Center Tower

Baltimore, MD, United States

Center Tower

Baltimore, MD, United States

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Weiss C.O.,Center Tower | Boyd C.M.,Center Tower | Leff B.,Center Tower
Aging Clinical and Experimental Research | Year: 2012

Background and aims: Potential treatment effect modifiers (TEMs) are specific diseases or conditions with a well-described mechanism for treatment effect modification. The prevalence of TEMs in older adults with type 2 diabetes mellitus (DM) is unknown. Objectives were to 1) determine the prevalence of pre-specified potential TEMs; 2) demonstrate the potential impact of TEMs in the older adult population using a simulated trial; 3) identify TEM combinations associated with number of hospitalizations to test construct validity. Methods: Data are from the nationally-representative United States National Health and Examination Survey, 1999-2004: 8646 Civilian, non-institutionalized adults aged 45-64 or 65+ years, including 1443 with DM. TEMs were anemia, congestive heart failure, liver inflammation, polypharmacy, renal insufficiency, cognitive impairment, dizziness, frequent mental distress, mobility difficulty, and visual impairment. A trial was simulated to examine prevalence of potential TEM impact. The cross-sectional association between TEM patterns and number of hospitalizations was estimated to assess construct validity. Results: The prevalence of TEMs was substantial such that 19.0% (95% CI 14.8-23.2) of middle-aged adults and 38.0% (95% CI 33.4-42.5) of older adults had any two. A simulated trial with modest levels of interaction suggested the prevalence of TEMs could nullify treatment benefit in 3.9-27.2% of older adults with DM. Compared to having DM alone, hospitalization rate was increased by several combinations of TEMs with substantial prevalence. Conclusions: We provide national benchmarks that can be used to evaluate TEM prevalence reported by clinical trials of DM, and correspondingly their external validity to older adults. ©2012, Editrice Kurtis.


Bartlett S.J.,McGill University | Bartlett S.J.,Center Tower
Rheumatic Disease Clinics of North America | Year: 2011

This article reviews the existing literature on using yoga for arthritis. It includes peer-reviewed research from clinical trials (published from 1980 to 2010) that used yoga as an intervention for arthritis and reported quantitative findings. Eleven studies were identified, including 4 randomized controlled trials (RCTs) and 4 non-RCTs. All trials were small and control groups varied. No adverse events were reported, and attrition was comparable or better than that typical for exercise interventions. Evidence was strongest for reduced disease symptoms (tender/swollen joints, pain) and disability and for improved self-efficacy and mental health. Interventions, research methods, and disease diagnoses were heterogeneous. © 2011 Elsevier Inc.


PubMed | Center Tower
Type: Journal Article | Journal: Public health nutrition | Year: 2016

To examine the growth of infants and toddlers in a population that is both under-represented in the literature and at high risk for childhood obesity.Weight and height measurements were extracted from all visits for a sample of 0-4-year-old, low-income, Latino and non-Latino patients of an urban, academic general paediatric practice. Early growth was characterized as change in weight-for-length Z-score (WLZ) from birth to 3 years. The outcome of interest was BMI Z-score (BMIZ) at age 3 years. Mixed-effects models and multivariate linear regression were used to analyse the association between infant growth and early childhood obesity.Baltimore, MD, USA.Latino (n 210) and non-Latino (n 253) children, born in 2003-2004.An increase in WLZ from birth to 2 years was observed for this cohort as well as a high incidence of overweight and obesity. WLZ at birth and change in WLZ from birth to 2 years were both significantly and positively associated with increases in BMIZ at 3 years of age. The effect of the change in WLZ was twofold higher than the effect of WLZ at birth.An increase in WLZ during the first 2 years of life increased the risk of early childhood obesity. Latino children had a higher incidence of early childhood obesity than non-Latino children in this low-income sample.


