Central Hospital of Cangzhou
Central Hospital of Cangzhou
Yansheng W.,Central Hospital of Cangzhou |
Liu C.,Peoples Hospital of Weifang |
Jianchun W.,Central Hospital of Cangzhou |
Yang Z.,Central Hospital of Cangzhou |
Chen L.,Central Hospital of Cangzhou
Oncology Reports | Year: 2017
The aim of this study was to elucidate the effects of iodine-131 on the induction of apoptosis in human cardiac muscle cells and the underlying molecular mechanisms. We found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, PIDD, t-BID (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased Bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells. Meanwhile, si-p53 inhibited the effects of iodine-131 on the reduction in cell proliferation and induction of apoptosis in human cardiac muscle cells through regulation of Bax/cytochrome c/caspase-3 and PIDD/caspase-2/t-BID/cytochrome c/caspase-3 signaling pathway. After si-Bax reduced the effects of iodine-131, it reduced cell proliferation and induced apoptosis in human cardiac muscle cells through the cytochrome c/caspase-3 signaling pathway. However, si-caspase-2 also reduced the effects of iodine-131 on the reduction of cell proliferation and induction of apoptosis in human cardiac muscle cells through the t-BID/cytochrome c/caspase-3 signaling pathway. These findings demonstrated that iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/t-BID/cytochrome c/caspase-3 signaling pathway.
Hu S.L.,Central Hospital of Cangzhou |
Chi J.Q.,Central Hospital of Cangzhou |
Guo Z.,Central Hospital of Cangzhou
MATEC Web of Conferences | Year: 2016
Objective: Promote further utilization of information technology in quality control of the electronic medical record and provide forceful technological supports for medical quality control. Method: research existing problems in quality control of electronic medical record at present, put forward that the information technology should be used sufficiently, integration with other systems should be completed, quality control rules should be built and quality control time should be set and finally point out the key construction element of information technology to provide supports. Result: The article points out that further utilization of information technology in quality control of EMR should start from the standard, structuralized and paperless electronic medical record, construction of the communication platform and application of high technology. Conclusion: it is of great significance to promote improvement of quality control level of the electronic medical record and improve continuously medical quality. © Owned by the authors, published by EDP Sciences, 2016.
Hu S.L.,Central Hospital of Cangzhou |
Chi J.Q.,Central Hospital of Cangzhou
MATEC Web of Conferences | Year: 2016
The purpose of this study is to drive the EMR's further application and rapid expansion clinically based on the electronic medical advice as the core thereby realizing the paperless EMR. This paper has analyzed the implementation effects of electronic medical advice, followed by discussion of frequently asked questions (FAQ) and development direction, and finally analyzed the solution of paperless EMR. It indicates that electronic signatures and unitrust time stamp are keys to achieve the paperless EMR. The laws and regulations, new ideas, paperless consultation sheets, all data integration and sharing, virtual printing technology, application of wireless and mobile ward-round trolley, etc. within the health care field shall be proposed to be improved. It is significantly important to save the medical costs, reduce the medical negligence, achieve the paperless EMR and build a high-quality digital hospital. © 2016 The Authors, published by EDP Sciences.
Li A.-N.,Hebei Engineering and Technical College |
Hu S.-L.,Central Hospital of Cangzhou
Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014 | Year: 2015
Purpose: Promote the development of paperless electronic prescription. Method: Studies on the advantages of paperless electronic prescription and a number of problems found in its legal status; electronic special prescription; the color of a special prescription; the protection of the right to know to patient; verification and safety of special project. Results: Put forward to the solutions, i.e., Improvement of laws and regulations; application of electronic signature; setting up a CA certification agency subject to hygienic industry; inputting the system of drug rational use; setting up a personalized prescription template; improvement of the management system, formulation of emergency plans; installation of self-service equipment. Conclusion: This paper plays a very important significance to set up a high-quality digital hospital. © 2015 Taylor & Francis Group, London, UK.
