Lesage S.,University Pierre and Marie Curie |
Le Ber I.,University Pierre and Marie Curie |
Le Ber I.,Center National Of Reference Des Demences Rares |
Condroyer C.,University Pierre and Marie Curie |
And 10 more authors.
Brain | Year: 2013
The recently identified C9orf72 gene accounts for a large proportion of amyotrophic lateral sclerosis and frontotemporal lobar degenerations. As several forms of these disorders are associated with parkinsonism, we hypothesized that some patients with Parkinson's disease or other forms of parkinsonism might carry pathogenic C9orf72 expansions. Therefore, we looked for C9orf72 repeat expansions in 1446 unrelated parkinsonian patients consisting of 1225 patients clinically diagnosed with Parkinson's disease, 123 with progressive supranuclear palsy, 21 with corticobasal degeneration syndrome, 43 with Lewy body dementia and 25 with multiple system atrophy-parkinsonism. Of the 1446 parkinsonian patients, five carried C9orf72 expansions: three patients with typical Parkinson's disease, one with corticobasal degeneration syndrome and another with progressive supranuclear palsy. This study shows that (i) although rare, C9orf72 repeat expansions may be associated with clinically typical Parkinson's disease and also with other parkinsonism; (ii) in several patients, parkinsonism was levodopa-responsive and remained pure, without associated dementia, for >10 years and (iii) interestingly, all C9orf72 repeat expansion carriers had positive family histories of parkinsonism, degenerative dementias or amyotrophic lateral sclerosis. This study also provides the tools for identifying parkinsonian patients with C9orf72 expansions, with important consequences for genetic counselling. © 2013 The Author.
Planche V.,Service de Neurologie |
Gibelin M.,Reseau NeuroSEP Auvergne |
Cregut D.,Center Memoire Of Ressources Et Of Recherche |
Pereira B.,Delegation a la recherche clinique et a linnovation |
And 3 more authors.
European Journal of Neurology | Year: 2016
Background and purpose: Few studies have investigated the differences in cognitive skills between the three subtypes of multiple sclerosis (MS) and they confounded the course of the disease with the duration of the disease and the physical disability. Moreover, they were not population based. Methods: This was a retrospective analysis of cognitive testing from the database of a French programme for MS care. The pattern and the frequency of cognitive impairment in secondary progressive (SP), primary progressive (PP) and late relapsing-remitting (LRR, disease duration of more than 10 years) MS were compared. Results: A total of 101 patients with MS (41 LRRMS, 37 SPMS, 23 PPMS) were included. 63.0% had a significant cognitive impairment. After controlling for age, sex, Expanded Disability Status Scale, disease duration and education level, patients with SPMS were at least 2-fold more frequently impaired than patients with LLRMS in information processing speed (P = 0.005), executive functions (P = 0.04), verbal fluency (P = 0.02), verbal episodic memory (P = 0.04), working memory (P = 0.02) and visuospatial construction (P = 0.01). The number of patients with at least one or two deficient cognitive domain(s) was higher in the SPMS group than in the LRRMS group (P = 0.002 and P < 0.001). Patients with PPMS were more frequently impaired in verbal fluency (P = 0.046) than patients with LRRMS and they more often presented at least one impaired cognitive domain (P = 0.03). SPMS and PPMS groups differed only for visuospatial construction (P = 0.02). Conclusion: In this population-based study, patients with a progressive subtype of MS were more frequently and more severely impaired than patients with RRMS, even after more than 10 years of disease. © 2016 European Academy of Neurology.
Mulin E.,University of Nice Sophia Antipolis |
Mulin E.,Center Memoire Of Ressources Et Of Recherche |
Zeitzer J.M.,Stanford University |
Zeitzer J.M.,VA Palo Alto Health Care System |
And 5 more authors.
Journal of Alzheimer's Disease | Year: 2011
Apathy is the most frequently reported neuropsychiatric symptom across all stages of Alzheimer's disease (AD). Both apathy and sleep disorders are known to have independent negative effects on the quality of life in individuals with AD. The aim of this study was to assess the relationship between apathy and sleep/wake patterns in individuals with AD using ambulatory actigraphy. One hundred and three non-institutionalized individuals with AD wore a wrist actigraph continuously over seven consecutive 24-h periods. Apathy was assessed using the Neuropsychiatric Inventory. Daytime mean motor activity (dMMA) was calculated from daytime wrist actigraphy data. Actigraphic parameters of sleep included total sleep time (TST), wake after sleep onset (WASO), time in bed (TIB), WASO normalized by TIB, sleep latency, and nighttime mean motor activity (nMMA). Among the 103 individuals with AD (aged 76.9 ± 7.2 years; MMSE = 21.4 ± 4.3), those with apathy had significantly lower dMMA, higher WASO (both raw and normalized), and spent more time in bed during the night than those without apathy. Sleep latency, nMMA and TST did not differ significantly between the two subgroups. To our knowledge, this study is the first to identify a relationship between apathy and sleep disturbance in those with mild or moderate AD: apathy was associated with increased TIB during the night and more WASO. These results suggest that AD patients with apathy have less consolidated nocturnal sleep than those without apathy. © 2011 - IOS Press and the authors. All rights reserved.
