Hopital Notre Dame Du Center Hospitalier Of Luniversite Of Montreal

Montréal, Canada

Hopital Notre Dame Du Center Hospitalier Of Luniversite Of Montreal

Montréal, Canada
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Forghani R.,Jewish General Hospital | Forghani R.,Segal Cancer Center | Forghani R.,Lady Davis Institute for Medical Research | Kelly H.,Massachusetts General Hospital | And 10 more authors.
Journal of Computer Assisted Tomography | Year: 2017

Objective Dual-energy computed tomography (CT) 40-keV virtual monochromatic images (VMIs) have been reported to improve visualization of head and neck squamous cell carcinoma, but a direct comparison to single-energy CT (SECT) is lacking, and there is debate regarding subjective user preference. We compared 40-keV VMIs with SECT and performed a subjective evaluation of their utility and acceptability for clinical use. Methods A total of 60 dual-energy CT and 60 SECT scans from 2 different institutions were evaluated. Tumor conspicuity was evaluated objectively using absolute and relative attenuation and subjectively by 3 head and neck specialists and 3 general radiologists. Results Tumors had significantly higher absolute and relative attenuation on 40-keV VMIs (P < 0.0001). Subjectively, the 40-keV VMIs improved visualization, with substantial (κ, 0.61-0.80) to almost perfect (κ, 0.81-1) interrater agreements. Conclusions The 40-keV VMIs improve tumor visibility objectively and subjectively both by head and neck specialists and general radiologists. © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Isidean S.D.,McGill University | Coutlee F.,McGill University | Coutlee F.,Hopital Notre Dame Du Center Hospitalier Of Luniversite Of Montreal | Franco E.L.,McGill University
Expert Review of Molecular Diagnostics | Year: 2014

Cervical cancer screening incorporating high-risk human papillomavirus (HPV) detection has become the preferred screening strategy in some countries and is increasingly more widespread in other countries with organized or opportunistic screening programs. Given knowledge that high-risk HPV genotypes differ in their oncogenic potential, commercial HPV assays with genotyping capabilities have been developed and have garnered attention in the recent literature. The cobas® 4800 HPV Test is a qualitative multiplex assay that provides specific genotyping information for HPV types 16 and 18, while concurrently detecting 12 other high-risk HPV genotypes as a pooled result. It is currently the only clinically validated, US FDA-approved assay with this capability. Since HPV types 16 and 18 have been designated as conferring the greatest risk for cervical disease, their detection may prove useful in guiding patient management. © 2014 Informa UK, Ltd.

Leduc B.E.,Institute Of Readaptation Gingras Lindsay Of Montreal | Fournier C.,Institute Of Readaptation Gingras Lindsay Of Montreal | Jacquemin G.,Institute Of Readaptation Gingras Lindsay Of Montreal | Lepage Y.,University of Montréal | And 3 more authors.
Journal of Spinal Cord Medicine | Year: 2015

Objective: The objective of this study is to evaluate the efficacy of midodrine in the treatment of anejaculation in men with spinal cord injury (SCI). Study design: Prospective, double-blind, randomized, placebo-controlled pilot study. Method: Men with anejaculation associated with SCI (level of injury above T10) of more than 1 year in duration were approached. Those with no ejaculatory response to one penile vibratory stimulation (PVS) trial were assigned in a double-blind manner to one of the two following interventions once a week for a maximum of 3 weeks or until ejaculation occurred: oral administration of flexible midodrine (7.5-22.5 mg max) followed by PVS (group M), or oral administration of flexible sham-midodrine (placebo) followed by PVS (group P). Sociodemographic data, medical characteristics, and plasma desglymidodrine concentration were collected for all participants. Outcome measure: Ejaculation success rate in each group. Results: Among the 78 men approached, 23 participants (level of SCI: C4-T9) were randomized. Three participants abandoned the study and 20 completed the study; 10 were assigned to group M, 10 to group P. Ejaculation was reached for one participant of group M and for two participants of group P. Autonomic dysreflexia associated to PVS occurred in three patients. Conclusion: In this small sample study, treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS. © The Academy of Spinal Cord Injury Professionals, Inc. 2015.

Bergeron M.B.,University of Montréal | Soglio D.B.-D.,University of Montréal | Maietta A.,Hopital Notre Dame Du Center Hospitalier Of Luniversite Of Montreal | Fournet J.-C.,University of Montréal | And 3 more authors.
Pediatric and Developmental Pathology | Year: 2010

Females with 46,XY complete gonadal dysgenesis are at significant risk of developing germ cell tumors, mostly gonadoblastomas. We present here the case of 2 half-sisters, sharing the same father, diagnosed with 46,XY complete gonadal dysgenesis. The 1st sister developed a gonadoblastoma and an invasive dysgerminoma, whereas the 2nd sister developed a gonadoblastoma and an invasive choriocarcinoma within the same gonad. No SRY mutation, chromosome abnormalities, or mosaicism were detected in blood. Single nucleotide polymorphism (SNP) profiling of the choriocarcinoma revealed a complex hyperdiploid pattern with gains of 1 to 4 copies of material from several autosomes, as well as the loss of the Y chromosome and a homozygous SNP profile without copy number change for the X chromosome. Our results are in agreement with the recurrent chromosome gains and losses previously published in germ cell tumors, and the coexistence of both tumors within the same gonad suggests that choriocarcinomas may derive from gonadoblastomas. © 2010 Society for Pediatric Pathology.

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