Hu S.L.,Central Hospital of Cangzhou
Computing, Control, Information and Education Engineering - Proceedings of the 2015 2nd International Conference on Computer, Intelligent and Education Technology, CICET 2015 | Year: 2015
Object: Promote the professional skills of medical staff and improve the work efficiency of hospitals. Method: Expound the advantages and technologies of online examination system of medical science, as well as its functions such as user management, system settings, test bank management, powerful autonomous learning ability, test paper composition, marking, score management, statistic analysis, import and export, anti-cheating. Result: The article analyzes the problems that may occur in the process of operating the system as well as the corresponding solutions. Conclusion: It is of great significance to apply the online examination system of medical science in hospitals. © 2015 Taylor & Francis Group, London.
Yu J.,Central Hospital of Cangzhou |
Li R.,Central Hospital of Cangzhou |
Yao W.,Central Hospital of Cangzhou
Zhonghua yi xue za zhi | Year: 2014
OBJECTIVE: To investigate the effects of dexmedetomidine preconditioning attenuating remote lung injury of lower limb ischemia-reperfusion.METHODS: Sixty patients form Central Hospital of Cangzhou scheduled for lower limb operation with tourniquet from January 2014 to June 2014. Lumbar plexus combined with sciatic nerve block was performed guided by a nerve stimulator in both groups. All patients were randomly assigned to two groups, conventional general anesthesia group (R group, n = 30) and dexmedetomidine preconditioning group (Pre-Dex group, n = 30). In the group Pre-Dex, a dexmedetomidine intravenous infusion was started at a dose of 0.125 ml/kg (4 µg/ml) for 10 minutes before using tourniquet, whereas group R received an equivalent volume of normal saline. Blood samples were taken in femoral vein for 4 ml. Monocytes TLR4 expression and interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) level were determinated 15 minute before tourniquet inflation(T(1)), 15 minute (T(2)), 2 h(T(3)), 6 h(T(4))and 24 h(T(5)) after tourniquet release. Artery blood gas analysis, respiratory index and oxygenation index were measured by drawing off femoral artery for 2 ml.RESULTS: Compare with T(1), RI in group R was higher at T(4) and OI was lower at T(3-5) (P < 0.01), and there were no significant differences in group Pre-Dex at T(2)-T(5) about RI and OI (P > 0.05); IL-8,IL-6 level at T(3)-T(5) and TNF-α level at T(2)-T(5) in group R were significantly higher. IL-8,IL-6 level at T(3)-T(4) and TNF-α level at T(2)-T(4) in group Pre-Dex were higher. Monocytes TLR4 expression was higher in group R at T(3)-T(4) (P < 0.05). Compare with group R, RI in group Pre-Dex was lower and OI was higher at T(4) (P < 0.05); IL-8, IL-6 level at T(3)-T(5) and TNF-α level at T(2)-T(4) in group Pre-Dex was significantly lower (P < 0.05). Monocytes TLR4 expression was lower in group Pre-Dex at T(3)-T(5) (P < 0.05). IL-6, IL-8 level had positive correlation with TLR4 and RI ((r = 0.673, 0.647, 0.521, 0.457, P < 0.01 ), but had negative correlation with OI in group R (r = -0.613, -0.578, P < 0.01).CONCLUSION: Dexmedetomidine preconditioning attenuate remote lung injury of lower limb ischemia-reperfusion, and the mechanism may be related to down-regulation of monocytes TLR4 expression and degradation of IL-6, IL-8 and TNF-α level.
