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Herbert K.M.,Center for Scientific Research and Higher Education | Pimienta G.,Center for Scientific Research and Higher Education at Ensenada
mBio | Year: 2016

The Epstein-Barr virus (EBV)-encoded noncoding RNAs EBER1 and EBER2 are highly abundant through all four latency stages of EBV infection (III-II-I-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. In vivo, EBV-infected B cells derived from freshly isolated lymphocytes show that EBER1/2 deletion does not impair viral latency. Based on published quantitative proteomics data from BJAB cells expressing EBER1 and EBER2, we propose that the EBERs, through their activation of AKT in a B-cell-specific manner, are a functionally redundant backup of latent membrane protein 1 (LMP1)—an essential oncoprotein in EBV-associated malignancies, with a main role in AKT activation. Our proposed model may explain the lack of effect on viral latency establishment in EBER-minus EBV infection. © 2016 Herbert and Pimienta.


Du Z.,Tsinghua University | Yahyapour R.,University of Gottingen | He Y.,Microsoft | Koziris N.,National Technical University of Athens | And 4 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Despite significant effort parallel and distributed systems available today are still not fully utilized and exploited. Scheduling and load balancing techniques remain crucial for implementing efficient parallel and distributed applications and for making best use of existing parallel and distributed systems. The need for such techniques intensifies with the foreseen advent of exa-scale computer systems with many core and accelerator architectures. Similarly, cloud computing became a viable paradigm for some applications. Scheduling includes planning and optimization of the resource allocation as well as coping with the dynamics of the systems. These topics have been subject for research for many decades but remain one of the core topics in parallel and distributed computing. © 2013 Springer-Verlag.


Favela J.,Center for Scientific Research and Higher Education | Kaye J.,Oregon Health And Science University | Skubic M.,University of Missouri | Rantz M.,University of Missouri | Tentori M.,Center for Scientific Research and Higher Education
IEEE Pervasive Computing | Year: 2015

Living laboratories are real-life settings with embedded heterogeneous technology, where subjects can conduct their everyday activities while researchers measure and observe their interactions with pervasive technology. Early examples of living labs for pervasive healthcare research include home environments with sensing and control infrastructure, such as the Aware Home at Georgia Tech and the PlaceLab at MIT. These labs offer realistic conditions but aren't actual living spaces. Here, the authors focus on actual living spaces that have been instrumented to design and evaluate pervasive healthcare systems and applications: The Life Laboratory at the Oregon Center for Aging & Technology (ORCATECH); TigerPlace, a senior housing facility in Missouri; and Life at a Pie (Living at a Pervasive Interaction Environment) in Tijuana, Mexico. © 2002-2012 IEEE.


Tentori M.,Center for Scientific Research and Higher Education | Escobedo L.,Technological Institute of Tijuana | Balderas G.,Fundacion Pasitos
IEEE Pervasive Computing | Year: 2015

Deploying pervasive technology in 'the wild' isn't trivial; it's even more challenging if it's intended for long-term use in challenging environments. Over the past five years, the authors have been designing, developing, and pilot-testing pervasive technology to support several dimensions of the therapy cycle of children with autism, including augmented reality to support cognition, ambient displays to encourage positive behaviors, and exergames to support motor development. They have gradually deployed a range of technologies in a school clinic, where 15 physiologist-teachers serve nearly 60 children with autism. Their effort is showing how smart environments can positively impact current therapeutic practices. In this article, the authors reflect on their experiences creating this smart environment. They also discuss their deployment process and demonstrate that their smart environment is easy to use, useful, supports sustained empirical measurement and iterative development, and offers numerous educational and therapeutic benefits for children with autism. They close with a discussion of potential application themes as future work. This article is part of a special issue on smart spaces. © 2002-2012 IEEE.


