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Zehn D.,Center hospitalier University Vaudois | King C.,University of Basel | Bevan M.J.,University of Washington | Palmer E.,University of Basel
Cellular and Molecular Life Sciences | Year: 2012

Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation, and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR] following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact the formation of effector and memory T cells. © 2011 Springer Basel AG.

Davison A.C.,Ecole Polytechnique Federale de Lausanne | Gholamrezaee M.M.,Center hospitalier University Vaudois
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2012

We describe a prototype approach to flexible modelling for maxima observed at sites in a spatial domain, based on fitting of max-stable processes derived from underlying Gaussian random fields. The models we propose have generalized extreme-value marginal distributions throughout the spatial domain, consistent with statistical theory for maxima in simpler cases, and can incorporate both geostatistical correlation functions and random set components. Parameter estimation and fitting are performed through composite likelihood inference applied to observations from pairs of sites, with occurrence times of maxima taken into account if desired, and competing models are compared using appropriate information criteria. Diagnostics for lack of model fit are based on maxima from groups of sites. The approach is illustrated using annual maximum temperatures in Switzerland, with risk analysis proposed using simulations from the fitted max-stable model. Drawbacks and possible developments of the approach are discussed. © 2011 The Royal Society.

Peters S.,Center hospitalier University Vaudois | Meylan E.,Ecole Polytechnique Federale de Lausanne
Current Opinion in Oncology | Year: 2013

Purpose of Review: The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. Recent Findings: After evoking the use of zoledronic acid as the established standard of care until recently, the new class of drugs available to prevent skeletal related events and targeting receptor activator of nuclear factor-kappa B (RANK) will be emphasized, reporting on denosumab clinical trials, a RANK-ligand (RANKL) targeting monoclonal antibody. Biological hypothesis regarding their mechanisms of action as well a potential direct impact on tumor cells are described according to the most recent laboratory as well as hypothesis-generating clinical data. Summary: Targeting the RANK pathway is an efficient way to prevent complications of bone metastases in NSCLC. Interesting additional direct effects on tumor biology and evolution are being analyzed and prospectively assessed in clinical trials. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Center Hospitalier University Vaudois | Date: 2013-11-06

A medicament comprising a therapeutically effective amount of at least one omega-3 polyunsaturated fatty acid for use in the reduction and prevention of post-ischemic damages in patients undergoing elective surgery.

Center Hospitalier University Vaudois | Date: 2012-12-21

A treated surface of a device (

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