Center for Strategic Information in Health Surveillance

Brazil

Center for Strategic Information in Health Surveillance

Brazil

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Iser B.P.M.,Center for Strategic Information in Health Surveillance | Lima H.C.A.V.,Center for Strategic Information in Health Surveillance | De Moraes C.,Center for Strategic Information in Health Surveillance | De Moraes C.,Secretariat of Health Surveillance | And 8 more authors.
Epidemiology and Infection | Year: 2012

An outbreak of meningococcal disease (MD) with severe morbidity and mortality was investigated in midwestern Brazil in order to identify control measures. A MD case was defined as isolation of Neisseria meningitidis, or detection of polysaccharide antigen in a sterile site, or presence of clinical purpura fulminans, or an epidemiological link with a laboratory-confirmed case-patient, between June and August 2008. In 8 out of 16 MD cases studied, serogroup C ST103 complex was identified. Five (31%) cases had neurological findings and five (31%) died. The attack rate was 12 cases/100 000 town residents and 60 cases/100 000 employees in a large local food-processing plant. We conducted a matched case-control study of eight primary laboratory-confirmed cases (1:4). Factors associated with illness in single variable analysis were work at the processing plant [matched odds ratio (mOR) 22, 95% confidence interval (CI) 23-2077, P<001], and residing <1 year in Rio Verde (mOR 7, 95% CI 111-439, P<002). Mass vaccination (>10 000 plant employees) stopped propagation in the plant, but not in the larger community. © Copyright Cambridge University Press 2011.


PubMed | Center for Strategic Information in Health Surveillance
Type: Journal Article | Journal: Epidemiology and infection | Year: 2012

SUMMARYAn outbreak of meningococcal disease (MD) with severe morbidity and mortality was investigated in midwestern Brazil in order to identify control measures. A MD case was defined as isolation of Neisseria meningitidis, or detection of polysaccharide antigen in a sterile site, or presence of clinical purpura fulminans, or an epidemiological link with a laboratory-confirmed case-patient, between June and August 2008. In 8 out of 16 MD cases studied, serogroup C ST103 complex was identified. Five (31%) cases had neurological findings and five (31%) died. The attack rate was 12 cases/100 000 town residents and 60 cases/100 000 employees in a large local food-processing plant. We conducted a matched case-control study of eight primary laboratory-confirmed cases (1:4). Factors associated with illness in single variable analysis were work at the processing plant [matched odds ratio (mOR) 22, 95% confidence interval (CI) 23-2077, P<001], and residing <1 year in Rio Verde (mOR 7, 95% CI 111-439, P<002). Mass vaccination (>10 000 plant employees) stopped propagation in the plant, but not in the larger community.

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