Center National des science et Technologies Nucleaires

Ariana, Tunisia

Center National des science et Technologies Nucleaires

Ariana, Tunisia

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Dallagi T.,Center National des science et Technologies Nucleaires | Dallagi T.,École Nationale Supérieure de Chimie de Paris | Saidi M.,Center National des science et Technologies Nucleaires | Vessieres A.,École Nationale Supérieure de Chimie de Paris | And 3 more authors.
Journal of Organometallic Chemistry | Year: 2013

1-(p-(ferrocenylcarbonylamino-phenyl)-1,2-di(p-hydroxyphenyl)-but-1-ene,1, and 1-(p-(cymantrenylcarbonylamino-phenyl)-1,2-di(p-hydroxyphenyl)-but-1-ene, 2, were synthesized. Both compounds exhibit a significant antiproliferative effect against hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cells (IC50 = 4.5 and 9.4 μM for 1 and 2 respectively on MDA-MB-231 and around 1 μM for 1 and 2 on MCF-7 cells). Interestingly, 2 is the first cymantrenyl complex in this triaryl butene series to show such a high cytotoxic effect. A metal exchange reaction between 1 and 99mTcO 4 - was used for the synthesis of 1-(p- (tricarbonylcyclopentadienyl-[99mTc]-technetium carboxy-amino-phenyl) -1,2-di(p-hydroxyphenyl)-but-1-ene, 3. 99mTc-3 was obtained in 70-75% yield. The in vivo biodistribution of purified 99mTc-3 was undertaken on mature female Wistar rats. The uptake by organs follows the order: liver > lung > kidney > heart > spleen > ovaries > bone > muscle > uterus. The ovaries/muscle ratio was 3.89 while that of uterus/muscle ratio was 0.99. Uptake in ovaries was abolished by co-administration of 17β-estradiol while that of most organs devoided of estrogen receptors remained unchanged. © 2012 Elsevier B.V. All rights reserved.


Chargui Y.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Chetouani L.,University of Mentouri Constantine | Trabelsi A.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Center National des science et Technologies Nucleaires
Communications in Theoretical Physics | Year: 2010

Specific modifications of the usual canonical commutation relations between position and momentum operators have been proposed in the literature in order to implement the idea of the existence of a minimal observable length. Here, we study a consequence of this proposal in relativistic quantum mechanics by solving in the momentum space representation the Klein-Gordon oscillator in arbitrary dimensions. The exact bound states spectrum and the corresponding momentum space wave function are obtained. Following Chang et al. (Phys. Rev. D 65 (2002) 125027), we discuss constraint that can be placed on the minimal length by measuring the energy levels of an electron in a penning trap. © 2010 Chinese Physical Society and IOP Publishing Ltd.


Chargui Y.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Center National des science et Technologies Nucleaires | Chetouani L.,University of Mentouri Constantine
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

We present an exact analytical treatment of the semi-relativistic spinless Salpeter equation with a one-dimensional Coulomb interaction in the context of quantum mechanics with modified Heisenberg algebra implying the existence of a minimal length. The problem is tackled in the momentum space representation. The bound-state energy equation and the corresponding wave functions are exactly obtained. © 2010 Elsevier B.V. All rights reserved.


Chargui Y.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Center National des science et Technologies Nucleaires | Chetouani L.,University of Mentouri Constantine
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

We solve the DKP equation with a pseudoscalar linear plus Coulomb-like potential in a two-dimensional space-time. The problem is mapped into an effective quadratic plus inversely quadratic potential in a Sturm-Liouville type equation. The exact energy spectrum and the corresponding normalized eigenstates are obtained. The particular case of the DKP oscillator is also discussed. © 2010 Elsevier B.V. All rights reserved.


Hrichi H.,University of Carthage | Hrichi H.,Center National des science et Technologies Nucleaires | Baccouche S.,Center National des science et Technologies Nucleaires | Belgaied J.-E.,University of Carthage
Journal of Environmental Radioactivity | Year: 2013

The health impacts associated with uncontrolled release of TENORM in products and wastes released in the petroleum industry are of great concern. In this study, evaluation of TENORM in the Tunisian petroleum products and wastes is presented. Fourteen products samples, twelve waste samples and three samples from the surrounding environment were collected from the Tunisian Refinery STIR site and from two onshore production oilfields. The activity concentrations of 232Th, 226Ra and 40K for all samples were determined using gamma-ray spectrometry with High Purity Germanium (HPGe) detector. The activity concentrations of 224Ra were calculated only for scale samples. The radium equivalent activity, external and internal hazard indices, absorbed doses rates in air and annual effective dose were also estimated. It was noticed that maximum value of Raeq activity was found to be 398 Bq/kg in scale (w8) collected from an onshore production oilfield which exceeds the maximum Raeq value of 370 Bq/kg recommended for safe use. All hazard indices indicated that scale samples (w6, w7, w8 and w11) could be a significant waste problem especially sample (w8). In this study, the radium isotopic data were used to provide an estimate of scale samples ages by the use of the 224Ra/228Ra activity ratio dating method. Ages of collected scales were found to be in the range 0.91-2.4 years. In this work, radioactivity (NORM contamination) in samples collected from the refinery STIR are showed to be insignificant if compared to those from onshore oilfield production sites. © 2012 Elsevier Ltd.


