Center Hospitalier Of Douai

Douai, France

Center Hospitalier Of Douai

Douai, France
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Bence C.,Service dAddictologie | Bonord A.,Service de Prise en Charge de la Toxicomanie et de la Dependance | Rebillard C.,Service de Psychiatrie Perinatale | Vaast P.,Center Pluridisciplinaire Of Diagnostic Prenatal | And 5 more authors.
Pediatrics | Year: 2016

Tianeptine, an atypical antidepressant, has been found to exhibit a potential for abuse. The use of therapeutic doses of tianeptine during pregnancy has never raised safety concerns. However, the impact of tianeptine abuse on the mother-child dyad has never been assessed. We report herein the case of a female patient who presented with dependence on tianeptine, with the use of >650 mg of the drug per day. She had 2 successive pregnancies with similar doses. The state of dependence remained unidentified throughout the first pregnancy, but just after delivery, her full-term newborn exhibited unexpected neonatal abstinence syndrome (NAS). The NAS was successfully treated with morphine, although both the mother's and newborn's urine drug screen was negative. The causality of tianeptine in inducing NAS was retrospectively assessed as "probable" by using a validated causality algorithm. During the second pregnancy, this patient sought addiction treatment and was admitted for residential detoxification treatment in her seventh month of pregnancy. Delivery occurred at full term with a low birth weight neonate. No further developmental insults or medical problems were subsequently identified in the 2 children. Maternal tianeptine dependence during pregnancy may induce a type of NAS that mimics opiate NAS. This finding appears to be consistent with a recent finding of the agonist action of tianeptine on the opiate μ-receptor. © 2016 by the American Academy of Pediatrics.


Gnemmi V.,Lille University Hospital Center | Gnemmi V.,University of Lille Nord de France | Leleu X.,Lille University Hospital Center | Provot F.,Lille University Hospital Center | And 3 more authors.
American Journal of Kidney Diseases | Year: 2012

Waldenström macroglobulinemia is a rare low-grade hematologic malignancy due to clonal proliferation of B lymphocytes responsible for immunoglobulin M (IgM) monoclonal gammopathy secreted in serum. This disease is characterized by lymphoplasmacytic tumoral infiltration of bone marrow and various organs, especially the liver and spleen. Kidney involvement in Waldenström macroglobulinemia has been described previously with reports of various forms of glomerular injury: large intracapillary IgM pseudothrombi, cryoglobulinemia-associated membranoproliferative glomerulonephritis, or amyloidosis. Interstitial infiltration by tumoral B lymphocytes is another classic pattern. Conversely, tubular involvement in the form of myeloma-like casts or basement membrane deposition of monoclonal light chain (light-chain deposition disease) is unusual. We report the occurrence of cast nephropathy associated with light-chain deposition disease in 2 patients with Waldenström macroglobulinemia, which resulted in severe and prolonged kidney failure. © 2012 National Kidney Foundation, Inc.


PubMed | Montpellier University, University of Nantes, University of Strasbourg, University of Poitiers and 32 more.
Type: Journal Article | Journal: Human mutation | Year: 2015

Dent disease is a rare X-linked tubulopathy characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressive renal failure, and variable manifestations of other proximal tubule dysfunctions. It often progresses over a few decades to chronic renal insufficiency, and therefore molecular characterization is important to allow appropriate genetic counseling. Two genetic subtypes have been described to date: Dent disease 1 is caused by mutations of the CLCN5 gene, coding for the chloride/proton exchanger ClC-5; and Dent disease 2 by mutations of the OCRL gene, coding for the inositol polyphosphate 5-phosphatase OCRL-1. Herein, we review previously reported mutations (n = 192) and their associated phenotype in 377 male patients with Dent disease 1 and describe phenotype and novel (n = 42) and recurrent mutations (n = 24) in a large cohort of 117 Dent disease 1 patients belonging to 90 families. The novel missense and in-frame mutations described were mapped onto a three-dimensional homology model of the ClC-5 protein. This analysis suggests that these mutations affect the dimerization process, helix stability, or transport. The phenotype of our cohort patients supports and extends the phenotype that has been reported in smaller studies.


Guery B.,Lille 2 University of Health and Law | Poissy J.,Lille 2 University of Health and Law | El Mansouf L.,Center Hospitalier Of Douai | Sejourne C.,Center Hospitalier Of Douai | And 20 more authors.
The Lancet | Year: 2013

Background Human infection with a novel coronavirus named Middle East Respiratory Syndrome coronavirus (MERS-CoV) was first identified in Saudi Arabia and the Middle East in September, 2012, with 44 laboratory-confirmed cases as of May 23, 2013. We report detailed clinical and virological data for two related cases of MERS-CoV disease, after nosocomial transmission of the virus from one patient to another in a French hospital. Methods Patient 1 visited Dubai in April, 2013; patient 2 lives in France and did not travel abroad. Both patients had underlying immunosuppressive disorders. We tested specimens from the upper (nasopharyngeal swabs) or the lower (bronchoalveolar lavage, sputum) respiratory tract and whole blood, plasma, and serum specimens for MERS-CoV by real-time RT-PCR targeting the upE and Orf1A genes of MERS-CoV. Findings Initial clinical presentation included fever, chills, and myalgia in both patients, and for patient 1, diarrhoea. Respiratory symptoms rapidly became predominant with acute respiratory failure leading to mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Both patients developed acute renal failure. MERS-CoV was detected in lower respiratory tract specimens with high viral load (eg, cycle threshold [Ct] values of 22•9 for upE and 24 for Orf1a for a bronchoalveolar lavage sample from patient 1; Ct values of 22•5 for upE and 23•9 for Orf1a for an induced sputum sample from patient 2), whereas nasopharyngeal specimens were weakly positive or inconclusive. The two patients shared the same room for 3 days. The incubation period was estimated at 9-12 days for the second case. No secondary transmission was documented in hospital staff despite the absence of specific protective measures before the diagnosis of MERS-CoV was suspected. Patient 1 died on May 28, due to refractory multiple organ failure.


