Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye

Champ-sur-Drac, France

Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye

Champ-sur-Drac, France
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Aubry G.,University of Versailles | Panel P.,Center Hospitalier Intercommunal Of Versailles | Thiollier G.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Huchon C.,University of Versailles | And 3 more authors.
Human Reproduction | Year: 2017

STUDY QUESTION: Which of the Endometriosis Health Profile-5 (EHP-5) and the EuroQol-5D (EQ-5D) is the most efficient to assess quality of life in women suffering from endometriosis? SUMMARY ANSWER: Although EHP-5 and EQ-5D instruments had an excellent responsiveness, EHP-5 has a better discriminative ability than EQ-5 to measure health-related quality of life (HrQoL). WHAT IS KNOWN ALREADY: Proper measurement of HrQoL is important in endometriosis. While many quality of life instruments are available, few have been completely validated in endometriosis. The EHP-5 and the EQ-5D are short and practical scales, which may be useful. Literature is lacking to determine which one is the most suitable in clinical practice or in clinical research. STUDY DESIGN, SIZE, DURATION: This prospective and observational study conducted between 1 January 2012 and 31 December 2013 included a total of 253 consecutive women with proven endometriosis, undergoing medical or surgical treatment, in 2 French tertiary care centers. PARTICIPANTS/MATERIALS, SETTINGS, METHODS: Women over 18 years consulting for painful symptoms of at least 3 months' duration or for infertility, with endometriosis proven histologically or radiologically, were requested to fill in the 2 scales before (T0) and 12 months after treatment (T1). Construct validity consisted in testing presupposed relationships between the scales and the characteristics of the patients or the endometriosis. Responsiveness to change was calculated for all patients and in each treatment group. Effect sizes were used according to Cohen's d method. MAIN RESULTS AND THE ROLE OF CHANCE: A total of 216 women filled in completely all the questionnaires at T0 and 133 (61.6%) at T1. EHP-5 and EQ-5D had good discriminative abilities regarding the patients' symptoms, with significant superiority of EHP-5 concerning three of the nine hypotheses. The largest difference was that calculated for the 'intensity of dysmenorrhea' using the Visual Analogic Scale, with respectively effect size from Cohen's d (ES) = 0.86 95% CI (0.54-1.17) for EHP-5 versus 0.48 95% CI (0.16-0.79) for EQ-5D. There were no differences in EHP-5 or in EQ-5D scores between subgroups according to the characteristics of endometriosis. Overall responsiveness was excellent and equivalent for EHP-5 and for EQ-5D, with, respectively, ES = 0.81 95% CI (0.56-1.56) versus ES = 0.95 95% CI (0.68-1.20). In subgroup analyses, EHP-5 was responsive in case of medical treatment with ES = 0.93 95% CI (0.07-1.70), whereas EQ-5D was not, ES = 0.73 95% CI (-0.06-1.47). LIMITATIONS, REASONS FOR CAUTION: Our study population included patients with symptomatic and mainly severe forms of endometriosis, which may suggest a spectrum bias. The evaluation of responsiveness in case of medical treatment was based on a small number of patients, which limits the interpretation of the difference found between the two scales in this subgroup. WIDER IMPLICATIONS OF THE FINDINGS: EHP-5 is a simple, efficient and valid tool for evaluating quality of life in daily practice and also valuable to provide a primary outcome in clinical studies evaluating treatment efficacy. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.


Gronier H.,University Paris Est Creteil | Swierkowski-Blanchard N.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye
Medecine Therapeutique Medecine de la Reproduction, Gynecologie et Endocrinologie | Year: 2017

Autoimmune pathologies such as thyroid dysfunctions or type 1 diabetes can have an impact on fertility. This article proposes literature data synthesis on the impact of pregnancy on dysthyroidism and type 1 diabetes, preconceptional assessment required and pregnancy management in case of dysthyroidism or type 1 diabetes. Copyright © 2017 John Libbey Eurotext.


Vinson-Bonnet B.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Higuero T.,Clinique Beausoleil | Faucheron J.L.,Grenoble University Hospital Center | Senejoux A.,Center Hospitalier prive Saint Gregoire | And 2 more authors.
International Journal of Colorectal Disease | Year: 2015