Louie G.H.,Center Tower | Louie G.H.,U.S. National Institutes of Health | Tektonidou M.G.,National and Kapodistrian University of Athens | Caban-Martinez A.J.,University of Miami | Ward M.M.,U.S. National Institutes of Health
Arthritis Care and Research | Year: 2011

Objective. To examine the prevalence of sleep disturbances in adults with arthritis in a nationally representative sample, mediators of sleep difficulties, and subgroups of individuals with arthritis at greatest risk. Methods. Using data on US adults ages ≥18 years participating in the 2007 National Health Interview Survey, we computed the prevalence of 3 measures of sleep disturbance (insomnia, excessive daytime sleepiness, and sleep duration <6 hours) among persons with arthritis. We used logistic regression analysis to examine if the association of arthritis and sleep disturbances was independent of sociodemographic characteristics and comorbidities, and to identify potential mediators. We used classification trees to identify subgroups at higher risk. Results. The adjusted prevalence of insomnia was higher among adults with arthritis than those without arthritis (23.1% versus 16.4%; P < 0.0001), but was similar to those with other chronic diseases. Adults with arthritis were more likely than those without arthritis to report insomnia (unadjusted odds ratio 2.92, 95% confidence interval 2.68-3.17), but adjustment for sociodemographic characteristics and comorbidities attenuated this association. Joint pain and limitation due to pain mediated the association between arthritis and insomnia. Among adults with arthritis, those with depression and anxiety were at highest risk for sleep disturbance. Results for excessive daytime sleepiness and sleep duration <6 hours were similar. Conclusion. Sleep disturbance affects up to 10.2 million US adults with arthritis, and is mediated by joint pain and limitation due to pain. Among individuals with arthritis, those with depression and anxiety are at greatest risk. © 2011, American College of Rheumatology.


News Article | November 14, 2016
Site: www.businesswire.com

HONG KONG--(BUSINESS WIRE)--NTT Communications Corporation (NTT Com), the ICT solutions and international communications business within the NTT Group (NYSE: NTT) announced today it has received three prestigious awards at DatacenterDynamics Asia Pacific Awards 2016. NTT Communications Hong Kong Financial Data Center Tower 2 (FDC2) was named the winner of “Service Provider Data Center” award, and “Critical Environment Future Thinking” category in collaboration with Emerson Network Power. Netmagic, an NTT Communications Group Company, was also awarded the “Data Center Critical Environment Team of the Year Award”, which recognizes the achievements of the construction team behind DC5 Mumbai. The DatacenterDynamics Awards presents the best examples of data center innovation in design, build and management that addresses the key challenges in the Asia Pacific, which is one of the most diverse and substantially growing regions in the world. Among 80 entries from 12 Asian countries/regions including Australia, Indonesia, China, Singapore, Japan, Hong Kong and others, NTT Communications Group led the pack by winning three out of the eight highly-competitive award categories. "We're extremely proud of NTT Communications being recognized as the leading data center service provider in Asia Pacific,” said Taylor Man, Chief Technology Officer of NTT Com Asia. “The awards not only show that our future-proof data center design is widely recognized by industry heavyweights, but also confirms the values we have strived to create for our customers: Technology Innovations, Performance Quality and Service Excellence”. NTT Communications’ Nexcenter™ offers globally standardized data center service backed by quality, flexibility, and cost-efficiency in over 140 locations worldwide. In Hong Kong the company operates two data centers, the Hong Kong Financial Data Center (with two towers, FDC1 and FDC2) and the Tai Po Data Center. NTT Communications’ data centers in Hong Kong has integrated high density energy efficient design and innovative technologies, with the vision to enhance customers’ business performance. NTT Com will continue to enhance its global seamless ICT solutions as it expands data center business worldwide. NTT Communications provides consultancy, architecture, security and cloud services to optimise the information and communications technology (ICT) environments of enterprises. These offerings are backed by the company’s worldwide infrastructure, including leading global tier-1 IP network, Arcstar Universal One™ VPN network reaching 196 countries/regions, and 140 secure data centres worldwide. NTT Communications’ solutions leverage the global resources of NTT Group companies including Dimension Data, NTT DOCOMO and NTT DATA. Please visit www.ntt.com.hk | www.hknet.com | www.facebook.com/nttca | http://www.linkedin.com/company/ntt-com-asia-limited for further information.


