Center Hospitalier National Of Nouakchott

Nouakchott, South Africa

Center Hospitalier National Of Nouakchott

Nouakchott, South Africa

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PubMed | Institute National Dhepato Virologie Of Nouakchott, Service Of Medecine Interne Du Center Hospitalier Daioun and Center Hospitalier National Of Nouakchott
Type: | Journal: The Pan African medical journal | Year: 2016

Rift Valley fever (RVF) is an arbovirus caused by an RNA virus belonging to family Bunyaviridae (genus phlebovirus). It is a zoonosis that primarily affects animals but it also has the capacity to infect humans, either by handling meat, runts of sick animals or, indirectly, by the bite of infected mosquitoes (Aedes sp, Anopheles sp, Culex sp). In most cases, RVF infection in humans is asymptomatic, but it can also manifest as moderate febrile syndrome with a favorable outcome. However, some patients may develop hemorrhagic syndrome and/or neurological damages with a fatal evolution. We present a case study of the development of 5 patients with RVF associated with hemorrhagic fever syndrome admitted to the internal medicine department at National Hospital Center in Nouakchott (Mauritania), in October 2015. The outcome was favorable for two of the five patients. The other 3 died, two of hemorrhagic shock and one of septic shock.


Tfeil Y.O.,Center Hospitalier National Of Nouakchott | Elmoctar C.A.O.,Center Hospitalier National Of Nouakchott | Ca M.O.,Center Hospitalier National Of Nouakchott | Jdoud C.O.,Center Hospitalier National Of Nouakchott
Andrologie | Year: 2010

Objective: To present the epidemiological, clinical and therapeutic features of urological emergencies in Mauritania, West Africa. Material and methods: The authors conducted a 5-year retrospective study that analyzed the epidemiological, clinical and therapeutic features of all urological emergencies admitted to the urology department of Nouakchott Central Hospital. Results: There were 1,200 urological emergencies. The mean age of the patients was 58.8 years (range one month-94 years). These patients had an age ≥60 years in 50.7% of the cases The sex ratio (M: F) was 20: 32. The most frequent illnesses were urinary retention (53%) and genitourinary system infections, which represented 16.8% of the cases. The gangrenes of male external genitalia (Fournier's gangrene) accounted for 4.3% of the cases and priapism 1.8%. In emergency, 300 surgical operations were performed. The most performed procedures were the installation of a suprapubic catheter (59.7%) and debridement of a gangrene of male external genitalia (16%). Conclusion: The most frequent urological emergency in our country was acute urinary retention. Serious illnesses, like gangrene of male external genitalia (Fournier's gangrene) and priapism, are not rare there. © 2010 Springer.


Boushab B.M.,Center hospitalier dAioun | Savadogo M.,Center Hospitalo University Of Yalgado Ouedraogo | Sow S.M.,Center Hospitalo University Of Donka | Soufiane S.,Center Hospitalier National Of Nouakchott
Revue d'Epidemiologie et de Sante Publique | Year: 2015

Background. - Rift Valley Fever (RVF) is a zoonotic arbovirosis. Among animals, it mainly affects ruminants, causing abortions in gravid females and deaths among young animals. In humans, RVF virus infection is usually asymptomatic or characterized by a moderate fever. However, in 1-3% of cases, the disease progresses to a severe form with 50% mortality. Objective. - Search for risk factors and to propose appropriate measures to prevent the potential for extension of the epidemic, and to make recommendations for disease monitoring and control. Methods. - This investigation involved human RVF cases reported between October 12 and November 20, 2012 in the area of Tagant in Mauritania. Arbovirosis diagnosis was established by the laboratory of the National Institute of Public Health Research in Nouakchott (Mauritania) in collaboration with the Pasteur Institute of Dakar (Senegal). Results. - Of 212 subjects, RVF serology was positive in 26 (12%). Among those seropositive for RVF, 11 (42%) had severe hemorrhagic forms. The case fatality rate was 91%. A series of animal abortions (cattle, sheep and goats) was observed in the area where all but two subjects resided. Exposure to potential risk factors for RVF virus infection was found in all patients. Conclusion. - Mortality is very high in the hemorrhagic forms of RVF. Disease prevention is necessary by strengthening the fight against vectors, avoiding contact and consumption of organic products from diseased animals and vaccination of animals in areas where the disease is endemic. Furthermore, it is essential to establish management procedures for patients infected with the RVF virus. An appropriately equipped referral hospital is necessary, together with strengthened epidemiological surveillance by notifying all suspected cases of hemorrhagic fevers. © 2015 Elsevier Masson SAS.


Salem M.L.O.,Center Hospitalier National Of Nouakchott | Ghaber S.M.O.,Center Hospitalier National Of Nouakchott | Maouloud M.M.O.,Center Hospitalier National Of Nouakchott | Moctar M.M.,Center Hospitalier National Of Nouakchott
Revue Francophone des Laboratoires | Year: 2011

The present article brings an update about iron metabolism, integrating allmost recent discoveries in this issue. Considerable advances were performed in understanding iron homeostasis, thanks to the study of animal and human models carrying genetic anomalies of the martial metabolism. Among these discoveries, the hepcidin, by highlighting its key role in maintaining iron homeostasis, essential to cell life but also toxic in case of excess. Hepcidin is carrying hopes of many therapies for the treatment of hemochromatosis and anemia of chronic inflammatory diseases. © 2011 - Elsevier Masson SAS - Tous droits réservés.


PubMed | Nouakchott Military Hospital, Service de Chirurgie Orthopedique, Laboratoire Of Biochimie Et Of Biologie Moleculaire and Center Hospitalier National Of Nouakchott
Type: | Journal: Case reports in genetics | Year: 2016

Osteoporosis-pseudoglioma (OPPG) syndrome is a very rare autosomal recessive disorder, caused by mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene. It manifests by severe juvenile osteoporosis with congenital or infancy-onset visual loss. We describe a case of OPPG due to novel mutation in LRP5 gene, occurring in a female Mauritanian child. This 10-year-old female child was born blind, and after then multiple fragility fractures appeared. PCR amplification and sequencing revealed a novel homozygous nonsense mutation in exon 10 of the LRP5 gene (c.2270G>A; pTrP757()); this mutation leads to the production of a truncated protein containing 757 amino acids instead of 1615, located in the third -propeller domain of the LRP5 protein. Both parents were heterozygous for the mutation. This is the first case of the OPPG described in black Africans, which broadens the spectrum of LRP5 gene mutations in OPPG.

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