Purpose: The aims of this study are to review the advantages and drawbacks of the ambulatory management of patients scheduled for haemorrhoidal surgery and to highlight the reasons for unplanned hospital admission and suggest preventive strategies. Methods: We conducted a systematic review of the literature from January 1999 to January 2013 using MEDLINE and EMBASE databases. Manuscripts were specifically analysed for failure and side effects of haemorrhoidal surgery in ambulatory settings. Results: Fifty relevant studies (6082 patients) were retrieved from the literature review. The rate of ambulatory management failure ranged between 0 and 61 %. The main reasons for failure were urinary retention, postoperative haemorrhage and unsatisfactory pain control. Spinal anaesthesia was associated with the highest rates of urinary retention. Doppler-guided haemorrhoidal artery ligation has less frequent side effects susceptible to impair ambulatory management than haemorrhoidectomy and stapled haemorrhoidopexy. However, the fact that haemorrhoidopexy is less painful than haemorrhoidectomy may allow ambulatory management. Conclusion: Day-case haemorrhoidal surgery can be performed whatever the surgical procedure. Postoperative pain deserves special prevention measures after haemorrhoidectomy, especially by using perineal block or infiltrations. Urinary retention is a common issue that can be responsible for failure; it requires a preventive strategy including short duration spinal anaesthesia. Doppler-guided haemorrhoidal artery ligation is easy to perform in outpatients but deserves more complete evaluation in this setting. © 2014, Springer-Verlag Berlin Heidelberg.


Garbin O.,Hopitaux Universitaires Of Strasbourg | Verdon R.,University of Caen Lower Normandy | Fauconnier A.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye
Journal de Gynecologie Obstetrique et Biologie de la Reproduction | Year: 2012

The antibiotic treatment is indispensable for the treatment of the tubo-ovarian abscesses (TOA). It has to have a wide spectre and would be secondarily adapted in case of a sexually transmitted infection. The surgery remains indicated in first intention in case of vital threat (generalized peritonitis, toxic shock). In the not complicated TOA, the evacuation of abscesses (by draining under imaging or laparoscopy) with the antibiotic treatment gives better rates of cure than the antibiotic treatment alone. For the surgery, several entrys are possible. The laparoscopy allows a shorter hospitalization with fewer complications and a faster resolution of the fever than the laparotomy. The conservative surgery, realized by laparoscopy, has hight rates of successes with few complications. The radical surgery, by coelioscopy or by laparotomy, has high rates of complications. Transvaginal ultrasound guided aspiration is an alternative in the drainage by laparscopy with identical succes. It has been well evaluated. It has low morbidity and can be proposed in first intention in not complicated TOA. © 2012 Elsevier Masson SAS. All rights reserved.


PubMed | Agilent Technologies, University of Health Sciences and Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye
Type: Journal Article | Journal: European journal of medical genetics | Year: 2016

Microdeletion and microduplication syndromes are well-known causes of developmental delay and/or malformations of differing severity. It was recently reported that a microdeletion at the 3q13.31 locus is associated with a new syndrome combining developmental delay, postnatal overgrowth and dysmorphic features. However, the reciprocal microduplication has only been described in a few case reports displaying some clinical features of the microdeletion syndrome. Here, we report on a female infant with a 3.34Mb microduplication of the 3q13.2q13.31 region inherited from her mother. The infant presented with severe intellectual disability, learning difficulties, intrauterine and postnatal growth retardation and skeletal particularities but no dysmorphic traits. This microduplication encompassed the previously described shortest region of overlap, which contains five genes (DRD3, ZNF80, TIGIT, MIR568 and ZBTB20). We reviewed the phenotypes described in the literature on microduplications and in the well-characterized 3q13.31 microdeletion syndrome. In agreement with the literature data, DRD3 and ZBTB20 appear to be strong candidate genes for neurodevelopmental defects and growth retardation. Lastly, we consider the putative mechanism of this rearrangement, which may involve a particular kind of nonallelic homologous recombination of human endogenous retrovirus elements.


Ben Azoun M.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Tatencloux S.,Service de neuropediatrie | Deiva K.,Service de neuropediatrie | Blanc P.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye
Archives de Pediatrie | Year: 2014

Although less frequent than viral encephalitis, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a frequent form of acute pediatric encephalitis. After a prodromal phase of flu-like symptoms, psychiatric symptoms predominate-agitation, anxiety, hallucinations-and can make correct diagnosis more difficult. Also noted are abnormal dyskinesia and dystonia-like movements, partial seizures, difficulties talking or memorizing, and autonomic manifestations. The presentation of two cases of anti-NMDAR encephalitis illustrates the symptoms of this disease. Although the CSF abnormalities are not highly specific of this disease, and MRI most often normal, EEG shows more specific signs. These observations enable us to discuss different treatment options and understand the progression of this disease. © 2014 Elsevier Masson SAS.


