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Maitre J.,University of Pau and Pays de lAdour | Serres I.,University of Pau and Pays de lAdour | Lhuisset L.,University of Pau and Pays de lAdour | Bois J.,University of Pau and Pays de lAdour | And 2 more authors.
Scandinavian Journal of Medicine and Science in Sports | Year: 2015

The aim was to determine in what extent physical activity influences postural control when visual, vestibular, and/or proprioceptive systems are disrupted. Two groups of healthy older women: an active group (74.0±3.8 years) who practiced physical activities and a sedentary group (74.7±6.3 years) who did not, underwent 12 postural conditions consisted in altering information emanating from sensory systems by means of sensory manipulations (i.e., eyes closed, cervical collar, tendon vibration, electromyostimulation, galvanic vestibular stimulation, foam surface). The center of foot pressure velocity was recorded on a force platform. Results indicate that the sensory manipulations altered postural control. The sedentary group was more disturbed than the active group by the use of tendon vibration. There was no clear difference between the two groups in the other conditions. This study suggests that the practice of physical activities is beneficial as a means of limiting the effects of tendon vibration on postural control through a better use of the not manipulated sensory systems and/or a more efficient reweighting to proprioceptive information from regions unaffected by the tendon vibration. © 2014 John Wiley & Sons A/S. Source


Shcherbinin S.,University of British Columbia | Chamoiseau S.,Center Hospitalier Of Bigorre | Celler A.,University of British Columbia
Physics in Medicine and Biology | Year: 2012

We investigated the quantitative accuracy of the model-based dual-isotope single-photon emission computed tomography (DI-SPECT) reconstructions that use Klein-Nishina expressions to estimate the scattered photon contributions to the projection data. Our objective was to examine the ability of the method to recover the absolute activities pertaining to both radiotracers: Tc-99m and I-123. We validated our method through a series of phantom experiments performed using a clinical hybrid SPECT/CT camera (Infinia Hawkeye, GE Healthcare). Different activity ratios and different attenuating media were used in these experiments to create cross-talk effects of varying severity, which can occur in clinical studies. Accurate model-based corrections for scatter and cross-talk with CT attenuation maps allowed for the recovery of the absolute activities from DI-SPECT/CT scans with errors that ranged 0-10% for both radiotracers. The unfavorable activity ratios increased the computational burden but practically did not affect the resulting accuracy. The visual analysis of parathyroid patient data demonstrated that our model-based processing improved adenoma/background contrast and enhanced localization of small or faint adenomas. © 2012 Institute of Physics and Engineering in Medicine. Source


Shcherbinin S.,University of British Columbia | Chamoiseau S.,Center Hospitalier Of Bigorre | Celler A.,University of British Columbia
Physics in Medicine and Biology | Year: 2013

We investigate the quantitative accuracy of the reconstruction of absolute 99mTc and 111In activities from 99mTc/ 111In dual-isotope SPECT studies. The separate reconstruction of two images is achieved by applying Monte Carlo simulation-based corrections for self-scatter and cross-talk between energy windows. For method evaluation, a series of 99mTc/111In physical phantom experiments was performed using a clinical SPECT/CT camera. The containers were filled with different ratios of 99mTc and 111In activities to create cross-talk with varying severity levels. In addition, we illustrate the performance of our method by reconstructing images from four simultaneous 99mTc/111In SPECT/CT studies of neuroendocrine patients. Similarly to the phantom experiments, clinical cases provide examples with different severity of cross-talk. Phantom experiments showed that Monte Carlo simulation-based corrections improved both quantitative accuracy and visual properties of 99mTc and 111In images. While the errors of absolute activities for both tracers in six containers ranged from 16% to 75% if no corrections for self-scatter and cross-talk were applied, these errors decreased to below 10% when images were reconstructed with the aforementioned corrections. These activities were measured using regions of interest larger than the true sizes of the containers in order to account for the spill-out effect. Analysis of patient studies confirmed that accurate simulation-based compensations improved resolution and contrast for both 99mTc and 111In images. © 2013 Institute of Physics and Engineering in Medicine. Source


Morin T.,Center Hospitalier Of Bigorre | Pariente A.,Center Hospitalier Of Pau | Lahmek P.,Center Hospitalier Emile Roux | Rabaud C.,University of Lorraine | And 2 more authors.
European Journal of Gastroenterology and Hepatology | Year: 2010

Objectives: To analyze the data (epidemiology, mode of transmission, course, and outcome) of a large series of patients with acute hepatitis C (AHC) in France. Methods: Prospective multicenter register, observational study. Results: A cohort of 126 patients with AHC was prospectively enrolled between 1999 and 2007. Fifteen (12%) were HIV coinfected. Suspected modes of hepatitis C virus transmission were drug use (38%), sexual contact (21%), nosocomial transmission (18%), and occupational exposure (12%). For 40% of the patients, AHC was revealed by jaundice. Spontaneous viral clearance occurred in 40% of the 72 patients observed for 3 months without treatment. Only jaundice and nosocomial/occupational transmission were predictive of spontaneous viral clearance. Ninety patients were treated with standard or pegylated interferonα alone (58%) or in combination with ribavirin (42%), for 24 weeks or less in 90%. In intention-to-treat, a sustained viral response was obtained in 58 of 78 (74%) hepatitis C virus monoinfected patients [19 of 22 (86%) with 24 weeks of pegylated interferon-α alone], but only six of 12 (50%) of HIV coinfected patients. Conclusion: AHC remains rare, and drug and sexual transmission are predominant. A 3-month follow-up after diagnosis avoids treatment for four out of 10 patients. Antiviral treatment is highly effective, 24 weeks of pegylated interferon-α alone being a good option. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source


Morin T.,Center Hospitalier Of Bigorre | Pariente A.,Center Hospitalier | Lahmek P.,Center Hospitalier Emile Roux
European Journal of Gastroenterology and Hepatology | Year: 2011

Background: Although risk factors and useful preventive measures are largely known, specific data about the course and prognosis of acute hepatitis C among healthcare workers is lacking. Aim: To analyze the data, course, and outcome of a series of patients with occupationally transmitted acute hepatitis C in France. Methods and Setting: An observational multicenter study based on two consecutive acute hepatitis C cohorts, retrospective then prospective, registered between 1993 and 2007, mostly in general hospitals. Results: A cohort of 23 patients with occupationally transmitted hepatitis C virus (HCV) was set up. Occupational accident registration was done in 14 (61%) cases. They were mainly women (n=14), with a mean age of 43 years. The disease was diagnosed during surveillance after exposure in 16 patients, and nine had hyperbilirubinemia. Early treatment was applied to nine of them, with eight who sustained viral response (SVR). Fourteen underwent surveillance: spontaneous viral clearance occurred in nine of them, with two relapses. Five patients with persistent HCV RNA 12 weeks after the diagnosis were then treated, with four SVR. Conclusion: Information and prevention of healthcare workers concerning occupational HCV transmission need to be improved, and all blood-exposure accidents should be registered. Spontaneous viral clearance occurred in half of the patients. Antiviral treatment was highly effective, with a SVR of 86%. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

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