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Sharma B.L.,Biyani Girls College | Singh D.,Biyani Girls College | Sharma S.K.,University of Rajasthan | Hashmi A.,Central Council for Research in Unani Medicine | And 2 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

During the present investigation, comparative study of primary metabolites i.e. Carbohyrates, Protein, Ascorbic acid, Starch, Lipids, Nucleic acids, Chlorophylls and Caretenoids, of genus Cassia were determined. The three species Cassia pumila, C. nodosa and C.renigera were undertaken for study and all the parts of respective plants were analyzed for their chemical composition. It was found that the higher level of starch, lipids, chlorophylls and nucleic acid was observed in Cassia nodosa leaves and phenols contents was higher in leaves of C. nodosa as well as in pods of C. pumila. The protein and lipid were found to be higher in pods of C. renigera.

Shenoy S.,Guru Nanak Dev University | Chaskar U.,Guru Nanak Dev University | Sandhu J.S.,Guru Nanak Dev University | Paadhi M.M.,Central Council for Research in Ayurvedic science
Journal of Ayurveda and Integrative Medicine | Year: 2012

Background: Cycling is an endurance sport relying mainly on aerobic capacity to provide fuel during long-duration cycling events. Athletes are constantly searching for new methods to improve this capacity through various nutritional and ergogenic aids. Purpose: The aim of the study was to find out the effect of Ashwagandha on the cardiorespiratory endurance capacity, that is, aerobic capacity of elite Indian cyclists. Materials and Methods: Forty elite (elite here refers to the participation of the athlete in at least state-level events) Indian cyclists were chosen randomly and were equally divided into experimental and placebo groups. The experimental group received 500 mg capsules of aqueous roots of Ashwagandha twice daily for eight weeks, whereas the placebo group received starch capsules. Outcome Measures: The baseline treadmill test for the cyclists were performed to measure their aerobic capacity in terms of maximal aerobic capacity (VO 2 max), metabolic equivalent, respiratory exchange ratio (RER), and total time for the athlete to reach his exhaustion stage. After eight weeks of supplementation, the treadmill test was again performed and results were obtained. Results: There was significant improvement in the experimental group in all parameters, whereas the placebo group did not show any change with respect to their baseline parameters. There was significant improvement in the experimental group in all parameters, namely, VO 2 max (t = 5.356; P < 0.001), METS (t = 4.483; P < 0.001), and time for exhaustion on treadmill (t = 4.813; P < 0.001) in comparison to the placebo group which did not show any change with respect to their baseline parameters. Conclusion: Ashwagandha improved the cardiorespiratory endurance of the elite athletes.

Kishore R.K.,National Ayurveda Dietetics Research Institute | Abhishekh H.A.,National Institute of Mental Health and Neuro Sciences | Udupa K.,Toronto Western Hospital | Thirthalli J.,National Institute of Mental Health and Neuro Sciences | And 4 more authors.
Asian Journal of Psychiatry | Year: 2014

Introduction: Ayurveda (Indian-complimentary and alternative medicine) is still most sought after in India and has promising potential in management of Vishada [major depressive disorder (MDD)]. But, systematic research is lacking. In this study we evaluated of influence of ayurvedic treatment (Panchakarma and Ayushman-15) on psychopathology, heart rate variability (HRV) and endocrinal parameters in patients with major depression. Methods: 81 drug naive patients diagnosed as Vishada by ayurvedic physician and MDD according to DSM IV-TR were given ayurvedic Virechana module (therapeutic purgation) and were randomized into two groups. Patients in group A (n= 41) received Ayushman-15A while group B (n= 40) received Ayushman-15B for two months and Shirodhara (forehead-oil pouring therapy). Patients were assessed with Hamilton Depression Rating Scale (HDRS), Montgomery Asberg Depression Rating Scale (MADRS), Heart Rate Variability (HRV). Cortisol and adrenocorticotropic hormone (ACTH) were estimated at baseline and after ayurvedic therapy. HRV and endocrinal parameters were compared with age and gender matched healthy volunteers. Results: HRV parameters showed significant sympathetic dominance in patients compared to healthy volunteers. Two months of ayurvedic treatment significantly decreased psychopathology, showed increase in vagal tone, decrease in sympathetic tone and reduced cortisol levels. However, there was no significant difference between groups receiving Ayushman A and B. Conclusion: This study provides evidence for antidepressant, cardiac (HRV) and beneficial neuroendocrine modulatory influence of Ayurveda therapy in patients of Vishada (MDD). Further studies are needed to confirm these findings. Greater insight into the neurobiology behind this therapy might provide valuable information about newer drug target. © 2014 Elsevier B.V.

Singh V.,Dr. B.R. Ambedkar University | Rana R.K.,Central Council for Research in Ayurvedic science | Singhal R.,Central Council for Research in Ayurvedic science
Journal of Ayurveda and Integrative Medicine | Year: 2013

Statistics is an integral part of Clinical Trials. Elements of statistics span Clinical Trial design, data monitoring, analyses and reporting. A solid understanding of statistical concepts by clinicians improves the comprehension and the resulting quality of Clinical Trials. In biomedical research it has been seen that researcher frequently use t-test and ANOVA to compare means between the groups of interest irrespective of the nature of the data. In Clinical Trials we record the data on the patients more than two times. In such a situation using the standard ANOVA procedures is not appropriate as it does not consider dependencies between observations within subjects in the analysis. To deal with such types of study data Repeated Measure ANOVA should be used. In this article the application of One-way Repeated Measure ANOVA has been demonstrated by using the software SPSS (Statistical Package for Social Sciences) Version 15.0 on the data collected at four time points 0 day, 15 th day, 30 th day, and 45 th day of multicentre clinical trial conducted on Pandu Roga (~Iron Deficiency Anemia) with an Ayurvedic formulation Dhatrilauha.

Mishra D.,Central Council for Research in Ayurvedic science | Singh R.K.,Veer Kunwar Singh University | Srivastava R.K.,Narendra Deva University of Agriculture and Technology Crop Research Station | Dubey S.R.,Veer Kunwar Singh University
Medicinal Plants | Year: 2013

The present study is an effort to save the precious heritage of local folks and traditional healers of Sitapur district in Uttar Pradesh regarding uses of herbal remedies against gynaecological disorders. The indigenous knowledge was gathered through interactions with rural population through informal interviews with the informants in their local language. This is the first-hand information on 45 ethno-medicinal plant species belonging to 30 families used to cure gynaecological disorders by ethnic populace. The largest numbers of 25% plant species were used to treat leucorrhoea, 24% plant species for menstrual ailments, 17% plant species for gonorrhoea, 9% plant species for both delivery and abortion related issues and 8% used for lactation and as contraceptives.

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