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Hu S.L.,Information Center | Chi J.Q.,Information Center | Guo Z.,Central Hospital of Cangzhou
MATEC Web of Conferences

Objective: Promote further utilization of information technology in quality control of the electronic medical record and provide forceful technological supports for medical quality control. Method: research existing problems in quality control of electronic medical record at present, put forward that the information technology should be used sufficiently, integration with other systems should be completed, quality control rules should be built and quality control time should be set and finally point out the key construction element of information technology to provide supports. Result: The article points out that further utilization of information technology in quality control of EMR should start from the standard, structuralized and paperless electronic medical record, construction of the communication platform and application of high technology. Conclusion: it is of great significance to promote improvement of quality control level of the electronic medical record and improve continuously medical quality. © Owned by the authors, published by EDP Sciences, 2016. Source

Wang L.,PLA Fourth Military Medical University | Wang S.,Central Hospital of Cangzhou | Gao T.,PLA Fourth Military Medical University | Wang G.,PLA Fourth Military Medical University
European Journal of Dermatology

Background: Eccrine angiomatous hamartoma (EAH) is recognized as a vascular hamartoma composed of abnormal proliferation of blood vessels and eccrine glands. Objective: We sought to investigate the immunohistochemical results of D2-40 and Prox1 in EAH in order to gain further insight into its histogenesis. Materials and methods: We collected 21 cases of EAH diagnosed in a dermatology department. Immunohistochemical staining of D2-40 and Prox1 was performed on all cases. Results: Prox1 was universally positive in the endothelial cells of proliferated vessels in all cases. D2-40 was universally positive in the endothelial cells of proliferated vessels in 3 cases, focally positive in 18 cases. Conclusion: EAH is a lymphatic proliferation and therefore we suggest the name of eccrine lymphangiomatous hamartoma. Source

Xia H.-C.,Ningxia Medical University | Wang F.,First Peoples Hospital of Jingmen | Li Y.-H.,Ningxia Medical University | Li Z.-K.,Ningxia Medical University | And 3 more authors.
Future Neurology

Per2 plays a key role in regulating the circadian rhythm in mammals. However, the circadian clock gene expression of Per1 and Per2 and its influence on radiotherapeutic sensitivity of C6 glioma cells in vitro have not been explored. Aim: To investigate the rhythm expression of circadian gene Per1 and Per2, and examine the influence on radiotherapeutic sensitivity of two important clock genes in C6 glioma cells. Materials & methods: The cultured C6 glioma cells and NIH3T3 cells were stimulated by phorbol 12-myristate 13-acetate (PMA). The expression of Per1 and Per2 at the indicated times were examined with a method for the absolute quantification of cDNA using real-time PCR. The cultured cell were given x-irradiation at the indicated times and the cell-cycle, apoptosis and proliferation were examined by flow cytometry. Results: We report here that PMA treatment of C6 rat glioma cells induces circadian expression of Per2, and that during periods of high expression, cells are blocked at the G2/M transition and are more sensitive to x-irradiation. PMA treatment of NIH3T3 cells induced circadian expression of Per1 and Per2, but high Per expression did not block the cell cycle or render the cells more sensitive to irradiation. Conclusion: Our results suggest that Per2 expression may increase the efficacy of radiotherapy against glioma. © 2012 Future Medicine Ltd. Source

Li A.-N.,Hebei Engineering and Technical College | Hu S.-L.,Central Hospital of Cangzhou
Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014

Purpose: Promote the development of paperless electronic prescription. Method: Studies on the advantages of paperless electronic prescription and a number of problems found in its legal status; electronic special prescription; the color of a special prescription; the protection of the right to know to patient; verification and safety of special project. Results: Put forward to the solutions, i.e., Improvement of laws and regulations; application of electronic signature; setting up a CA certification agency subject to hygienic industry; inputting the system of drug rational use; setting up a personalized prescription template; improvement of the management system, formulation of emergency plans; installation of self-service equipment. Conclusion: This paper plays a very important significance to set up a high-quality digital hospital. © 2015 Taylor & Francis Group, London, UK. Source

Wu J.,Harbin Medical University | Xiao Z.,Harbin Medical University | Zhao X.,Central Hospital of Cangzhou | Wu X.,Harbin Medical University
Molecular Medicine Reports

Cholangiocarcinoma (CC) is a rapidly lethal malignancy and currently is considered to be incurable. Biomarkers related to the development of CC remain unclear. The present study aimed to identify differentially expressed genes (DEGs) between normal tissue and intrahepatic CC, as well as specific gene expression patterns that changed together with the development of CC. By using a two-way analysis of variance test, the biomarkers that could distinguish between normal tissue and intrahepatic CC dissected from different days were identified. A k-means cluster method was used to identify gene clusters associated with the development of CC according to their changing expression pattern. Functional enrichment analysis was used to infer the function of each of the gene sets. A time series analysis was constructed to reveal gene signatures that were associated with the development of CC based on gene expression profile changes. Genes related to CC were shown to be involved in 'mitochondrion' and 'focal adhesion'. Three interesting gene groups were identified by the k-means cluster method. Gene clusters with a unique expression pattern are related with the development of CC. The data of this study will facilitate novel discoveries regarding the genetic study of CC by further work. Source

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