Center for the Study of Environmental Cancer

Monfalcone, Italy

Center for the Study of Environmental Cancer

Monfalcone, Italy
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Bianchi C.,Center for the Study of Environmental Cancer | Bianchi T.,Center for the Study of Environmental Cancer
European Journal of Oncology | Year: 2016

Summary. A 42-year-old man was diagnosed with a Bcell, centroblastic, follicular non-Hodgkin lymphoma of the liver in 1992. He had worked as carpenter and shipwright in various firms and as a fitter at the Monfalcone shipyards. Partial hepatectomy and chemotherapy were performed. The patient remained symptom-free for 14 years. In 2006 lymphoma recurred with involvment of left subpleural tissue, some ribs, abdominal and pelvic lymphnodes. Chemotherapy resulted in a transitory improvement. The patient died in 2008. In this case, occupational history indicates that the patient had heavily exposed to asbestos. Asbestos, as an agent inducing immune impairment, plausibly played a major role in the development of liver lymphoma as well as in the recurrence of the disease. © Mattioli 1885.


Magnani C.,University of Eastern Piedmont and Piemonte | Magnani C.,University of Turin | Bianchi C.,Center for the Study of Environmental Cancer | Chellini E.,Unit of Environmental and Occupational Epidemiology. ISPO | And 18 more authors.
Medicina del Lavoro | Year: 2015

The III Italian Consensus Conference on Pleural Mesothelioma (MM) convened on January 29th 2015. This report presents the conclusions of the 'Epidemiology, Public Health and Occupational Medicine' section. MM incidence in 2011 in Italy was 3.64 per 100,000 person/years in men and 1.32 in women. Incidence trends are starting to level off. Ten percent of cases are due to non-occupational exposure. Incidence among women is very high in Italy, because of both non-occupational and occupational exposure. The removal of asbestos in place is proceeding slowly, with remaining exposure. Recent literature confirms the causal role of chrysotile. Fibrous fluoro-edenite was classified as carcinogenic by IARC (Group 1) on the basis of MM data. A specific type (MWCNT-7) of Carbon Nanotubes was classified 2B. For pleural MM, after about 45 years since first exposure, the incidence trend slowed down; with more studies needed. Cumulative exposure is a proxy of the relevant exposure, but does not allow to distinguish if duration or intensity may possibly play a prominent role, neither to evaluate the temporal sequence of exposures. Studies showed that duration and intensity are independent determinants of MM. Blood related MM are less than 2.5%. The role of BAP1 germline mutations is limited to the BAP1 cancer syndrome, but negligible for sporadic cases. Correct MM diagnosis is baseline; guidelines agree on the importance of the tumor gross appearance and of the hematoxylin-eosin-based histology. Immunohistochemical markers contribute to diagnostic confirmation: the selection depends on morphology, location, and differential diagnosis. The WG suggested that 1) General Cancer Registries and ReNaM Regional Operational Centres (COR) interact and systematically compare MM cases; 2) ReNaM should report results presenting the diagnostic certainty codes and the diagnostic basis, separately; 3) General Cancer Registries and COR should interact with pathologists to assure the up-To-date methodology; 4) Necroscopy should be practiced for validation. Expert referral centres could contribute to the definition of uncertain cases. Health surveillance should aim to all asbestos effects. No diagnostic test is recommended for MM screening. Health surveillance should provide information on risks, medical perspective, and smoking cessation. The economic burden associated to MM was estimated in 250,000 Euro per case.


Bianchi C.,Center for the Study of Environmental Cancer | Bianchi T.,Center for the Study of Environmental Cancer
Indian Journal of Occupational and Environmental Medicine | Year: 2012

Background: The high mesothelioma incidence in Monfalcone, Italy, is mainly attributable to shipbuilding activity. Mesothelioma risk among shipyard workers in Monfalcone is poorly defined. Materials and Methods: Workers hired at the Monfalcone shipyards in the period 1950-1959 were identified by surveying shipyard roll. The list of the workers was coupled with the archive data of Monfalcone and Trieste Hospitals. Mesotheliomas diagnosed in the above people were reexamined. Results: Of 1,403 workers hired in 1950-1959, 35 were diagnosed with mesothelioma (34 pleural, one peritoneal) between 1978 and 2012. Latency periods exceeded 40 years in 31 cases. The highest percentage of mesotheliomas was observed among people aged 14-19 years at hiring time (3.4%). Four mesothelioma patients had a blood relative with the same tumor. Conclusions: The present findings show high mesothelioma percentage among shipyard workers hired at young ages. The effects of asbestos exposure begun in 1950-1959 cannot be considered as exhausted.


PubMed | Center for the Study of Environmental Cancer
Type: Journal Article | Journal: Indian journal of occupational and environmental medicine | Year: 2012

The Monfalcone area, northeastern Italy, a small industrial district with large shipyards, shows a high incidence of asbestos-related mesothelioma. In order to reconstruct some features of the Monfalcone shipbuilding activity during World War II and its health effects, the shipyard roll were examined, and people hired in 1942 were identified. The list of 2,776 persons hired in 1942 was coupled with the Pathological Anatomy Units archives of the Monfalcone and the Trieste Hospitals. Eighteen of the above persons had been diagnosed with pleural mesothelioma in the period 1981-2005. Eight patients had their first exposure in 1942, and the others had histories of previous exposures. Of 557 persons aged 14-15 years in 1942, six had a diagnosis of pleural mesothelioma. Necropsy findings were available in 14 cases. The burdens of lung asbestos bodies, isolated in 11 cases, showed wide variation (from 150 to 600,000 bodies per gram of dried tissue). While probably underestimated, the present data indicate a high incidence of mesothelioma among the shipyard workers of Monfalcone.


PubMed | Center for the Study of Environmental Cancer
Type: Journal Article | Journal: Indian journal of occupational and environmental medicine | Year: 2013

The high mesothelioma incidence in Monfalcone, Italy, is mainly attributable to shipbuilding activity. Mesothelioma risk among shipyard workers in Monfalcone is poorly defined.Workers hired at the Monfalcone shipyards in the period 1950-1959 were identified by surveying shipyard roll. The list of the workers was coupled with the archive data of Monfalcone and Trieste Hospitals. Mesotheliomas diagnosed in the above people were reexamined.Of 1,403 workers hired in 1950-1959, 35 were diagnosed with mesothelioma (34 pleural, one peritoneal) between 1978 and 2012. Latency periods exceeded 40 years in 31 cases. The highest percentage of mesotheliomas was observed among people aged 14-19 years at hiring time (3.4%). Four mesothelioma patients had a blood relative with the same tumor.The present findings show high mesothelioma percentage among shipyard workers hired at young ages. The effects of asbestos exposure begun in 1950-1959 cannot be considered as exhausted.

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