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Akbar S.,Regional Research Institute of Unani Medicine | Khan S.A.,Central Council for Research in Unani Medicine | Masood A.,University Of Kashmir | Iqbal M.,Regional Research Institute of Unani Medicine
African Journal of Traditional, Complementary and Alternative Medicines | Year: 2010

Some plants used in Unani system of medicine are toxic, even deadly poisonous. The drugs having such plants as their components are detoxified before they are dispensed to the patients. One such drug, capsule Hudar, has Strychnos nux-vomica L. (Azraqi) seeds as one of its components and is very effectively used to elevate blood pressure. Ancient manuscripts describe any methods of its detoxification. It has been found that the detoxification processes studied reduce the strychnine content, as determined either by using uv-vis spectrophotometer or HPLC, present in Strychnos nux vomica seeds which is responsible for Strychnos nux vomica toxicity. The decrease in strychnine amount was best when the seeds were immersed for detoxification in excess of water for 5 days, in milk for 2 days followed by their boiling in milk. Strychnine in small amounts has been reported to give subjective feeling of stimulation. Source

Alam M.,Regional Research Institute of Unani Medicine | Khan H.,Regional Research Institute of Unani Medicine | Samiullah L.,Regional Research Institute of Unani Medicine | Siddique K.M.,Central Council for Research in Unani Medicine
Journal of Applied Pharmaceutical Science | Year: 2012

Oleo-gum resin of Boswellia serrata Roxb ex Colebr. (Burseraceae) called Kundur in Unani system of Medicine is a prime ingredient in modern quality perfumes. The gum is popularly used in Indian Systems of Medicine (Unani, Ayurvedic & Sidha) for the last several centuriesin curing various aliment especially rheumatism and skin diseases. Kundur is one of the popular drugs for various ailments such as dysentery, dyspepsia, lung diseases, haemorrhoids, rheumatism, urinary disorders and corneal ulcer in Unani system of medicine for the last several years. It is also an ingredient in certain compound formulations viz: Majoon Kundur, Majoon Murawwah-ul-Arwah, Dawa-ul-Kibrit and HabbeSuzak of Unani medicine used in renal disorders. The studies carried out on Kundur (Boswellia serrata Roxb) reveal that Oleo-gum resin exhibits potent Anti-fungal, Anti-complementary, Juvenomimetic and Anti-carcinogenic properties. Investigations on Kundur also revealed its beneficial effects in Immunomodulation, Bronchial asthma, Polyarthritis, Hepatitis C-virus, Colitis and Crohn's disease. Phytochemistry andpharmacology on Kundur (Oleo-gum resin) of Boswellia serrata Roxb has been reviewed in this paper with the view to justify its recorded uses in Unani System of Medicine on scientific lines. Source

Kamal Y.,Hamdard University | Mohammed Musthaba S.,Hamdard University | Singh M.,Hamdard University | Parveen R.,Hamdard University | And 6 more authors.
Biomedical Chromatography | Year: 2012

An attempt has been made to develop and validate a simultaneous HPLC method for novel approach of drug release via oil-in-water (o/w) nanoemulsion formulation and Habb-e-Khardal Unani tablet containing piperine and guggul sterones E and Z as main ingredients. Nanoemulsion was prepared by titration method using sefsol-218 as an oily phase, cremophor-EL as a surfactant, transcutol as a co-surfactant and distilled water as an aqueous phase. The formulation was optimized on the basis of thermodynamic stability and dispersibilty test. The nanoformulation was evaluated for particle size, surface morphology, electrical conductivity and viscosity determination. The in vitro dissolution was carried out by dialysis bag method. Drugs were quantified using an HPLC method developed in-house with a C18 column as stationary phase and acetonitrile and water as mobile phase at λmax of 240nm. The optimized formulation showed higher drug release, lower droplet size and less viscosity as compared with the conventional Habb-e-Khardal Unani tablet. The present study illustrated the potential of nanoemulsion dosage form in improving biopharmaceutic performance of piperine and guggul sterone. The HPLC method was also found to be quite sufficient for the routine quality control of formulations containing piperine and guggul sterone E and Z as ingredients and also for in vitro drug release studies. © 2011 John Wiley & Sons, Ltd. Source

Sachdeva J.,All India Institute of Medical Sciences | Tanwar V.,All India Institute of Medical Sciences | Golechha M.,All India Institute of Medical Sciences | Siddiqui K.M.,Central Council for Research in Unani Medicine | And 4 more authors.
Experimental and Toxicologic Pathology | Year: 2012

Saffron (dried stigmas of Crocus sativus L.), a naturally derived plant product, has long been used as a traditional ancient medicine against various human diseases. The aim of the series of experiments was to systematically determine whether saffron exerts cardioprotection in isoproterenol-induced myocardial damage. Male Wistar rats (150-175. g) were divided into five groups: control, isoproterenol (ISO) and three saffron (200, 400 and 800. mg/kg) treatment groups. Aqueous extract of saffron or vehicle was administered orally to rats for four weeks. On days 28 and 29, the animals in ISO and saffron treatment groups were administered ISO (85. mg/kg, s.c.) at an interval of 24. h. On day 30, after recording hemodynamics and left ventricular functions, animals were sacrificed for biochemical, histopathological and electromicroscopical examinations. Isoproterenol challenged animals showed depressed hemodynamics and left ventricular functions as evident by decreased left ventricular rate of peak positive and negative pressure change and elevated left ventricular end-diastolic pressure. Structural and ultrastructural studies further confirmed the damage which was reconfirmed by increased thiobarbituric acid reactive substances (p<. 0.001) and decreased creatine kinase-MB and lactate dehydrogenase (p<. 0.001). In addition, significant reduction in superoxide dismutase and catalase (p<. 0.001) was observed in ISO group. Our results suggested that saffron at all the doses exerted significant cardioprotective effect by preserving hemodynamics and left ventricular functions, maintaining structural integrity and augmenting antioxidant status. Among the different doses used, saffron at 400. mg/kg dose exhibited maximum protective effects which could be due to maintenance of the redox status of the cell reinforcing its role as an antioxidant. © 2010 Elsevier GmbH. Source

Singh V.K.,Central Council for Research in Unani Medicine | Shweta,Ds College Affiliated To Dr Br Ambedar University
Contemporary Folk Medicines of India to Combat Human and Veterinary Diseases and Conditions | Year: 2012

Ethno-medicines have gained new dimensions in the present days through phyto-chemical research in India and abroad. Information on medicinal plants and folk drugs recorded during fieldwork is now being subjected to investigation in the search for new biodynamic compounds of therapeutic value. The curative properties of plants acquired by trial and error over centuries in "Human Laboratories" of tribals hold high esteem all over the globe. The present study is based on this rationale and provides first-hand information on some 1120 contemporary ethno-pharmacological prescriptions involving 444 taxa of medicinal plants collected and identified from certain rich tribal inhabited forest zones of the country between 1971-1997. © 2012 by Nova Science Publishers, Inc. All rights reserved. Source

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