.,Henan Normal University | Li B.,Central Hospital of Xinxiang | Hao Y.,Henan Normal University | Hao Y.,Key Laboratory for Cell Differentiation Regulation | And 6 more authors.
Cell Biology International | Year: 2013

To explore the relevance of non-alcoholic fatty liver disease (NAFLD) to liver regeneration (LR), rat models of non-alcoholic steatohepatitis (NASH) and LR were established, respectively, then Rat Genome 230 2.0 Array was used to detect the gene expression abundance of them, and the reliabilities of the array data were confirmed by real-time RT-PCR. As a result, the expression of 93 genes was significantly changed during NAFLD occurrence and 948 genes in LR. Hierarchical clustering indicated that the expression profiles of the above two events were quite different. K-means cluster classified their expression patterns into four clusters, and gene expression trends of clusters 1, 2 were similar in NAFLD and LR, while clusters 3, 4 were contrary with the gene expression changes of LR more abundant. DAVID classifications and functional enrichment analysis found that lipid metabolism and carbohydrate metabolism were stronger in NAFLD than in LR, but some other physiological activities including inflammation/immune response, cell adhesion, and migration, cell proliferation and differentiation in NAFLD were weaker than in LR. IPA further indicated that lipid metabolism, inflammation response, and cellular development were highly associated with NAFLD, and thus identified some potential biomarkers for NAFLD. © 2013 International Federation for Cell Biology.

Yang W.,Central Hospital of Xinxiang | Hu W.-L.,Central Hospital of Xinxiang
Pakistan Journal of Medical Sciences | Year: 2015

Objective: To evaluate the effects of intravenously infused lidocaine on analgesia and gastrointestinal function of patients receiving laparoscopic common bile duct exploration. Methods: Seventy-eight patients with cholelithiasis were randomly divided into a treatment group and a control group (n=39) that all had laparoscopic common bile duct exploration. The treatment group was intravenously infused with 1.5 mg/kg lidocaine by using a venous pump under anesthesia induction at the speed of 2 mg·kg-1·h-1 until the end of surgery, while the control group was given normal saline with the same volume. Results: All patients successfully completed the surgery, with similar surgical time, incision length and intraoperative blood loss. The required lidocaine concentrations of the treatment group were 2.64±1.23 μg/ ml, 1.14±0.4 μg/ml and 0.93±0.32 μg/ml respectively 2 hour, 12 hour and 48 hour after surgery. Pain score of the treatment group, which was significantly lower than that of the control group at the postoperative 2 hour (P<0.05), was similar to those of the control group at the postoperative 12 hour and 48 hour. With extended time, the pain score significantly decreased (P<0.05). The treatment group had significantly shorter first anal exhaust time and first defecation time than those of the control group (P<0.05). Adverse reactions, such as nausea and vomiting, dizziness, headache, subcutaneous emphysema and fat liquefaction of incision, occurred similarly in the two groups, which were alleviated by symptomatic treatment. Conclusion: Laparoscopic common bile duct exploration is a promising minimally invasive surgery for patients with cholelithiasis, during which intravenously infused lidocaine can rapidly recover the gastrointestinal function and exert short-term analgesic effects, with mild adverse reactions also. © 2015, Professional Medical Publications. All rights reserved.

Ren G.,Central Hospital of Xinxiang | Wang B.,Central Hospital of Xinxiang | Wang Y.,Central Hospital of Xinxiang
Pakistan journal of pharmaceutical sciences | Year: 2016

To study the obstetric emergency hysterectomy which can reduce the incidence of measures. In maternity of Xinxiang Central Hospital, the total number of deliveries cases has been up to 50,526 in 20 years, of which 48 cases were retrospectively analyzed for the clinical data of Emergency uterine surgery cases. Cases underwent obstetric emergency hysterectomy accounted for 0.095% of total deliveries (48/50 526), in which 11 cases of vaginal delivery, 37 cases of cesarean section. The indications for surgery: 27 cases were cased by placental factors accounted for 56.25%; 14 cases of uterine inertia, accounting for 29.17%; uterine rupture in 4 cases, accounting for 8.33%; 3 cases of coagulopathy, accounting for 6.25%. Where the maternal placental factors hysterectomy is the most common (69.70%, 23/33) and the predominant factor is early maternal uterine inertia (60.00%, 9/15). There are 74.09% (20/27) of patients with placental abnormalities history of previous cesarean section or uterine surgery. The major risk factors leading to obstetric emergency hysterectomy is placental factors. Preventing the occurrence of placental abnormalities planting actively can effectively reduce the rate of obstetric hysterectomy.

Yin J.-J.,Central Hospital of Xinxiang | Zhan X.-R.,Central Hospital of Xinxiang | Wang Y.,Central Hospital of Xinxiang | Kong Y.-K.,Central Hospital of Xinxiang
Journal of Leukemia and Lymphoma | Year: 2010

Objective: To observe the effects of different dosages of granulocyte-macrophage colony-stimulating factor (GM-CSF) on generating the murine bone marrow dendritic cells, and supply suitable dosage of GM-CSF on preparation of dendritic cell vaccines used for different purpose. Methods: Using low (5 ng/ml) and conventional (20 ng/ml) and high dosage( 50 ng/ml ) of GM-CSF combined interleukin-4 (IL-4) to induce murine bone marrow dendritic cells were performed, The phenotypes (CD11c, CD80, CD 86) and functional properties of the DC were compared by FACS analysis and MLR. Results: The DC induced by low dosage of GM-CSF were immature DC, expressing low CD11c, CD80, and CD86. DC induced by conventional dosage were functional mature, expressing higher CD 11c, CD80, CD86, which could induce allogeneic T lymphocyte responses. DC induced by the high dosage GM-CSF were the most phetotypically and functional mature cells, expressing the highest CD 11c, CD80, CD86, which could induce the strongest allogeneic T lymphocyte responses. Conclusion: The dosages of GM-CSF affect the maturation stage of dendritic cells. Low dosage of GM-CSF generated immature dendritic cells, but conventional dosage and high dosage generated mature dendritic cells. DC generated through high dosage of GM-CSF were the most mature in phenotype and function.

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