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Dreuil-lès-Amiens, France

Charfi K.,University of Monastir | Mansour W.,University of Monastir | Ben Haj Khalifa A.,Center Hospitalo University Taher Sfar | Mastouri M.,University of Monastir | And 3 more authors.
Diagnostic Microbiology and Infectious Disease | Year: 2015

A retrospective epidemiological survey was carried out to determine the prevalence of carbapenemase producers among enterobacterial clinical isolates recovered in the center of maternity and neonatology of Monastir (Tunisia). PCR screening identified 1 OXA-48 and 2 OXA-204 producers, which coexpressed the CTX-M-15 or the CMY-4 β-lactamases. PCR mapping showed that the blaOXA-48 gene was carried by a Tn1999.2 transposon, whereas the blaOXA-204 gene was part of the Tn2016 transposon-like structure. The OXA-48- or OXA-204-producing Klebsiella pneumoniae clinical isolates and the OXA-204-expressing Escherichia coli clinical isolate belonged to the widespread sequence types ST11, ST101, and ST617, respectively. The OXA-204 enzyme, which is a point derivative of the OXA-48 carbapenemase, had hitherto been reported in 2013 from K. pneumoniae isolate. Our study shows for the first time the dissemination of this resistance marker in E. coli strain. The coproduction of OXA-204 with CTX-M-15 and CMY-4 enzymes may potentiate the risk of multiresistance and may enhance the risk of dissemination. © 2015 Elsevier Inc.


Lefrere J.-J.,Sanguine | Lefrere J.-J.,Center Hospitalo University dAmiens | Berche P.,University of Paris Descartes
Annales d'Endocrinologie | Year: 2010

Pioneer in the field of hormone therapy, Charles-Edward Brown-Séquard (1817-1894) tried to stop the effects of aging on his contemporaries by injecting animal testicle extracts. His therapy was very popular in the last years of the 19th century. He even had followers in the following century, amongst whom Serge Voronoff (1866-1951), who grafted monkey testicles in replacement of human ones, or Paul Niehans (1882-1971) who practiced therapy using calf embryo cells in Switzerland. © 2010 Elsevier Masson SAS.


Lefrere J.-J.,Sanguine | Lefrere J.-J.,Center Hospitalo University dAmiens | Berche P.,University of Paris Descartes
Annales Medico-Psychologiques | Year: 2010

During the First World War, Dr Edgar Berillon (1859-1948) developed a theory according to which the French and German physical and physiological characteristics are very different. His theories were seriously considered by the scientific and medical community of the time, especially as they contributed to the general propaganda against the enemy. This scientificopatriotic delirium was presented in several publications, the content of which appear both grotesque and false today. © 2010 Elsevier Masson SAS.


Jaulin P.,rue de Bellechasse | Lefrere J.-J.,Sanguine | Lefrere J.-J.,Center Hospitalo University dAmiens
Transfusion Clinique et Biologique | Year: 2010

The pioneers of blood transfusion first appeared in the 17th century, mainly in France and England, through animal experimentation, followed by some attempts in the healthy or sick. In France, the names of Dom Robert and Jean-Baptiste Denis belong to the beginning of the adventure of transfusion. Transfusions were then made with a total lack of knowledge of immunological danger. Following the death of a transfused patient, a death most likely related to acute intravascular hemolysis, the practice of transfusion was prohibited, on both sides of the Channel, by decision of Parliament. © 2010 Elsevier Masson SAS.


Lefrere J.-J.,Sanguine | Lefrere J.-J.,Center Hospitalo University dAmiens | Berche P.,University of Paris Descartes
Transfusion Clinique et Biologique | Year: 2010

The discovery of ABO blood group was a major step in mastering transfusion therapy. Karl Landsteiner (1868-1843) was the author of this discovery. This paper retraces the hard career of this American scientist of Austrian origin, and describes the circumstances that led his research to the discoveries, which were turning points in the history of the immunology. © 2009 Elsevier Masson SAS. All rights reserved.

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