Pizzoferrato A.-C.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Bui C.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Fauconnier A.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Bader G.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye
Gynecologie Obstetrique Fertilite | Year: 2013

Pelvic organ prolapse is a common pelvic floor disorder in postmenopausal women. The literature is quite poor concerning the management of prolapse during pregnancy in young women. We report the case of a 39-year-old multiparous woman referred for the treatment of an exteriorized uterine prolapse at 13 weeks of gestation. The management of cervical prolapse depends on its stage, its evolution and on gestational age. It combines local antiseptics, rest and manual reintegration or reduction of the prolapsus using a pessary to prevent ulceration of the cervix. In case of stage IV (POP-Q) uterine prolapse, vaginal delivery may be compromised. No recommendation is actually available about route of delivery in case of exteriorized uterine prolapse. It should be clearly discussed regarding the potential risk of cesarean section for dystocia. Surgical repair of the prolapse will be discussed after childbirth according to functional impairment and women's desire for pregnancy. © 2013 Elsevier Masson SAS. All rights reserved.


Huchon C.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Huchon C.,University of Versailles | Fauconnier A.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Fauconnier A.,University of Versailles
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2010

This review of the literature focuses on the diagnosis and surgical management of adnexal torsion. Diagnosis of adnexal torsion is difficult and is based on a range of elements obtained by questioning, clinical examination and additional investigations. Pelvic and Doppler ultrasonography are often incapable of revealing this pathology. When adnexal torsion is suspected and diagnosis can only be achieved by surgery, arrangements should be made for laparoscopy as soon as possible. Treatment consists essentially of untwisting the adnexa, even when necrosed, and completed as required by treatment of any cyst present and/or ligamentopexy. © 2010 Elsevier Ireland Ltd. All rights reserved.


Crosnier H.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Tubiana-Rufi N.,Service dendocrinologie et de diabetologie pediatrique
Archives de Pediatrie | Year: 2013

There is an increase in the incidence of type 1 diabetes (T1D) in children younger than 5 years of age and continuous subcutaneous insulin infusion (CSII) appears to be an increasingly popular therapeutic option in France. A retrospective self-evaluation questionnaire was distributed to parents of young children with T1D treated by CSII (42 children, age 4.8±1.0 years, 2.3±0.5 years at the onset of TD1, mean± SD). It focused on the quality of diabetes management in daycare centers or with nannies and at school. Parental satisfaction related to the management of their children was overall good (84% for all the parents, 70.5% for the parents of children at nursery-school, from 3 to 6 years. However 93% of the parents experienced and overcame serious difficulties: exclusion of the children on account of DT1 (school trips, daycare centers after school), use of the pump for lunch and snacks, realization of glycemic controls, participation in school trips, survey during school meals. In spite of these difficulties these young children had a normal and safe time at school. The management of the young children with DT1, treated by CSII, in alternate care centers and at school need to be improved; the experience was positive when daycare workers and teachers agreed to be instructed. © 2013 Elsevier Masson SAS.


Huchon C.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | Huchon C.,French Institute of Health and Medical Research | Huchon C.,University of Paris Descartes | Staraci S.,Center Hospitalier Intercommunal Of Poissy Saint Germain En Laye | And 3 more authors.
Human Reproduction | Year: 2010

Background: Adnexal torsion (AT) is difficult to diagnose and requires immediate surgery. The aim of this study was to develop a simple score for assisting in the pre-operative diagnosis of AT in women with acute pelvic pain. Methods: Using data from a retrospective cohort of 142 patients with acute pelvic pain, we developed a score based on multiple logistic regression after a jackknife procedure. We validated the score in a prospective cohort of 35 women with acute pelvic pain. Results:Five criteria were independently associated with AT confirmed by surgery: unilateral lumbar or abdominal pain [adjusted odds ratio (aOR), 4.1; 95 confidence interval (95 CI), 1.2-14.0]; pain duration <8 h at first presentation (aOR, 8.0; 95 CI, 1.7-37.5), vomiting (aOR, 7.9; 95 CI, 2.3-27.0), absence of leucorrhoea and metrorrhagia (aOR, 12.6; 95 CI, 2.3-67.6) and ovarian cyst larger than 5 cm by ultrasonography (aOR, 10.6; 95 CI, 2.9-38.8). The torsion score was based on these five criteria. Low-risk and high-risk groups were derived from values of the score [probability of AT, 3.7 (95 CI, 0-7.8) and 69 (95 CI, 53-84), respectively]. Application of these criteria to the prospective cohort confirmed the diagnostic accuracy of the score [probability of AT, 0 (95 CI, 0-16) and 75 (95 CI, 26-100) in the low-risk and high-risk groups, respectively]. Conclusions: This easy-to-calculate score may prove useful for diagnosing AT in patients with acute pelvic pain seen at general or gynaecology emergency departments. © 2010 The Author.

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