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Rasamison V.E.,Center National dApplication des Recherches Pharmaceutiques | Rakotondraibe L.H.,Virginia Polytechnic Institute and State University | Rakotondraibe L.H.,Ohio State University | Slebodnick C.,Virginia Polytechnic Institute and State University | And 6 more authors.
Organic Letters | Year: 2014

The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM. © 2014 American Chemical Society.

Razafimandimbison S.G.,University of Stockholm | Appelhans M.S.,Leiden University | Rabarison H.,University of Antananarivo | Haevermans T.,CNRS Systematics, Biodiversity and Evolution Institute | And 11 more authors.
Molecular Phylogenetics and Evolution | Year: 2010

Ptaeroxylaceae is an Afro-Malagasy family containing three genera, Bottegoa, Cedrelopsis, and Ptaeroxylon. Although the family is morphologically well delimited, it is currently considered part of the subfamily Spathelioideae in a broadly circumscribed orange family (Rutaceae). The Malagasy Cedrelopsis has traditionally been associated with different families of the order Sapindales and its phylogenetic placement in Rutaceae sensu lato has yet to be tested with molecular data. The present molecular phylogenetic study reaffirms the monophyly of Ptaeroxylaceae and its placement in Spathelioideae. Therefore, molecules and morphology support close affinities between Bottegoa, Cedrelopsis, and Ptaeroxylon and also their current generic circumscriptions. We report a case of an evolutionary change from one-seeded to two-seeded carpels within the Harrisonia-Cneorum-Ptaeroxylaceae clade of Spathelioideae. Finally, the sister-group relationship between the African Bottegoa and the Afro-Malagasy Ptaeroxylon-Cedrelopsis clade suggests an African origin of Cedrelopsis. © 2010.

Adou E.,Virginia Polytechnic Institute and State University | Miller J.S.,Missouri Botanical Garden | Miller J.S.,New York Botanical Garden | Ratovoson F.,Missouri Botanical Garden | And 4 more authors.
Indian Journal of Experimental Biology | Year: 2010

Plant natural products have historically been very important to drug discovery and development, particularly in the anticancer field. This is illustrated by a discussion of the structures and activities of camptothecin and its analogues, paclitaxel (Taxoi®), the vinca alkaloids vinblastine and vincristine, and podophyllotoxin and its analogues. A description of the isolation of one new and three known cardenolides from the Madagascar plant Pentopetia androsaemifolia is then provided as an example of this approach to drug discovery. The paper concludes with a brief discussion of betulinic acid, an old compound which is being developed into an anticancer and anti-HIV agent, and ipomoeassin F, an interesting antiproliferative compound isolated from a plant collected in Suriname.

Cao S.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Callmander M.,Missouri Botanical Garden | Randrianaivo R.,Missouri Botanical Garden | And 3 more authors.
Phytochemistry | Year: 2010

A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside I (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4′-O-cinnamoyl cleomiscosin A) were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC50 value of 1.2 μM. © 2009 Elsevier Ltd. All rights reserved.

Harinantenaina L.,Virginia Polytechnic Institute and State University | Brodie P.J.,Virginia Polytechnic Institute and State University | Callmander M.W.,Missouri Botanical Garden | Razafitsalama L.J.,Missouri Botanical Garden | And 3 more authors.
Natural Product Communications | Year: 2012

Antiproliferative bioassay-guided fractionation of the ethanol extract of the endemic Malagasy Rubiaceous plant Tarenna grevei led to the isolation of two new antiproliferative oxygenated oleanane triterpene saponins. The structures of the two active compounds were elucidated as 23-hydroxylongispinogenin 3-O-β-D-glucopyranoside (1) and longispinogenin 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside (3) by analyses of their spectral data including 1D- and 2D-NMR spectroscopy and chemical evidence. Compounds 1 and 3 displayed moderate antiproliferative activity against the A2780 ovarian cancer cell line with IC50 values of 7.6 and 4 mM, respectively.

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