Chargui Y.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Unite de Recherche de Physique Nucleaire et des Hautes Energies | Trabelsi A.,Center National des science et Technologies Nucleaires | Chetouani L.,University of Mentouri Constantine
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

We present an exact solution of the (1 + 1)-dimensional Dirac equation with vector and scalar linear potentials in the context of modified quantum mechanics characterized by the presence of a non-zero minimum uncertainty in position. The bound-states energy spectrum and the corresponding momentum space wavefunctions are exactly obtained. Our findings are compared with approximated results existing in the literature. © 2009 Elsevier B.V. All rights reserved.


Pruvost L.,French National Center for Scientific Research | Jelassi H.,Center National des science et Technologies Nucleaires
Journal of Physics B: Atomic, Molecular and Optical Physics | Year: 2010

In this paper we report on the analysis of the (6s1/2 + 6p 1/2)0-g weakly bound levels of Cs2 detected by photoassociation spectroscopy. We compare three methods of analysis: the use of the LeRoy-Bernstein formula, the use of the improved LeRoy-Bernstein formula and the use of the vibrational quantum defect. We show that the vibrational quantum defect method is more sensitive than the other methods and allows us to detect two deeply bound levels of the (6s1/2 + 6p 3/2)0-g potential, which are not detected by other methods. The binding energies of the levels are found to be 565.49 and 591.43 cm-1 below the (6s1/2+6p3/2) dissociation limit. © 2010 IOP Publishing Ltd.


Ben Abdelouahed H.,Center National des science et Technologies Nucleaires | Reguigui N.,Center National des science et Technologies Nucleaires | Abbes N.E.,Groupe Chimique Tunisien GCT
Applied Radiation and Isotopes | Year: 2016

To determine residence time distribution (RTD) in the phosphate treatment reactor we apply radiotracer method. However this method becomes effective and profitable only if the radiotracer is the suitable one. The problem to resolve in our study is "which phase of the phosphate slurry our injected radiotracer is following?". For that we add radiotracer to the phosphate slurry and we proceed to phase separation using a filtration system. We follow simultaneously -using appropriate detectors- the behavior and the quantity of the radiotracer in both phases during the separation stage. The same experiment is applied twice using successively 99mTc and 131I radiotracers. The comparative study proves that 131I is more suitable than 99mTc for solid phase labeling of phosphate slurry. © 2016 Elsevier Ltd.


Dallagi T.,Center National des science et Technologies Nucleaires | Top S.,École Nationale Supérieure de Chimie de Paris | Masi S.,École Nationale Supérieure de Chimie de Paris | Jaouen G.,École Nationale Supérieure de Chimie de Paris | Saidi M.,Center National des science et Technologies Nucleaires
Metallomics | Year: 2010

In our efforts to develop a novel class of SPECT imaging agents based on nonsteroidal androgen receptor (AR) antagonists, we have synthesized N-cyclopentadienyltricarbonyltechnetium-N-[4-nitro-3-trifluoromethyl-phenyl] carboxamide (NF99mTc), an analog of the AR antagonist ligand flutamide. NF99mTc was obtained in 82% yield from the reaction of N-[4-nitro-3-trifluoromethyl-phenyl]-ferrocenecarboxamide (NFFe) with fac-[ 99mTc(H2O)3(CO)3]+ in DMF-water at pH 1 and at 150 °C for 1 h. The corresponding Re analog was also prepared. In vitro assays demonstrated high stability of NF99mTc under physiological conditions, buffer and blood. The tissue biodistribution in mature male Wistar rats showed a significant selective uptake by prostate but this uptake was not blocked by an excess of testosterone acetate. A higher uptake by lung tissues was observed. © 2010 The Royal Society of Chemistry.


PubMed | Groupe Chimique Tunisien GCT and Center National des science et Technologies Nucleaires
Type: | Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | Year: 2016

To determine residence time distribution (RTD) in the phosphate treatment reactor we apply radiotracer method. However this method becomes effective and profitable only if the radiotracer is the suitable one. The problem to resolve in our study is which phase of the phosphate slurry our injected radiotracer is following?. For that we add radiotracer to the phosphate slurry and we proceed to phase separation using a filtration system. We follow simultaneously -using appropriate detectors- the behavior and the quantity of the radiotracer in both phases during the separation stage. The same experiment is applied twice using successively (99m)Tc and (131)I radiotracers. The comparative study proves that (131)I is more suitable than (99m)Tc for solid phase labeling of phosphate slurry.

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