Central Hospital of Enshi Prefecture

Enshi, China

Central Hospital of Enshi Prefecture

Enshi, China

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Chen J.,Huazhong University of Science and Technology | Zhao Y.,First Peoples Hospital of Jingmen | Li B.,Huangshi Central Hospital | Zhang Q.,Huazhong University of Science and Technology | And 23 more authors.
American Journal of Rhinology and Allergy | Year: 2014

Methods: A multicenter investigation was performed in 13 allergy centers in central China. A disease-related questionnaire was completed by each patient themselves or with guardian assistance after the diagnosis of AR. The clinical features of AR and allergen profile were analyzed.Background: Several epidemiological surveys of allergic rhinitis (AR) have been conducted in China. However, the clinical features of AR are still not clear enough. The aim of the current study was to perform a multicenter investigation to evaluate the clinical features of AR in China.Results: Eleven thousand four patients who were diagnosed with AR were recruited in this study. The percentages of classification of AR according to the Allergic Rhinitis and Its Impact on Asthma guidelines were 9.7% intermittent mild (IM), 3.1% persistent mild (PM), 33.9% intermittent moderate-severe (IMS), and 53.3% persistent moderate-severe (PMS). There were 61.6 and 42.2% AR patients who had concomitant ocular or lower respiratory symptoms in clinic. The occurrence of ocular and lower respiratory symptoms was found to be gradually increased from IM, PM, and IMS to PMS. Cold air and temperature change were the two most common factors triggering the nasal symptoms. Dermatophagoides pteronyssinus and Dermatophagoides farinae were the most important allergens of central China. Conclusions: This study has contributed to a better understanding of clinical features of AR in China. © 2014, OceanSide Publications, Inc., U.S.A.


Liu J.,Central Hospital of Enshi Prefecture
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To investigate aeroallergen spectrum of patients with allergic rhinitis in Enshi area and analyze its related factors. Skin prick test was carried out in 463 patients with allergic rhinitis with 13 inhaled allergens. Detailed history was collected in all cases. Three hundred and eighty-seven cases (83.6%) showed positive reaction to at least one allergen of 13 allergens. The most common allergens found in patients were Dermatophagoides farinae and Dermatophagoides pteronyssinus, followed by tropical mite, Periplaneta americana, Blattella germanica and dog hair. The positive reaction rate of single specie allergen were 51.9%, and most of them was positive to mites (49.6%). The positive reaction degree was significantly related to family history, asthma, age and housing enviroment. The major allergen of allergic rhinitis was mite. The positive reaction degree related to genetics, asthma, age and housing enviroment.


Wang S.,Hubei University for Nationalities | Li Y.,Hubei University for Nationalities | Liu X.-D.,Hubei University for Nationalities | Zhao C.-X.,Central Hospital of Enshi Prefecture | Yang K.-Q.,Hubei University for Nationalities
International Journal of Clinical Oncology | Year: 2013

Background: Previous studies have indicated a direct effect of μ-opioid receptors on tumor progression or recurrence. An A118G polymorphism in the μ-opioid receptor gene was believed to play an important role in this carcinogenic process. The aim of the present study was to investigate the association between the A118G polymorphism and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population. Method: The case-control study included 260 cancer patients and 291 controls from a Chinese Han and Chinese TuJia population in Enshi region, China. Genotypes were determined by TaqMan platform. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using multivariate unconditional logistic regression. Results: Compared with the G/G genotype, the A/A genotype exhibited a significantly elevated risk for ESCC (OR = 3.12, 95 % CI [1], 1.11-6.01). A significant interaction between the A118G polymorphism and age, smoking status, and family history of cancer was also found (OR = 2.25, 95 % CI 1.36-4.12; OR = 1.75, 95 % CI 1.23-2.32; OR = 3.14, 95 % CI 1.31-7.28, respectively). Conclusion: The A118G polymorphism in the μ-opioid receptor gene might be associated with the risk of ESCC in Chinese population. © 2012 Japan Society of Clinical Oncology.


