Center Hospitalier Guillaume Regnier

Rennes, France

Center Hospitalier Guillaume Regnier

Rennes, France
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Le Dare B.,University of Rennes 1 | Jehannin A.,University of Rennes 1 | Lanoe F.,University of Rennes 1 | Philippe F.,University of Rennes 1 | And 3 more authors.
Annales Pharmaceutiques Francaises | Year: 2015

In France, the Court can issue a medical treatment order only for criminally responsible persons. The nature of the treatment to be administered is at the discretion of the physician in charge of the sexual offender's care. Treatment management of sexual offenders relies essentially on psychotherapy, and preferentially cognitive behavioral therapy. For mostsevere sexual offenders, drug treatments, including hormonal treatment and selective serotoninreuptake inhibitors, are used to complement psychotherapy. This literature review aims atsynthesizing practice changes in the treatment management of sexual offenders. © 2015 Elsevier Masson SAS.


Slimano F.,University of Paris Descartes | Slimano F.,Center hospitalier Manchester | Gervais F.,University of Paris Descartes | Masse C.,University of Paris Descartes | And 3 more authors.
Annales Pharmaceutiques Francaises | Year: 2014

The current format of French residency in hospital pharmacy was created in 1983 and is a 4-year specialized training. So far, training has not been recognized as a prerequisite for hospital pharmacy practice. Since 2011, pharmacy residents and hospital pharmacists representative structures have lobbied for that recognition and the government has worked in that direction. The ideology of the concept was validated after a period of probation and the regulatory procedure began late 2012. Two key elements were initially identified as obstacles: first the European legislation on recognition of professional qualifications and then the fear that there might not be enough hospital pharmacists trained in order to complete the care missions in hospital pharmacies in France. The European legislation has now been amended in order to recognize professional qualifications and a demographic analysis of hospital pharmacists leads to the conclusion that these items are no longer obstacles. In 2014, hospital pharmacy residency, through the Specialized Studies degree, should be recognized as a prerequisite for hospital pharmacy practice. © 2014 Elsevier Masson SAS.


Le Sourn-Bissaoui S.,University of Rennes 2 – Upper Brittany | Aguert M.,University of Caen Lower Normandy | Girard P.,University of Rennes 2 – Upper Brittany | Chevreuil C.,Center Hospitalier Guillaume Regnier | Laval V.,University of Poitiers
Journal of Communication Disorders | Year: 2013

We examined the understanding of emotional speech by children and adolescents with autism spectrum disorders (ASD). We predicted that they would have difficulty understanding emotional speech, not because of an emotional prosody processing impairment but because of problems drawing appropriate inferences, especially in multiple-cue environments. Twenty-six children and adolescents with ASD and 26 typically developing controls performed a computerized task featuring emotional prosody, either embedded in a discrepant context or without any context at all. They must identify the speaker's feeling. When the prosody was the sole cue, participants with ASD performed just as well as controls, relying on this cue to infer the speaker's intention. When the prosody was embedded in a discrepant context, both ASD and TD participants exhibited a contextual bias and a negativity bias. However ASD participants relied less on the emotional prosody than the controls when it was positive. We discuss these findings with respect to executive function and intermodal processing. Learning outcomes: After reading this article, the reader should be able to (1) describe the ASD participants pragmatic impairments, (2) explain why ASD participants did not have an emotional prosody processing impairment, and (3) explain why ASD participants had difficulty inferring the speaker's intention from emotional prosody in a discrepant situation. © 2013 Elsevier Inc.


PubMed | Center Hospitalier Guillaume Regnier, French Institute of Health and Medical Research, University of Rennes 1, University Paris - Sud and Rennes University Hospital Center
Type: Journal Article | Journal: Acta psychiatrica Scandinavica | Year: 2016

We aimed to explore whether the prevalence of manic switch was underestimated in randomized controlled trials (RCTs) compared to observational studies (OSs).Meta-analyses and simple and systematic reviews were identified by two reviewers in a blinded, standardized manner. All relevant references were extracted to include RCTs and OSs that provided data about manic switch prevalence after antidepressant treatment for a major depressive episode. The primary outcome was manic switch prevalence in the different arms of each study. A meta-regression was conducted to quantify the impact of certain variables on manic switch prevalence.A total of 57 papers (35 RCTs and 22 OSs) were included in the main analysis. RCTs underestimated the rate of manic switch [0.53 (0.32-0.87)]. Overestimated prevalence was related to imipraminics [1.85 (1.22-2.79)]; to serotonin-norepinephrine reuptake inhibitors [1.74 (1.06-2.86)]; and to other classes of drugs [1.58 (1.08-2.31)], compared to placebo treatment. The prevalence of manic switch was lower among adults than among children [0.2 (0.07-0.59)]; and higher [20.58 (8.41-50.31)] in case of bipolar disorder.Our results highlight an underestimation of the rates of manic switch under antidepressants in RCTs compared to the rates observed in observational studies.


