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Liu J.,Central Hospital of Enshi Prefecture
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To investigate aeroallergen spectrum of patients with allergic rhinitis in Enshi area and analyze its related factors. Skin prick test was carried out in 463 patients with allergic rhinitis with 13 inhaled allergens. Detailed history was collected in all cases. Three hundred and eighty-seven cases (83.6%) showed positive reaction to at least one allergen of 13 allergens. The most common allergens found in patients were Dermatophagoides farinae and Dermatophagoides pteronyssinus, followed by tropical mite, Periplaneta americana, Blattella germanica and dog hair. The positive reaction rate of single specie allergen were 51.9%, and most of them was positive to mites (49.6%). The positive reaction degree was significantly related to family history, asthma, age and housing enviroment. The major allergen of allergic rhinitis was mite. The positive reaction degree related to genetics, asthma, age and housing enviroment. Source

Wang S.,Hubei University for Nationalities | Li Y.,Hubei University for Nationalities | Liu X.-D.,Hubei University for Nationalities | Zhao C.-X.,Central Hospital of Enshi Prefecture | Yang K.-Q.,Hubei University for Nationalities
International Journal of Clinical Oncology | Year: 2013

Background: Previous studies have indicated a direct effect of μ-opioid receptors on tumor progression or recurrence. An A118G polymorphism in the μ-opioid receptor gene was believed to play an important role in this carcinogenic process. The aim of the present study was to investigate the association between the A118G polymorphism and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population. Method: The case-control study included 260 cancer patients and 291 controls from a Chinese Han and Chinese TuJia population in Enshi region, China. Genotypes were determined by TaqMan platform. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using multivariate unconditional logistic regression. Results: Compared with the G/G genotype, the A/A genotype exhibited a significantly elevated risk for ESCC (OR = 3.12, 95 % CI [1], 1.11-6.01). A significant interaction between the A118G polymorphism and age, smoking status, and family history of cancer was also found (OR = 2.25, 95 % CI 1.36-4.12; OR = 1.75, 95 % CI 1.23-2.32; OR = 3.14, 95 % CI 1.31-7.28, respectively). Conclusion: The A118G polymorphism in the μ-opioid receptor gene might be associated with the risk of ESCC in Chinese population. © 2012 Japan Society of Clinical Oncology. Source

Chen H.B.,Central Hospital of Enshi Prefecture
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To study the inhibitory effect of Akt inhibitor deguelin on PC-3 human prostate cancer cell lines and its possible mechanism. PC-3 human prostate cancer cells were cultured in deguelin at the concentrations of 10, 100, 500 and 1 000 nmol/L for 24, 48 and 72 hours, respectively. Then the inhibitory effect of deguelin on the proliferation of the PC-3 cells was determined by MTT assay and that on the cell cycle was detected by flow cytometry. The expression levels of MDM2 and GSK3beta mRNA were measured by RT-PCR and those of MDM2 and GSK3beta proteins by Western blot. At 24, 48 and 72 hours, the inhibition rates of deguelin on the proliferation of the PC-3 prostate cancer cells were (91.10 +/- 3.75), (86.39 +/- 1.16) and (79.51 +/- 2.63)% at 10 nmol/L, (82.46 +/- 3.65), (76.84 +/- 0.97) and (69.69 +/- 2.30) % at 100 nmol/L, (81.46 +/- 0.41), (75.56 +/- 1.12) and (54.07 +/- 3.21)% at 500 nmol/L, and (66.77 +/- 2.82), (58.22 +/- 0.35) and (39.34 +/- 2.40)% at 1000 nmol/L, all with statistically significant differences from the control group (P < 0.01). Deguelin at 10, 100, 500 and 1 000 nmol/L increased the cell cycles blocked in the G0/G1 phase ([62.4 +/- 2.2], [63.6 +/- 1.1 ], [65.0 +/- 0.3] and [66.5 +/- 1.9]%, P < 0.01) and reduced the percentage of the S-phase cells ([14.7 +/- 2.4], [11.1 +/- 5.2], [5.8 +/- 1.1] and [7.0 +/- 0.6]%, P < 0.01). RT-PCR and Western blot showed markedly up-regulated expressions of GSK3 P3 a3beta down-regulated expressions of MDM2 mRNA and proteins in the PC-3 cells treated with deguelin. Akt inhibitor deguelin can inhibit the proliferation of PC-3 human prostate cancer cells by affecting the down-stream signal molecules GSK3P3 and betaDM2 in the Akt pathway. Source

Liu J.,Central Hospital of Enshi Prefecture
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

Comparing the difference between the effect of comprehensive treatment and that of radiotherapy only in laryngopharyngeal carcinoma cases. Analyzing clinical data of 68 cases of laryngopharyngeal carcinoma treated in our department from June 2003 to December 2009. Among them, 40 cases were treated by comprehensive treatment of surgery combined with radiotherapy (group A), 28 cases by radiotherapy only (group B). The three-year survival rate of group A and B were 75.6% (31/41) and 26.7% (4/15), respectively, and the five-year survival rate of the two groups were 56.1% (23/41) and 13.3% (2/15), respectively. For laryngopharyngeal carcinoma cases, the therapeutic effect of comprehensive treatment was much better than that of the radiotherapy only, not only could improve the survival rate, but also could make the life quality after treatment better. Source

Chen J.,Huazhong University of Science and Technology | Li B.,Huangshi Central Hospital | Zhao Y.,First Peoples Hospital of Jingmen | Zhang Q.,Huazhong University of Science and Technology | And 23 more authors.
American Journal of Rhinology and Allergy | Year: 2014

Background: Standardized allergen-specific immunotherapy (SIT) has been used in China for years. However, there is no extensive study of the safety of standardized SIT in Chinese patients until now. The aim of the current study is to perform a prospective and multicenter study to evaluate the systemic reactions (SRs) of standardized SIT in Chinese patients. Methods: The study was performed in 13 allergy centers in China, using the same vaccine and practice procedure. The length of observation period was 2 years. SRs were recorded and analyzed. Results: There were 666 patients included (261 children and 405 adults). All patients finished the initial phase and 47 patients withdrew during the maintenance phase. There were 0.47% (94/19,963) SRs in all injections (0.72% in children and 0.31% in adults); 8.26% (55/666) patients experienced SRs (12.26% children and 5.68% adults). The occurrence of SRs was significantly higher in children than that in adults (p < 0.01). A higher ratio of SRs was found among patients accompanied with asthma. There were 74.47% SRs of grade I, 15.96% SRs of grade II, 7.45% SRs of grade III, and 2.13% SRs of grade IV. There were 90.43% of SRs associated with the discomfort of lower respiratory tract. Conclusion: This multicenter study showed that properly conducted standardized SIT was a safe treatment for allergic rhinitis in China. The incidence of SRs was higher in children than that in adults. Copyright © 2014, OceanSide Publications, Inc. Source

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