Li X.,Central Hospital of Enshi Prefecture | Li H.-Y.,Central Hospital of Enshi Prefecture | Bao Y.-Z.,Central Hospital of Enshi Prefecture
International Journal of Ophthalmology | Year: 2010

• AIM: To evaluate the efficacy of multilayer amniotic membrane transplantation combined with antivirus and glucocorticosteroid drug to treat necrotizing herpes simplex stromal keratitis. • METHODS: Eighteen patients (18 eyes) of necrotizing herpes simplex stromal keratitis were referred to the central hospital of Enshi Autonomous Prefecture between October 2002 and October 2009. Corneal inflammation persisted and corneal ulcer progressed despite topical and systemic antiviral treatment for over 1 week. Multilayer fresh amniotic transplantation was performed, and combined with antivirus and glucocorticosteroid drug after operation. • RESULTS: Corneal ulcer healed after operation. Corneal transparence was achieved in 8 cases, partial corneal leucoma or macula in 10 cases. 1 of these patients, whose ulcer progressed to hole, adherent leucoma was formed, and corneal transplant was performed in 1 year. • CONCLUSION: Multilayer fresh amniotic transplantation combined with antivirus and glucocorticosteroid treatment is an efficient method to treat necrotizing stromal keratitis. The method can recover some visual acuity, or keep the integrity of cornea for corneal transplantation.


Chen H.B.,Central Hospital of Enshi Prefecture
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To study the inhibitory effect of Akt inhibitor deguelin on PC-3 human prostate cancer cell lines and its possible mechanism. PC-3 human prostate cancer cells were cultured in deguelin at the concentrations of 10, 100, 500 and 1 000 nmol/L for 24, 48 and 72 hours, respectively. Then the inhibitory effect of deguelin on the proliferation of the PC-3 cells was determined by MTT assay and that on the cell cycle was detected by flow cytometry. The expression levels of MDM2 and GSK3beta mRNA were measured by RT-PCR and those of MDM2 and GSK3beta proteins by Western blot. At 24, 48 and 72 hours, the inhibition rates of deguelin on the proliferation of the PC-3 prostate cancer cells were (91.10 +/- 3.75), (86.39 +/- 1.16) and (79.51 +/- 2.63)% at 10 nmol/L, (82.46 +/- 3.65), (76.84 +/- 0.97) and (69.69 +/- 2.30) % at 100 nmol/L, (81.46 +/- 0.41), (75.56 +/- 1.12) and (54.07 +/- 3.21)% at 500 nmol/L, and (66.77 +/- 2.82), (58.22 +/- 0.35) and (39.34 +/- 2.40)% at 1000 nmol/L, all with statistically significant differences from the control group (P < 0.01). Deguelin at 10, 100, 500 and 1 000 nmol/L increased the cell cycles blocked in the G0/G1 phase ([62.4 +/- 2.2], [63.6 +/- 1.1 ], [65.0 +/- 0.3] and [66.5 +/- 1.9]%, P < 0.01) and reduced the percentage of the S-phase cells ([14.7 +/- 2.4], [11.1 +/- 5.2], [5.8 +/- 1.1] and [7.0 +/- 0.6]%, P < 0.01). RT-PCR and Western blot showed markedly up-regulated expressions of GSK3 P3 a3beta down-regulated expressions of MDM2 mRNA and proteins in the PC-3 cells treated with deguelin. Akt inhibitor deguelin can inhibit the proliferation of PC-3 human prostate cancer cells by affecting the down-stream signal molecules GSK3P3 and betaDM2 in the Akt pathway.


Chen D.,Central Hospital of Enshi Prefecture | Lai L.,Central Hospital of Enshi Prefecture | Duan C.,Central Hospital of Enshi Prefecture | Yan M.,Central Hospital of Enshi Prefecture | And 3 more authors.
Clinical Breast Cancer | Year: 2014

Background The objective of this study was to explore the effect of conservative surgery plus postoperative axillary radiotherapy without axillary lymph node dissection vs. modified radical mastectomy in patients with stage I breast cancer. Patients and Methods In this study, 186 patients with stage I breast cancer were enrolled. Among them, 98 patients underwent breast-conserving surgery without axillary node dissection. From the first day after surgery, each of them received 6 cycles of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy, and thereafter radical radiotherapy for 5 to 6 weeks. Eighty-eight patients received modified radical mastectomy with postoperative chemotherapy and radiotherapy. The clinical data of these 186 patients were analyzed. Results There was no significant difference (P >.05) in local recurrence and survival rates between the conservative plus axillary radiotherapy group and the modified radical mastectomy group, although a significantly greater incidence of upper limb dysfunction and edema were observed in the modified mastectomy group (P <.05). Conclusion The efficacy of conservative surgery plus axillary radiotherapy alone is superior to that of axillary node dissection for stage I breast cancer patients. © 2014 Elsevier Inc. All rights reserved.