Gerbes A.,University of Rennes 1 | Leroy H.,Center Medical Louis Guilloux | Leferrand P.,Center Hospitalier Guillaume Regnier | Michel D.,Center Medical Louis Guilloux | And 2 more authors.
Information Psychiatrique | Year: 2015

The mental health of precarious migrants is a very frequent reason for consultation, and little is known by health professionals. A retrospective study was conducted from 2010 to 2013 in 110 patients by the Mobile Psychiatry and Insecurity Team at a specialized medical centre equipped to deal with migrants in Rennes. The average age was 29 years, 55% were homeless, 70% seeking asylum, and 76% had experienced violence. Diagnoses were: posttraumatic stress (27%), psychosocial distress (21%), anxiety-depressive syndrome (18%). 67% were lost to follow-up with a median duration of 3.5 months, mainly unaccompanied minors and people in psycho-social distress. Mental disorders that were not obvious or not recognized relieves the care management of specific individuals who are professionally trained to improve patient adherence. © 2015, John Libbey Eurotext. All rights reserved.


PubMed | Center hospitalier Guillaume Regnier, University of Rennes 1 and Rennes University Hospital Center
Type: Journal Article | Journal: Annales pharmaceutiques francaises | Year: 2015

In France, the Court can issue a medical treatment order only for criminally responsible persons. The nature of the treatment to be administered is at the discretion of the physician in charge of the sexual offenders care. Treatment management of sexual offenders relies essentially on psychotherapy, and preferentially cognitive behavioral therapy. For most severe sexual offenders, drug treatments, including hormonal treatment and selective serotonin reuptake inhibitors, are used to complement psychotherapy. This literature review aims at synthesizing practice changes in the treatment management of sexual offenders.


PubMed | Center Hospitalier Guillaume Regnier, French Institute of Health and Medical Research and University of Rennes 1
Type: | Journal: Journal of psychiatric research | Year: 2016

There is a long-standing and very active debate regarding which psychotherapeutic intervention should be used in depressive disorders. However, the effects of psychotherapies may result majorly from non-specific factors rather than from specific factors related to the type of psychotherapeutic intervention. We performed a systematic review and meta-analysis on aggregated data to understand how the effects of different psychotherapies are impacted by non-specific factors. We included randomized controlled trials that assessed the efficacy of psychotherapeutic interventions in the treatment of adult depressive disorders. The primary outcome was the change in depression score from baseline to the latest follow-up visit (i.e. response). A meta-regression was performed to predict response according to the type of intervention and non-specific factors (e.g. number of treatment sessions, length of follow-up, therapeutic allegiance of the investigator). The main analysis included 214 study arms from 84 trials. The effects of psychotherapies compared to the waiting list control condition failed to remain significant after adjusting for non-specific factors. Response increased with the number of treatment sessions (=0.03, 95% CI [0.01; 0.04]) and the length of follow-up (=0.01, 95% CI [0.00; 0.02]). Response also improved in case of presumed therapeutic allegiances among investigators (=0.29, 95% CI [0.07; 0.52]). Response to psychotherapies seems to be closely related to non-specific effects. The development of a well-designed trial that controls for non-specific factors might help disentangle the effects of psychotherapies.


Guignard J.-H.,Center Hospitalier Guillaume Regnier | Guignard J.-H.,University of Paris Descartes | Jacquet A.-Y.,University of Paris Descartes | Lubart T.I.,University of Paris Descartes
PLoS ONE | Year: 2012

Numerous authors reported a prevalence of perfectionism in gifted populations. In addition, an unhealthy form of perfectionism that leads to anxiety disorder has been described. Using self-report measures (CAPS and R-CMAS) with 132 children, we hypothesized that intellectually gifted children express a higher level of perfectionism and anxiety. Our results pointed out a paradox: the gifted group obtained a higher self-oriented perfectionism score than the control group in 6th grade, but present the same level of anxiety. In contrast, the gifted group showed the same level of perfectionism than non-gifted 5th graders, but reported a higher anxiety level. Thus, the interplay between perfectionism and anxiety appears to be more complex than a simple linear relationship in giftedness. © 2012 Guignard et al.


Djadaoudjee L.,Center Hospitalier Guillaume Regnier
Revue de l'Infirmiere | Year: 2013

French cultural diversity is evident within French hospitals, where nurses are confronted with communication problems resultingfrom the language barrier. While communication is indeed essential, there is another important aspect of caring for a patient for behind the language barrier lies a cultural barrier which must be taken into account in order to provide high-quality care © 2013 Elsevier Masson SAS. All rights reserved.


PubMed | Center hospitalier Guillaume Regnier
Type: | Journal: Revue de l'infirmiere | Year: 2013

French cultural diversity is evident within French hospitals, where nurses are confronted with communication problems resulting from the language barrier. While communication is indeed essential, there is another important aspect of caring for a patient for behind the language barrier lies a cultural barrier which must be taken into account in order to provide high-quality care.

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