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Yang G.,Center for Tumor Treatment | Yang G.,Binzhou Medical College | Wang Y.,Center for Tumor Treatment | Wang Y.,Binzhou Medical College | And 2 more authors.
Oncology Letters | Year: 2013

Brain metastasis is a significant cause of morbidity and mortality and a critical complication of non-central nervous system primary carcinoma. The present study describes the clinical case of a 46-year-old male with lung cancer and life-threatening brain metastases. The patient was diagnosed with lung cancer with a clinical stage of T2N0M1 (stage IV). Six months after the initial diagnosis and administration of conformal radiotherapy combined with three cycles of chemotherapy, an enhanced computed tomography (CT) scan of the brain revealed abnormalities with double-dosing of intravenous contrast. The CT scan identified >24 lesions scattered in the whole brain. The patient was treated with three-fraction Cyberknife radiotherapy at 22 Gy, delivered to the brain metastases at the Center for Tumor Treatment of People's Liberation Army 107th Hospital. Following CyberKnife therapy, a CT scan of the brain revealed that most of the tumors had disappeared with almost no residual traces. The stereotactic radiosurgery (SRS) conducted using CyberKnife, an image-guided frameless robotic technology for whole-body radiosurgery, had produced a marked response. The present case report demonstrates that CyberKnife therapy plays a significant role in the management of multiple metastatic brain tumors. Source


Yang G.,Center for Tumor Treatment | Yang G.,Binzhou Medical College | Li M.,Center for Tumor Treatment | Wang Y.,Center for Tumor Treatment | And 2 more authors.
Experimental and Therapeutic Medicine | Year: 2013

Stereotactic body radiation therapy (SBRT) plays an important role in the treatment of early stage non-small cell lung cancer (NSCLC), particularly when patients are unable to tolerate surgical resection due to comorbid conditions or are unwilling to undergo surgery. High rates of local tumor control that may rival the results of surgery have been demonstrated in certain cases with the practical advantage of a short course of treatment and acceptable toxicity. However, there are few reports of a marked change in the complete response of high risk lung cancer with more than ten lesions. In the present study, we report a case of adenocarcinoma of the lung with 15 lesions which had metastasized to the mediastinal lymph nodes. Due to advanced age, multiple lesions and metastasis to the mediastinal lymph nodes and the hilar region of the lung, the patient was treated using CyberKnife. A marked response was noted 42 days after CyberKnife radiosurgery with complete disappearance of the tumor and metastasticlesions. Source


Yang G.,Binzhou Medical College | Liu X.,Binzhou Medical College | Lin T.,Center for Tumor Treatment | Sun D.,Binzhou Medical College | And 3 more authors.
WIT Transactions on Biomedicine and Health | Year: 2014

Objective: We sought to explore the effect of black garlic extract on lung cancer cell line Lewis and preliminary discuss the possible molecular mechanism. Methods: Inhibition rate of lung cancer was detected by MTT. Changes of cell morphology were observed by Hoechst staining. Flow cytometry is used to detect changes in the cell cycle. The activity of caspase-3 and caspase-9 was assayed by colorimetry with commercial kit. Results: Black garlic extract could had significantly inhibitory action on growth of Lewis lung cancer cell. Black garlic extract could significantly induced Lewis cell apoptosis and affected cell cycle. The activities of caspase-3 and caspase-9 were significantly increased by black garlic extract. Conclusions: Black garlic extract suppresses the growth of lung cancer Lewis cells. Black garlic extract induces apoptosis of Lewis cells, which may be associated with enhanced caspase-3 and caspase-9 activity. © 2014 WIT Press. Source


Wang Y.,Center for Tumor Treatment | Wang Y.,Binzhou Medical College | Wan L.,Binzhou Medical College | Lin T.,Center for Tumor Treatment | And 3 more authors.
WIT Transactions on Biomedicine and Health | Year: 2014

We sought to explore the effects on tumor growth and immunoregulation with H22 by black garlic extract. The tumor-bearing C57BL/6 mouse model was established, 40 mice were randomized into four groups: control group (peritoneal injection 0.9%NS, 0.2 mL), low dose black garlic group (20 mg/mL), middledose black garlic group (50mg/mL), high dose black garlic group (100 mg/mL). After 2 weeks, mice were sacrificed, and then the tumors were separated and weighed to calculate the tumor-inhibiting rate. Flow cytometry Annexin V-FITC/PI was used to detect tumor cell apoptosis. The lymphocyte transformation rate and NK cell killing activity were tested. Black garlic extract significantly increases the tumor-inhibiting rate and induced H22 cell apoptosis, black garlic extract significantly improved the lymphocyte transformation rate and NK killing activity. Black garlic extract can obviously increase the tumor-inhibiting rate of H22 mice and induced H22 cell apoptosis. It also proved to be associated with immunoregulation. © 2014 WIT Press. Source


Lin S.,Center for Tumor Treatment | Lin S.,Binzhou Medical College | Yang G.,Binzhou Medical College | Wan L.,Binzhou Medical College | And 5 more authors.
WIT Transactions on Biomedicine and Health | Year: 2014

Objective: We sought to explore the inhibitory effect on tumor growth and observe the effect on the expression of bax, bcl-2, caspase-9 from H22 xenotransplanted tumors of black garlic extract. Methods: Four groups of transplanted tumor models were treated with 0.9% NS, low dose black garlic extract (20 mg/mL), middle dose black garlic extract (50 mg/mL), and high dose black garlic extract (100 mg/mL). After two weeks, mice were sacrificed, and then the tumors were separated and weighed to calculate the tumor-inhibiting rate. Immunohistochemistry was used to detect expression of bax protein and real-time PCR was used to detect the expression of bcl-2, caspase-9. Results: Black garlic extract could markedly inhibit the growth of H22 xenotransplanted tumors, with an inhibiting rate of 42.3%. Bax protein expression increased, bcl-2 mRNA expression decreased and caspase-9mRNA expression increased relatively. Conclusions: Black garlic extract can obviously inhibit the tumor growth of H22 mice xenotransplanted tumors, increase the expression of bax protein and caspase-9 mRNA and decrease the expression of bcl-2mRNA in transplanted tumor. © 2014 WIT Press. Source

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