Escobedo L.,Autonomous University of Baja California | Tentori M.,Center for Scientific Research and Higher Education | Quintana E.,Center for Scientific Research and Higher Education | Favela J.,Center for Scientific Research and Higher Education | Garcia-Rosas D.,Center for Scientific Research and Higher Education
IEEE Pervasive Computing | Year: 2014

Children with autism have difficulty sustaining their selective attention during therapy sessions. Attention management techniques involve the use of verbal and visual prompting, annotated on top of the physical objects used during therapies. Here, the authors explore how augmented reality helps integrate the physical and digital worlds, mimicking current strategies for attention management in autism. They describe their design decisions when developing the Mobile Object Identification System (Mobis), a mobile augmented reality application that lets teachers superimpose digital content on top of physical objects. The results of a five-week deployment study demonstrate that Mobis is useful and easy to use, increases the sustained and selective attention of children with autism, and elicits positive emotions during therapies. This article is part of a special issue on managing attention. © 2002-2012 IEEE.


Ringland K.E.,University of California at Irvine | Escobedo L.,Autonomous University of Baja California | Zalapa R.,Center for Scientific Research and Higher Education | Tentori M.,Center for Scientific Research and Higher Education | And 2 more authors.
Conference on Human Factors in Computing Systems - Proceedings | Year: 2014

Natural User Interfaces (NUI) offer an innovative approach to sensory integration therapies. We designed and developed SensoryPaint, a NUI with the capability of superimposing the user's reflection on a projected surface and "painting" this surface with balls of different textures and colors. We conducted a preliminary lab-based evaluation with 15 children with neurodevelopmental disorders in which they used the system for one hour. Our results demonstrate that whole-body interactions, such as those used in SensoryPaint, are promising as therapeutic tools for children with neurodevelopmental disorders.


Rodriguez-Sanz L.,Autonomous University of Barcelona | Mortyn P.G.,Autonomous University of Barcelona | Herguera J.C.,Center for Scientific Research and Higher Education | Herguera J.C.,Catalan Institution for Research and Advanced Studies | Zahn R.,Autonomous University of Barcelona
Paleoceanography | Year: 2013

Fine-scale, paired Mg/Ca-δ18O profiles (Globigerinoides ruber white, sensu lato) from the San Lázaro Basin (SLB) at 25°N in the Northeast Pacific reveal a transition from a predominant presence of tropical/subtropical waters during the last glacial termination (T1) to an increasing influence of fresh and cold California Current waters toward the Holocene. Changing atmospheric circulation patterns over the Northeast Pacific in step with the demise of the Northern Hemisphere ice sheets and/or with a shift from El Niño- to La Niña-like conditions toward the Holocene are prime candidates to explain this water mass change. δ 18OSW-IVC increases of ~0.5-0.7‰ during the Younger Dryas (YD) and Heinrich stadial 1 (HS1) at the SLB are observed in a number of δ18OSW-IVC records from the tropical Pacific, more directly influenced by changes in the position of the Intertropical Convergence Zone (ITCZ). Conditioning by ITCZ migration of the tropical Pacific Ocean towards salinity increase during YD and HS1, and the subsequent advection of those water masses as far north as 25°N likely accounted for the reconstructed hydrographical changes at the SLB. A larger influence of tropical water masses as far north as 25°N plausibly contributed to changes in the atmospheric moisture transports to western North America and affected the regional hydrological cycle across T1. Finally, the fine-scale resolution of our δ18OSW-IVC record allows pinpointing a shift from relative salty to fresh surface conditions at ~16.2 ka, signaling that the two-phase structure of HS1 is plausibly a ubiquitous feature of the northern tropical to extratropical ocean-atmosphere dynamics. Key Points California Current weakening at 25ºN during T1Tropical-Northeast Pacific salinification during North Atlantic cold episodesTwo phases of Heinrich Stadial 1 in the 18OSW-IVC record ©2013. American Geophysical Union. All Rights Reserved.