Amirou C.,Center Hospitalier Of Douai | Vaast I.,Consultation douleur
Douleur et Analgesie | Year: 2016

Patients with orofacial pains have a double traumatic effect by living with permanent effraction of pain and feeling stared with a dehumanizing look. It creates such a psychic disorganization that patients have to find new personal adaptation modalities. We shall see how the face-to-face psychotherapy is a specific approach for these patients. © 2016, Springer-Verlag France.


Ricard C.,Center Hospitalier Of Douai | Mellentin J.,Center Hospitalier Of Douai | Ben Abdallah Chabchoub R.,Service Route | Kingbede P.,Service Route | And 5 more authors.
Archives de Pediatrie | Year: 2015

In humans, Salmonella most often causes self-limiting gastroenteritis, but more severe symptoms such as sepsis and meningitis can also occur and can sometimes have a fatal outcome. Even if the meningitis is not fatal, sequelae such as epilepsy, cranial nerve palsies, and hydrocephalus can occur. In the United States, it has been estimated that approximately 6% of the human cases of salmonellosis can be attributed to contact with reptiles or amphibians. The infection may take place by direct contact between reptile and human or indirectly via contact with an environment contaminated with Salmonella from a reptile. Salmonella enterica subsp. enterica serotype Vitkin is a common gut inhabitant of reptiles. Though human cases due to this organism are exceedingly rare, it may infect young infants and immunocompromised individuals with a history of intimate associations with reptiles. Gastroenteritis is the most common presentation ; others include peritonitis, meningitis and bacteremia. We report a case of meningitis caused by S. enterica subsp. enterica serotype Vitkin in a 1-month-old child due to a pet turtle. © 2013 Elsevier Masson SAS.


Deprez A.,Center Devaluation Et Of Traitement Of La Douleur | Duneugardin P.,Center Hospitalier Of Douai
Douleur et Analgesie | Year: 2016

The links of primary attachments are essential in the development of the child and participate in identity construction. Numerous authors dealt with the theory of attachment and allowed us to better understand few concepts.With the help of this theory’s authors pioneers, we are interested, in this article, in the psycho-emotional development of the child by means of the link mother-child organized through the face and the attention dedicated to the child. © 2016 Springer-Verlag France


The pain clinics are the receptacle of a variety of painful requests. In front of the complexity, a multidisciplinary approach is required. How manage it? This article reviews the relationships between the consultation and the psychoanalysis therapies and then deals with other therapies, notably body-oriented psychotherapies. © 2015, Springer-Verlag France.


PubMed | Service de medecine interne, Service Route, Institute Of Pathologie Anatomie Et Cytologie Pathologiques and Center Hospitalier Of Douai
Type: | Journal: La Revue de medecine interne | Year: 2016

AA amyloidosis is a common but severe complication of many chronic inflammatory processes of infectious, autoimmune, or neoplastic origin. It frequently leads to renal damage, often presenting as a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in elderly people, but rarely complicated by AA amyloidosis.We report an 87-year-old female who presented with a nephrotic syndrome and a chronic inflammation, in whom the kidney biopsy showed secondary amyloidosis. Etiological investigations concluded an amyloidosis related to giant cell pan-aortitis, whereas there were no typical clinical signs for this diagnosis. Outcome was rapidly unfavourable despite the treatment.In case of chronic inflammation of unknown origin in elderly patients, aortitis complicating a giant cell arteritis should be looked for with imaging techniques, as clinical diagnosis of this presentation is difficult, whereas delayed diagnosis exposes to severe or fatal issues.


PubMed | Service Route and Center Hospitalier Of Douai
Type: Case Reports | Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | Year: 2015

In humans, Salmonella most often causes self-limiting gastroenteritis, but more severe symptoms such as sepsis and meningitis can also occur and can sometimes have a fatal outcome. Even if the meningitis is not fatal, sequelae such as epilepsy, cranial nerve palsies, and hydrocephalus can occur. In the United States, it has been estimated that approximately 6% of the human cases of salmonellosis can be attributed to contact with reptiles or amphibians. The infection may take place by direct contact between reptile and human or indirectly via contact with an environment contaminated with Salmonella from a reptile. Salmonella enterica subsp. enterica serotype Vitkin is a common gut inhabitant of reptiles. Though human cases due to this organism are exceedingly rare, it may infect young infants and immunocompromised individuals with a history of intimate associations with reptiles. Gastroenteritis is the most common presentation; others include peritonitis, meningitis and bacteremia. We report a case of meningitis caused by S.enterica subsp. enterica serotype Vitkin in a 1-month-old child due to a pet turtle.

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