HONG KONG--(BUSINESS WIRE)--NTT Communications Corporation (NTT Com), the ICT solutions and international communications business within NTT Group (NYSE: NTT), today announced that its Hong Kong-based Financial Data Center Tower 2 (FDC2) received the Uptime Institute Management & Operations (M&O) Stamp of Approval. NTT Com is the first data center service provider in Hong Kong to earn this recognition, underscoring its commitment to operational excellence and efficiency as part of its Nexcenter brand promise for all of its global data centers. The Uptime Institute M&O Stamp of Approval involves a set of rigorous risk analysis and industry-specific evaluation criteria that recognize data centers for their management and operations capabilities, independent of their infrastructure. These include areas such as staffing and organization, training, maintenance, planning, management, etc. The thorough review examines the accountability, visibility and commitment across the company’s leadership and service operation teams, giving an ultimate assurance that the best practice is in place. “We are honored to be the first service provider in Hong Kong to receive this award. The independent validation proves that our continual operational improvements to minimize downtime and improve reliability through 100% uptime with guaranteed SLAs at FDC2 are globally recognized. It is also a testament to our Nexcenter brand promise for all our data centers in Hong Kong and worldwide," said Taylor Man, Chief Technology Officer, NTT Com Asia. The Uptime Institute M&O Stamp of Approval builds on NTT Communications’ growing list of professional certifications and award portfolios for its Hong Kong data centers. These include compliance with the Payment Card Industry Data Security Standard (PCI DSS), a globally-recognized security standard for handing branded credit card transactions, and information storage and compliance with ISAE 3402 that meets financial services regulatory requirements for Threat and Vulnerability Risk Assessment (TVRA). “Together, they assure our customers that NTT Communications is investing in their long-term success. Our customers, especially financial service institutions, will benefit from our commitment in operational excellence, as we continue to innovate ourselves in an increasingly competitive and regulated environment,” Man added. NTT Communications provides consultancy, architecture, security and cloud services to optimise the information and communications technology (ICT) environments of enterprises. These offerings are backed by the company’s worldwide infrastructure, including leading global tier-1 IP network, Arcstar Universal One™ VPN network reaching 196 countries/regions, and 140 secure data centres worldwide. NTT Communications’ solutions leverage the global resources of NTT Group companies including Dimension Data, NTT DOCOMO and NTT DATA. Please visit www.ntt.com.hk | www.hknet.com | www.facebook.com/nttca | http://www.linkedin.com/company/ntt-com-asia-limited for further information. Uptime Institute is an unbiased advisory organization focused on improving the performance, efficiency, and reliability of business critical infrastructure through innovation, collaboration, and independent certifications. Uptime Institute serves all stakeholders responsible for IT service availability through industry leading standards, education, peer-to-peer networking, consulting, and award programs delivered to enterprise organizations and third-party operators, manufacturers, and providers. Uptime Institute is recognized globally for the creation and administration of the Tier Standards & Certifications for Data Center Design, Construction, and Operational Sustainability along with its Management & Operations reviews, FORCSS® methodology, and Efficient IT Stamp of Approval. Uptime Institute – The Global Data Center Authority®, a division of The 451 Group, has office locations in the U.S., Mexico, Costa Rica, Brazil, U.K., Spain, U.A.E., Russia, Taiwan, Singapore, and Malaysia. Please Visit www.uptimeinstitute.com for further information.


