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Lapierre A.,University of Lyon | Selmaji I.,Center Hospitalier University Of Marrakech | Samlali H.,Center Hospitalier University Of Casablanca | Brahmi T.,University of Lyon | Yossi S.,University of Lyon
Cancer/Radiotherapie | Year: 2016

Purpose: Olfactory neuroblastoma or esthesioneuroblastoma is a rare entity among head and neck neoplasms. In this paper, we report the experience of our institution and compare it with a comprehensive review of the literature. Patients and methods: We retrospectively analysed clinical and treatment data of patients referred to the Lyon Sud University Hospital (France) for histologically proven olfactive esthesioneuroblastoma. Results: Ten patients treated between 1993 and 2015 have been analysed. Disease stage at diagnosis, according to the Kadish staging system, was C in 90% of cases. Median follow-up was 136 months. Ten-year overall survival was 90%. Five- and ten-year progression-free survival were 70% and 50%. Nine patients (90%) underwent surgical resection first. Seven of the nine patients who underwent resection (77%) received adjuvant three-dimensional (3D)-conformal radiotherapy (n = 7), intensity-modulated radiotherapy (n = 1), or volumetric arctherapy (n = 1). The mean dose to the tumour volume was 61. Gy. None of the patients received elective nodal irradiation. Two patients received concurrent chemotherapy. Five patients (50%) presented with disease recurrence, which was local (n = 1), nodal (n = 2) and cerebral (n = 2). Conclusion: Our results are consistent with the literature. Because of the lack of prospective study and the low number of cases in the literature, each institution's experience is of the utmost important to improve standardised management of these tumours. © 2016 Société française de radiothérapie oncologique (SFRO). Source


Boufettal H.,Center Hospitalier University Of Casablanca | Mahdaoui S.,Center Hospitalier University Of Casablanca | Noun M.,Center Hospitalier University Of Casablanca | Hermas S.,Center Hospitalier University Of Casablanca | And 4 more authors.
Revue de Medecine Interne | Year: 2011

Granulomatous mastitis is a rare inflammatory disorder. Its etiology remains unknown. We report a 42-year-old female who presented with an idiopathic granulomatous mastitis. Outcome was favourable with corticosteroids. The disease course of this entity is unpredictable and a consensual treatment is difficult. © 2010. Source


Mahdaoui S.,Center Hospitalier University Of Casablanca | Mahdaoui S.,Central University of Costa Rica | Hermas S.,Center Hospitalier University Of Casablanca | Ouadirga F.,Center Hospitalier University Of Casablanca | And 5 more authors.
Medecine Therapeutique Medecine de la Reproduction, Gynecologie et Endocrinologie | Year: 2012

The primary non Hodgkin's lymphoma of the uterus is rare, since only seven cases have previously been published. This rarity explains certain difficulty of the histological diagnosis and on the absence of a clearly established therapeutic strategy. We report a case of primary non Hodgkin's lymphoma of the uterine corpus ; diagnosed by endometrial biopsy during explorative laparotomy, in a 31-year-old patient suffering from uterine bleeding. Pathological analysis concluded the uterine mass to represent diffuse large B-cell lymphoma. Further staging had not revealed nodal or other extranodal localization [Ann Arbor stage IE] and there were no signs of recurrence during follow-up. Therefore the diagnostic criteria for true primary non Hodgkin's lymphoma of the uterine corpus were met. The patient was successfully treated by chemotherapy with CHOP. After 30 months of follow-up, she has no residual or recurrent disease. Source

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