Yao J.,Central Hospital of Cangzhou |
Zheng K.,Hebei University |
Zhang X.,Central Hospital of Cangzhou
Molecular Medicine Reports | Year: 2015
Traumatic brain injury (TBI) is one of the leading causes of mortality and morbidity in adults and children worldwide. Recent studies have demonstrated that both apoptosis and autophagy participate in TBI-induced neuronal cell death and functional loss. The peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist rosiglitazone (RSG) is a well-known anti-inflammatory, which carries out its effects via the activation of PPAR-γ. Previous studies have suggested that RSG may exert neuroprotective effects in animal models of both chronic and acute brain injury; however, whether RSG is involved in autophagic neuronal death following TBI remains to be elucidated. The present study aimed to determine whether RSG carries out its neuroprotective properties via the attenuation of neuronal apoptosis and autophagy, following TBI in a rat model. Furthermore, the role of RSG was investigated with regards to the modulation of inflammation and glutamate excitotoxicity, and the impact of RSG on functional recovery following TBI was determined. The rats were subjected to controlled cortical impact injury, prior to being randomly divided into three groups: A sham-operated group, a TBI group, and an RSG treatment group. The RSG treatment group was intraperitoneally treated with 2 mg/kg RSG immediately after TBI. The results of the present study demonstrated that RSG treatment following TBI significantly reduced neuronal apoptosis and autophagy, and increased functional recovery. These effects were correlated with a decrease in the protein expression levels of tumor necrosis factor α and interleukin-6. However, no significant changes were observed in the protein expression levels of glutamate transporter-1 in the brain cortex. The results of the present study provide in vivo evidence that RSG may exert neuroprotective effects via the inhibition of neuronal apoptosis and autophagy following experimental TBI in rats, and the mechanism underlying these effects may be associated with the anti-inflammatory action of RSG. The present study offers a novel insight into the potential use of RSG as a neuroprotective agent for the treatment of cerebral injuries.
Yuan J.,Central Hospital of Cangzhou |
Dai G.,Central Hospital of Cangzhou |
Kong F.,Central Hospital of Cangzhou
International Journal of Clinical and Experimental Medicine | Year: 2016
The aim of this study was to compare the long-term and short-term outcomes of video-assisted thoracoscopic lobectomy (VATS) with those of open lobectomy for non-small-cell lung cancer (NSCLC) between well-matched patient groups. NSCLC patients underwent lobectomy with radical intent between January 2008 and January 2013, were divided into VATS and open groups. A one-to-one propensity case-matched analysis was used with covariates of baseline characteristics. Long-term and short-term outcomes were compared between the matched two groups. The two groups were well balanced by propensity score matching and 69 patients were matched. There were no significant differences in overall survival and disease-free survival between VATS and open groups. The median blood loss was significantly less with VATS, and the median postoperative hospital stay was significantly shorter for VATS. Complication rate was significantly less in VATS. VATS in selected patients with NSCLC showed similar long-term outcomes, associated with less blood loss, shorter hospital stay, and fewer postoperative complications. © 2016, E-Century Publishing Corporation. All rights reserved.
PubMed | Jilin University, Central Hospital of Cangzhou, National Science Foundation and Chinese People's Liberation Army
Type: | Journal: BioMed research international | Year: 2017
The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole body. This model has been used to assess the ageing process in a more precise way and may predict possible diseases better as compared with the chronological age (CA). The principal component analysis (PCA) is applied as one of the common and frequently used methods in the construction of the BA formula. Compared with other methods, PCA has its own study procedures and features. Herein we summarize the up-to-date knowledge about the BA formula construction and discuss the influential factors, so as to give an overview of BA estimate by PCA, including composition of samples, choices of test items, and selection of ageing biomarkers. We also discussed the advantages and disadvantages of PCA with reference to the construction mechanism, accuracy, and practicability of several common methods in the construction of the BA formula.
PubMed | Jilin University, Central Hospital of Cangzhou and Chinese People's Liberation Army
Type: | Journal: Forensic science international | Year: 2016
In forensic anthropology, facial soft tissue depth measurement is crucial for craniofacial reconstruction technology, which is based on the morphological features of human faces to rebuild appearances of decedents, helps forensic scientists to identify the nameless bone. We measured the facial tissue depth of 135 young subjects from northern China whereby revealing the relationship among tissue depth, sex and BMI as well as providing data for craniofacial reconstruction in forensic science. All the volunteers are healthy medical students including 64 males and 71 females. Ultrasound was used to measure 19 points across the face evenly distributed in 6 regions including the eye, nose, mouth, cheek, jaw and chin. Our results indicate that tissue thickness at 11 points of females and 11 points of males are related to BMI. A majority of points are thicker in females than those of males. Further comparisons with data of American and European population show an apparent diversity in both genders.