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Chebat A.,Mohammed V University | Chebat A.,Center National Of Pharmacovigilance | Skalli S.,Center National Of Pharmacovigilance | Errihani H.,Institute National dOncologie INO | And 5 more authors.
Phytotherapie | Year: 2014

In order to assess the prevalence of adverse effects (AEs) associated with the use of medicinal plants (MP), we conducted a survey of 1 234 patients during four months at the National Institute of Oncology (INO) in Rabat and more precisely within the inpatient and day hospital of INO. This survey is based on the use of a 10-item questionnaire used to gather the necessary information about the patient and the MPs used. Our researches on the 1 234 patients surveyed showed that 35% use MP. Among them, 98.5% did not disclose the information to their physicians dealing with a sex ratio of 0.6. Of all patients surveyed having used MP, 16% experienced adverse effects more or less serious (68% of women). They cite the tubule-interstitial nephritis, which represents the most common side effect (15.7%) followed by liver damage (12.9%), diarrhea (5.7%), vomiting, constipation and rectal bleeding with a frequency of 4.3% each. Although some plants are criminalized such as Nigella sativa L. and Aristolochia longa L. The use of MP by Moroccan patients is an alternative. These plants can be used before, after or during medical treatments which contributes to the occurrence of AEs. © 2013 Springer-Verlag France. Mots clés: Plante médicinaleOncologieEffet indésirableMaroc.

Salouege I.,Center National Of Pharmacovigilance | Ali R.,Center National Of Pharmacovigilance | Said D.,Center National Of Pharmacovigilance | Elkadri N.,Service de Medecine Nucleaire | And 3 more authors.
Journal of Cancer Research and Therapeutics | Year: 2014

Objectives: This work is aimed on the study of doxorubicin cardiotoxicity and hepatotoxicity in rats and the evaluation of protective effect of trimetazidine administrated concomitantly with doxorubicin for 3 days. Materials and Methods: Male Wistar rats used were subjected to different types of treatment (3 days); A: Control, B: Doxorubicin treatment and C: Trimetazidine and doxorubicin treatment. After sacrifice, tissular distribution of doxorubicin, cardiac scintigraphy, histological examination of the myocardium, and evaluation of liver function were assessed. Results: Obtained results show that doxorubicin has a high affinity to tissues especially the heart. It causes hepatotoxicity and cardiotoxicity marked by a significant increase of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) levels and drop of the left ventricular ejection fraction (EF LV ) by scintigraphy. Histological examination showed general alteration of myocardium structure. Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin. Conclusion: We have evaluated the protective effect of trimetazidine on an animal model of doxorubicin-induced cardiotoxicity and hepatotoxicity. The evaluation of these effects were assessed by several means; tissular distribution of doxorubicin, histological examination, assessment of liver function, and EF LV by scintigraphy that characterizes the originality of this study.

Ben Said D.,Center National Of Pharmacovigilance | Ben Ali R.,Center National Of Pharmacovigilance | Ferchichi H.,Center National Of Pharmacovigilance | Salouage I.,Center National Of Pharmacovigilance | And 8 more authors.
Hepatology International | Year: 2011

Purpose: In this study, we developed an ex vivo functional assay to assess liver metabolic capacity adapted from the lidocaïne test in rats. Methods: Animals used were subjected to different models of liver injury: hypothermic ischemia (H/I, n = 8), ischemia-reperfusion (I/R, n = 8) and CCl4 induced liver cirrhosis (n = 11), and compared with sham operated rats (n = 5). Livers were then extracted and a fragment of whole tissue was incubated with lidocaïne for 15, 30, 60, 120, 240, 360, and 720 min at which both lidocaïne and its major metabolite monoethylglycinexylidide (MEGX) were measured by high performance liquid chromatography (HPLC). A histological study and biochemical assays (transaminase levels) were also performed to further evaluate and confirm our data. Results: Pharmacokinetic profile of lidocaïne metabolism in sham-operated animals revealed that the maximum concentration of MEGX is achieved at 120 min. Both lidocaïne metabolism and MEGX formation levels were significantly altered in all three models of hepatic injury. The extent of hepatic damage was confirmed by increased levels of transaminase levels and alteration of hepatocyte's structure with areas of necrosis. Conclusion: Our method provides reliable and reproducible results using only a small portion of liver which allows for a fast and easy assessment of liver metabolic capacity. Moreover, our method presents an alternative to the in vivo technique and seems more feasible in a clinical setting. © 2011 Asian Pacific Association for the Study of the Liver.

Fakhfakh R.,National Health Research Institute | Fakhfakh R.,National Institute of Public Health | Jellouli M.,National Health Research Institute | Klouz A.,Center National Of Pharmacovigilance | And 4 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2011

Objective. The validity of self-reported smoking in population surveys remains an important question yet to be answered. This has been of particular concern in a situation where there is a strong social pressure against pregnant and postpartum women. An associated question is what would be the value of measuring urinary cotinine concentrations in such surveys to obtain validated smoking data. Methods. Cross-sectional analysis of data on self-reported smoking and urinary cotinine among a sample of 398 pregnant women and recently pregnant, mothers of infants under the age of 2 months, who came to the Family Planning Clinic in Tunis urban area for either prenatal or newborn care. We used quantitative colorimetric urine test based on the könig reaction, in which pink-red chromophores formed from nicotine and its metabolites condensation with barbituric acid were extracted into acetate buffer. Results. The smoking prevalence among Tunisian pregnant women or mothers of newborn infants was 4%. The validity of self-reported daily smoking was relatively low. Among women reporting no smoking at the interview 16% misreported active smoking. According to urinary cotinine values, the smoking prevalence was 18.8%. Conclusions. These results substantiate the unreliability of self-report on smoking status among women in prenatal and postnatal period and have implications in clinical and education practice. © 2011 Informa UK, Ltd.

Kastalli S.,Center National Of Pharmacovigilance | El Aidli S.,Center National Of Pharmacovigilance | Zaiem A.,Center National Of Pharmacovigilance | Ben Abdallah H.,Military Hospital | Daghfous R.,Center National Of Pharmacovigilance
Fundamental and Clinical Pharmacology | Year: 2010

Clopidogrel, an adenosine diphosphate receptor blocker, is widely used as an adjunctive antiplatelet therapy in acute coronary syndrome and percutaneous coronary stenting. It appears to be a safe drug with few occurrences of liver side-effects that usually resolved after drug withdrawal. We report a serious liver injury with fatal outcome in a 63-year-old man developed 19 days after starting clopidogrel for percutaneous coronary stenting. © 2009 Société Française de Pharmacologie et de Thérapeutique.

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