Marc B.,Center Hospitalier Of Compiegne |
Marc B.,Center Technique Of La Securite Interieure |
Fuche C.,Center Hospitalier Of Compiegne |
Fuche C.,Center Technique Of La Securite Interieure |
And 6 more authors.
Actualite Chimique | Year: 2010
Mainly since 1990's the role of drug in driver impairment and motor vehicle crashes has been established. A study in 2007 in Oise department allowed to estimate delta(9)-tetrahydrocannabinol (THC) prevalence in 99 drivers suspected of driving under the influence of drug (DUID). Among 84 records analyzed (GC/MS), 76 (90.4%) were found positive for active THC components. Median blood level by GC/MS was 6.29 ng/mL for THC and 2.48 ng/mL for 11-OH THC. A second study analyzed by GC/MS 160 blood samples collected in 2007 and 2008 from drivers suspected of DUID with cannabidiol dosage. When median blood level was 4.64 ng/mL for THC and 2.46 ng/mL for 11-OH-THC, median cannabidiol blood level was 3.33 ng/mL. Discrepancies between high THC and cannabidiol blood concentrations indicate « skunk » use. Cannabidiol dosage helps to understand clinical effects observed in cannabis users and assessed by forensic consequences currently observed.