PubMed | Service de Neurologie, Delegation a la recherche clinique et a linnovation, Reseau NeuroSEP Auvergne and Center Memoire Of Ressources Et Of Recherche
Type: Comparative Study | Journal: European journal of neurology | Year: 2016
Few studies have investigated the differences in cognitive skills between the three subtypes of multiple sclerosis (MS) and they confounded the course of the disease with the duration of the disease and the physical disability. Moreover, they were not population based.This was a retrospective analysis of cognitive testing from the database of a French programme for MS care. The pattern and the frequency of cognitive impairment in secondary progressive (SP), primary progressive (PP) and late relapsing-remitting (LRR, disease duration of more than 10years) MS were compared.A total of 101 patients with MS (41 LRRMS, 37 SPMS, 23 PPMS) were included. 63.0% had a significant cognitive impairment. After controlling for age, sex, Expanded Disability Status Scale, disease duration and education level, patients with SPMS were at least 2-fold more frequently impaired than patients with LLRMS in information processing speed (P=0.005), executive functions (P=0.04), verbal fluency (P=0.02), verbal episodic memory (P=0.04), working memory (P=0.02) and visuospatial construction (P=0.01). The number of patients with at least one or two deficient cognitive domain(s) was higher in the SPMS group than in the LRRMS group (P=0.002 and P<0.001). Patients with PPMS were more frequently impaired in verbal fluency (P=0.046) than patients with LRRMS and they more often presented at least one impaired cognitive domain (P=0.03). SPMS and PPMS groups differed only for visuospatial construction (P=0.02).In this population-based study, patients with a progressive subtype of MS were more frequently and more severely impaired than patients with RRMS, even after more than 10years of disease.
Konig A.,Center Memoire Of Ressources Et Of Recherche |
Konig A.,Maastricht University |
Aalten P.,Maastricht University |
Verhey F.,Maastricht University |
And 4 more authors.
International Journal of Geriatric Psychiatry | Year: 2014
Background Neuropsychiatric symptoms, such as apathy, have an important impact on the quality of life of both patients diagnosed with dementia and their caregivers and represent a strong predictor of progression of the illness. Current clinical assessment methods risk bias resulting from the assessor's subjectivity, pointing to a need for additional objective and systematic assessment tools. Therefore, the use of information and communication technologies (ICT) such as actigraphy and automatized video monitoring are of interest in addition to current assessment methods. Aim The goal of this study is to give an overview of current assessment tools for apathy in clinical practice and new approaches to assessment methods with the help ICT. Methods This study was conducted with the use of narrative literature overview. Results There is evidence that apart from the currently used assessment methods for apathy, new ICT approaches could provide clinicians with valuable additional information for an earlier detection and therefore more accurate diagnosis of apathy. Conclusions There are no ICT techniques specifically designed for the assessment of apathy, but nevertheless several techniques seem to be promising and deserve more study. © 2013 John Wiley & Sons, Ltd.
PubMed | Center hospitalier University Martinique, McGill University, Center hospitalier et University Martinique, University of Paris Descartes and Center Memoire Of Ressources Et Of Recherche
Type: | Journal: Geriatrie et psychologie neuropsychiatrie du vieillissement | Year: 2017
The mini mental state examination (MMSE) has become a benchmark for the screening and follow-up of cognitive impairment. The numerous translations of the MMS into other languages attest to its popularity. Clinical practice suggests that the consensual French version from the Greco (Groupe de rflexion sur les valuations cognitives - Research working group for cognitive assessment) is not adapted to the West-Indies population because of the low socio-economic level and the widespread use of the Creole language among the elderly population. Modification of certain items by a multidisciplinary committee made it possible to adapt the instrument to the Creole culture. This procedure increases comprehension of the instrument, and should lead to improved detection of cognitive impairment in the West-Indies.
Stoykova R.,University of Bordeaux Segalen |
Stoykova R.,Center Memoire Of Ressources Et Of Recherche |
Matharan F.,University of Bordeaux Segalen |
Dartigues J.-F.,University of Bordeaux Segalen |
And 2 more authors.