Liu J.,Central Hospital of Enshi Prefecture
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

Comparing the difference between the effect of comprehensive treatment and that of radiotherapy only in laryngopharyngeal carcinoma cases. Analyzing clinical data of 68 cases of laryngopharyngeal carcinoma treated in our department from June 2003 to December 2009. Among them, 40 cases were treated by comprehensive treatment of surgery combined with radiotherapy (group A), 28 cases by radiotherapy only (group B). The three-year survival rate of group A and B were 75.6% (31/41) and 26.7% (4/15), respectively, and the five-year survival rate of the two groups were 56.1% (23/41) and 13.3% (2/15), respectively. For laryngopharyngeal carcinoma cases, the therapeutic effect of comprehensive treatment was much better than that of the radiotherapy only, not only could improve the survival rate, but also could make the life quality after treatment better.


PubMed | Central Hospital of Enshi Prefecture
Type: Comparative Study | Journal: Clinical breast cancer | Year: 2014

The objective of this study was to explore the effect of conservative surgery plus postoperative axillary radiotherapy without axillary lymph node dissection vs. modified radical mastectomy in patients with stage I breast cancer.In this study, 186 patients with stage I breast cancer were enrolled. Among them, 98 patients underwent breast-conserving surgery without axillary node dissection. From the first day after surgery, each of them received 6 cycles of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy, and thereafter radical radiotherapy for 5 to 6 weeks. Eighty-eight patients received modified radical mastectomy with postoperative chemotherapy and radiotherapy. The clinical data of these 186 patients were analyzed.There was no significant difference (P > .05) in local recurrence and survival rates between the conservative plus axillary radiotherapy group and the modified radical mastectomy group, although a significantly greater incidence of upper limb dysfunction and edema were observed in the modified mastectomy group (P< .05).The efficacy of conservative surgery plus axillary radiotherapy alone is superior to that of axillary node dissection for stage I breast cancer patients.


PubMed | Central Hospital of Enshi Prefecture
Type: Journal Article | Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To investigate aeroallergen spectrum of patients with allergic rhinitis in Enshi area and analyze its related factors.Skin prick test was carried out in 463 patients with allergic rhinitis with 13 inhaled allergens. Detailed history was collected in all cases.Three hundred and eighty-seven cases (83.6%) showed positive reaction to at least one allergen of 13 allergens. The most common allergens found in patients were Dermatophagoides farinae and Dermatophagoides pteronyssinus, followed by tropical mite, Periplaneta americana, Blattella germanica and dog hair. The positive reaction rate of single specie allergen were 51.9%, and most of them was positive to mites (49.6%). The positive reaction degree was significantly related to family history, asthma, age and housing enviroment.The major allergen of allergic rhinitis was mite. The positive reaction degree related to genetics, asthma, age and housing enviroment.


PubMed | Central Hospital of Enshi Prefecture
Type: Comparative Study | Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

Comparing the difference between the effect of comprehensive treatment and that of radiotherapy only in laryngopharyngeal carcinoma cases.Analyzing clinical data of 68 cases of laryngopharyngeal carcinoma treated in our department from June 2003 to December 2009. Among them, 40 cases were treated by comprehensive treatment of surgery combined with radiotherapy (group A), 28 cases by radiotherapy only (group B).The three-year survival rate of group A and B were 75.6% (31/41) and 26.7% (4/15), respectively, and the five-year survival rate of the two groups were 56.1% (23/41) and 13.3% (2/15), respectively.For laryngopharyngeal carcinoma cases, the therapeutic effect of comprehensive treatment was much better than that of the radiotherapy only, not only could improve the survival rate, but also could make the life quality after treatment better.

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