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Hou Y.,Virginia Polytechnic Institute and State University | Cao S.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Miller J.S.,Missouri Botanical Garden | And 8 more authors.
Phytochemistry | Year: 2010

Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1-3. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC50 values of 25, 25 and 32 μM, respectively. © 2009 Elsevier Ltd. All rights reserved. Source


Cao S.,Virginia Polytechnic Institute and State University | Cao S.,Harvard University | Hou Y.,Virginia Polytechnic Institute and State University | Hou Y.,University of Wisconsin - Madison | And 6 more authors.
Chemistry and Biodiversity | Year: 2011

Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Cyphostemma greveana Desc. (Vitaceae) led to the identification of one macrolide, lasiodiplodin (1), three sesquiterpenoids, 12-hydroxy-15- oxoselina-4,11-diene (2), 1β,6α-dihydroxyeudesm-4(15)-ene (3), and (7R*)-opposit-4(15)-ene-1β,7-diol (5), and a new diterpenoid, 16,18-dihydroxykolavenic acid lactone (4). All the isolates were tested against the A2780 human ovarian cancer cell line, and compound 4 and a fraction containing 5 as the major constituent showed antiproliferative activities with IC 50 values of 0.44 μM (0.14 μg/ml) and 0.045 μg/ml, respectively. A partial synthesis of compound 5 was carried out, but the pure synthetic compound was inactive, indicating that the activity of the fraction containing it must be due to a very minor and as yet unidentified substance. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich. Source


Pan E.,Virginia Polytechnic Institute and State University | Harinantenaina L.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Callmander M.,Missouri Botanical Garden | And 7 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011

Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyzes of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC50 values of 0.18, 0.21, 0.17, and 0.29 μM line, and to the H460 human lung cancer cell line, with IC50 values of 0.16, 0.68, 0.37, and 0.48 μM, respectively. © 2010 Elsevier Ltd. All rights reserved. Source


Pan E.,Virginia Polytechnic Institute and State University | Harinantenaina L.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Miller J.S.,Missouri Botanical Garden | And 6 more authors.
Journal of Natural Products | Year: 2010

Investigation of the endemic Malagasy plant Bussea sakalava for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new diphenylpropanes 1-4 and the new cycloheptadibenzofuran 5; compound 5 has a previously unreported natural product skeleton. The structure elucidation of these compounds was based on the analysis of their 1D and 2D NMR and mass spectroscopic data. Compounds 1-5 were tested for antiproliferative activity against the A2780 human ovarian cancer cell line. © 2010 The American Chemical Society and American Society of Pharmacognosy. Source


Pan E.,Virginia Polytechnic Institute and State University | Cao S.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Miller J.S.,Missouri Botanical Garden | And 6 more authors.
Natural Product Communications | Year: 2010

Investigation of a Malagasy endemic plant identified as Symphonia pauciflora Baker (Clusiaceae) for antiproliferative activities against the A2780 ovarian cancer cell line led to the isolation of a new compound identified as 2-(3,3-dimethylallyl)-7-methoxy-1,5,6-trihydroxy-2″,2″- dimethylpyrano(6″,5″:3,4) xanthone (1) and the two known guttiferones A (2) and I (3). The structure elucidation of 1 was based on the analysis of its 1D and 2D NMR and mass spectral data. Compound 1 showed good antiproliferative activity with an IC50 value of 3.8 μM against the A2780 human ovarian cancer cell line, while the known guttiferone analogues (2 and 3) exhibited moderate activities with IC50 values of 8.3 μM and 7.8 μM, respectively. Source

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