International Psychogeriatrics | Year: 2011
Background: The objective of this study was to investigate the relationship between social network and cognitive decline, taking into account the potential bias of reverse causality. Methods: The study sample comprised 2055 elderly participants without dementia. We assessed baseline social functioning across four variables: size of social network, satisfaction with relationships, perception of being understood, and participation in social activities. A neuropsychological battery was proposed at baseline and repeated throughout follow-up. Linear mixed models were used to investigate the relationship between social network and baseline cognitive performances and cognitive decline during the 20-year follow-up. Results: When controlling for the reverse causality bias by excluding participants who developed dementia during the study follow-up and after adjusting for covariates, the results showed that better social functioning at baseline was associated with better initial performances in the Isaacs Set Test and the Wechsler Paired Associate Test. However, there was no significant association with further cognitive decline. By contrast, when the bias of reverse causality was not controlled for (i.e. no exclusion of participants who developed dementia), the association between social network and global cognitive decline measured by MMSE was found to be statistically significant. Conclusion: With the opportunity to exclude participants who developed dementia, and the particularly long follow-up of participants, we were able to investigate the relationship between social networks and age-related cognitive decline with a minimization of reverse causality bias. The results suggest that even though higher social functioning is concomitantly associated with better cognitive performances, it may not prevent subsequent decline. Copyright © 2011 International Psychogeriatric Association.
Effect of a non-pharmacological intervention, Voix dOr®, on behavior disturbances in Alzheimer disease and associated disorders [Effet dune intervention non médicamenteuse, Voix dOr®, sur les troubles du comportement dans la maladie dAlzheimer ou une maladie apparentée]
Delphin-Combe F.,Center Memoire Of Ressources Et Of Recherche |
Rouch I.,Center Memoire Of Ressources Et Of Recherche |
Martin-Gaujard G.,Center Memoire Of Ressources Et Of Recherche |
Relland S.,Center Memoire Of Ressources Et Of Recherche |
And 2 more authors.
Geriatrie et Psychologie Neuropsychiatrie du Vieillissement | Year: 2013
An innovative non-pharmacological intervention called Voix d'Or® (Golden Voice) was proposed in the Cognitive behavioral unit (CBU) of the Memory center at the Hospices civils in Lyon. Voix d'Or® offers eight sound activities disseminated via an audio device based on different approaches sociotherapeutic (music therapy, reminiscence, relaxation, reorientation in reality). The aim of this study was to test the effects of the Voix d'Or® program on behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease hospitalized in the CBU. Twenty four patients with agitation and/or apathy and/or anxiety and/or depression were included. Patients were randomly selected in the intervention group exposed to Voix d'Or versus a control group exposed to usual occupational activities. Patients were assessed before (T0) and after (T1) the intervention period. Several variables were measured: frequency and severity of behavioral disorders, anxiety, depression, agitation and apathy. A significant improvement of anxiety level between T0 and T1was observed in the group with Voix d'Or® compared to the control group. This study suggests that this non-pharmacological intervention may be beneficial on anxiety in patients with Alzheimer's disease. Copyright © 2007 John Libbey Eurotext - All rights reserved.
David R.,Center Memoire Of Ressources Et Of Recherche |
Mulin E.,Center dInnovation et dUsage en Sante S |
Mallea P.,Center Memoire Of Ressources Et Of Recherche |
Robert P.H.,Center dInnovation et dUsage en Sante S
Pharmaceuticals | Year: 2010
Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer's disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy. © 2010 by the authors; licensee MDPI, Basel, Switzerland.
Robert P.H.,Center Memoire Of Ressources Et Of Recherche |
Mulin E.,University of Nice Sophia Antipolis |
Leone E.,University of Nice Sophia Antipolis |
David R.,University of Nice Sophia Antipolis
Revue de Geriatrie | Year: 2010
Apathy is an important behavioural syndrome in Alzheimer's disease and in various neuropsychiatric and geriatric disorders. In light of recent research and the renewed interest in the correlates and impacts of apathy, and in its treatments, it is important to develop diagnostic criteria that could be widely accepted, and easily applied in practice and research settings. Meeting these needs is the focus of the task force work of the "Association Française de Psychiatrie Biologique", the European Psychiatric Association, the European Alzheimer's Disease Consortium and experts from Europe, Australia and North America). Apathy is defined as a disorder of motivation that persists over time and should meet the following requirements. Firstly, the core feature of apathy, diminished motivation, must be present for at least four weeks; secondly two of the three dimensions of apathy (reduced goal-directed behaviour, goal-directed cognitive activity, and emotions) must also be present; thirdly there should be identifiable functional impairments attributable to the apathy. Finally, exclusion criteria are specified to exclude symptoms and states that mimic apathy. © La Revue de Gériatrie.