News Article | April 4, 2016
Site: news.yahoo.com

Pendulum clocks made by Mexican clock manufacturer Relojes Centenario were used to investigate the mechanisms behind synchronization. More The 350-year-old mystery of why pendulum clocks hanging from the same wall can influence each other and synchronize over time may hold even more secrets than previously thought, researchers say. Solving this mystery could shed light on puzzling aspects of a variety of synchronized behaviors, such as how brain cells work together, the scientists added. In 1665, the inventor of the pendulum clock, Dutch physicist Christiaan Huygens, was lying in bed sick, watching two of his clocks, when he noticed something odd: No matter how the pendulums on these clocks started, they ended up swinging in exactly the opposite direction from each other within about a half-hour. [The 9 Biggest Unsolved Mysteries in Physics] For centuries, the cause of this effect was unknown. Solving the puzzle could help shed light on the mysterious phenomenon of synchronization, scientists say. "The synchronization phenomenon is one of the most pervasive drives in nature," said study lead author Jonatan Peña Ramirez, a dynamicist at the Center for Scientific Research and Higher Education in Ensenada, Mexico. "For example, consider a couple dancing to the rhythm of music, or violinists in an orchestra playing in unison, or a school of fish gracefully swimming." In a separate study published last year in the journal Scientific Reports, scientists suggested that the explanation for this phenomenon involved sound pulses traveling from clock to clock — for instance, through the wall on which the machines hang. However, Peña and his colleagues now suggest that Huygens' original explanation for this mystery could be the correct one. The researchers experimented with two complex pendulum clocks known as monumental clocks."To the best of our knowledge, this is the first time that Huygens' experiment is reproduced using real monumental pendulum clocks," Peña told Live Science. "Previous studies have used scaled-down versions of pendulum clocks, or commercial and generic clocks." The scientists placed both clocks on the same wooden table. As they expected, the motion of the clock pendulums synchronized over time. However, unlike the clocks in Huygens' experiment, the clocks did not swing in opposite directions. Rather, they unexpectedly moved in exactly the same direction. Moreover, while the clocks stayed in sync, they became slower and more inaccurate over time, the scientists said. To explain these findings, the researchers developed a mathematical model of the clocks, taking into account the flexible nature of the wooden support that both machines rested on. The model suggested that the clocks could make the wooden board vibrate. The researchers found that the support connecting the clocks (in this case, the wooden table) could serve as a kind of communication channel between the clocks, which they could use to exchange energy. The rigidity, thickness and mass of this support can influence the way in which the clocks synchronize and how inaccurate they become, the researchers said. [5 of the Most Precise Clocks Ever Made] Long ago, Huygens suggested that the synchronous behavior of the clocks he observed might be caused by "the imperceptible vibrations of the beam on which they are hanging," Peña said. Huygens "was so brilliant that he gave the correct explanation for his discovery without using a single equation." These findings suggest that much remains unknown about how coupled pendulum clocks behave, Peña said. "There still are hidden secrets to be revealed, and consequently, further studies of this system are necessary in order to unveil more details about the complex yet intriguing synchronization phenomenon," Peña said. A better understanding of synchronization could have technological and biological implications. For instance, consider two rotors mounted on an elastic support. "A familiar example of this kind of devices is a washing machine," Peña said. Under certain conditions, the rotors may synchronize to rotate in the same direction, or in opposite directions, he said. The synchronization of these rotors in opposite directions is highly desirable, because this will reduce or even eliminate the vibrations of the washing machine while its rotors are operating, Peña said. However, synchronization of these rotors in the same direction is not desired at all, because strong vibrations can result, with harmful and undesirable effects, he explained. "Something similar happens in living organisms," Peña said. "For instance, inside the human body, there are several biological rhythms — respiration, heartbeat and blood perfusion, just to mention a few of them. It has been found that when some of these rhythms synchronize with each other, the energy consumption is minimal; hence, in this case, the onset of synchronization is beneficial. On the other hand, synchronization can also be dangerous or detrimental; it is widely accepted that the process of seizure generation is closely associated with abnormal synchronization of neurons." The scientists detailed their findings online March 29 in the journal Scientific Reports. The clocks used in the experiments are now in a museum next to monumental clocks factory Relojes Centenario in Zacatlán, Mexico, where the clocks were made. Copyright 2016 LiveScience, a Purch company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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