Chung H.S.,Johns Hopkins University | Wang S.-B.,Johns Hopkins University | Venkatraman V.,Johns Hopkins University | Murray C.I.,Johns Hopkins University | And 2 more authors.
Circulation Research | Year: 2013

In the cardiovascular system, changes in oxidative balance can affect many aspects of cellular physiology through redox-signaling. Depending on the magnitude, fluctuations in the cell's production of reactive oxygen and nitrogen species can regulate normal metabolic processes, activate protective mechanisms, or be cytotoxic. Reactive oxygen and nitrogen species can have many effects including the posttranslational modification of proteins at critical cysteine thiols. A subset can act as redox-switches, which elicit functional effects in response to changes in oxidative state. Although the general concepts of redox-signaling have been established, the identity and function of many regulatory switches remains unclear. Characterizing the effects of individual modifications is the key to understand how the cell interprets oxidative signals under physiological and pathological conditions. Here, we review the various cysteine oxidative posttranslational modifications and their ability to function as redox-switches that regulate the cell's response to oxidative stimuli. In addition, we discuss how these modifications have the potential to influence other posttranslational modifications' signaling pathways though cross-talk. Finally, we review the increasing number of tools being developed to identify and quantify the various cysteine oxidative posttranslational modifications and how this will advance our understanding of redox-regulation. © 2012 American Heart Association, Inc.


Mecoli C.A.,Center Tower | Delev N.G.,Center Tower | Bingham C.O.,Center Tower
Clinical Rheumatology | Year: 2016

The change in transaminase levels over a single week during therapy with methotrexate (MTX) has not been investigated or reported to date. In clinical practice, it is common to observe abnormal transaminase levels upon routine blood work for toxicity monitoring. Many have suggested that such lab abnormalities can sometimes be attributed to sampling blood for toxicity monitoring proximately following MTX dosing. The aim of our study was to evaluate changes in transaminase levels (AST/ALT) over 1 week after MTX administration in rheumatoid arthritis (RA) patients. In this small proof of concept study, we evaluated 13 patients with RA taking stable doses of methotrexate and background medications (e.g., NSAIDs and prednisone), but no other disease-modifying anti-rheumatic drugs (DMARDs). All patients were on a stable dose of folic acid. Patients received their usual doses of MTX administered at a specified time, and then sequential blood samples were obtained over the course of 7 days. Peripheral blood was obtained at each time point to measure serum transaminases. We did not observe any significant change in sequential transaminases over 1 week in relationship to MTX administration. It is possible that MTX therapy alone does not lead to significant weekly transaminase variations, contrary to our clinical expectations. The addition of other medications (i.e., NSAIDs) to stable MTX regimen may result in transaminase abnormalities. © 2016 International League of Associations for Rheumatology (ILAR)


PubMed | Center Tower
Type: Journal Article | Journal: Clinical rheumatology | Year: 2016

The change in transaminase levels over a single week during therapy with methotrexate (MTX) has not been investigated or reported to date. In clinical practice, it is common to observe abnormal transaminase levels upon routine blood work for toxicity monitoring. Many have suggested that such lab abnormalities can sometimes be attributed to sampling blood for toxicity monitoring proximately following MTX dosing. The aim of our study was to evaluate changes in transaminase levels (AST/ALT) over 1week after MTX administration in rheumatoid arthritis (RA) patients. In this small proof of concept study, we evaluated 13 patients with RA taking stable doses of methotrexate and background medications (e.g., NSAIDs and prednisone), but no other disease-modifying anti-rheumatic drugs (DMARDs). All patients were on a stable dose of folic acid. Patients received their usual doses of MTX administered at a specified time, and then sequential blood samples were obtained over the course of 7days. Peripheral blood was obtained at each time point to measure serum transaminases. We did not observe any significant change in sequential transaminases over 1week in relationship to MTX administration. It is possible that MTX therapy alone does not lead to significant weekly transaminase variations, contrary to our clinical expectations. The addition of other medications (i.e., NSAIDs) to stable MTX regimen may result in transaminase abnormalities.


News Article | February 15, 2017
Site: www.businesswire.com

香港--(BUSINESS WIRE)--NTT Communications today announced that its Hong Kong-based Financial Data Center Tower 2 (FDC2) received the Uptime Institute Management & Operations (M&O) Stamp of Approval.

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