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Bisgaard C.F.,Aarhus University Hospital | Bisgaard C.F.,Center for Psychiatric Research | Bak S.,University of Southern Denmark | Christensen T.,Aarhus University Hospital | And 3 more authors.
Journal of Psychopharmacology | Year: 2012

Extensive preclinical research has focused at unravelling the underlying molecular mechanisms leading to depression and recovery. In this study, we investigated the quantitative changes in protein abundance in the ventral hippocampal granular cell layer. We compared different phenotypes from the chronic mild stress (CMS) model of depression using chronic administration with two selective serotonin reuptake inhibitors (SSRIs), escitalopram and sertraline. We isolated granular cells using Laser-Capture Microdissection (LCM) and we identified their regulated proteins using two-dimensional (2D) differential gel electrophoresis (DIGE) and tandem mass spectrometry (MS/MS). The majority of the proteins we identified were enzymes involved in different metabolic activities. Additional proteins were functionally classified as vesicular proteins and immune system proteins. Rab GDP dissociation inhibitor alpha (GDIA) and syntaxin-binding protein 1 (STXB1) were potential markers for stress reactivity. Dynamin 1 (DYN1), glutathione S-transferase omega-1 (GSTO1) and peroxiredoxin (PRDX6) were associated with treatment response. In addition, an imbalance between different post-translationally modified versions of DYN1 and GSTO1 potentially accounted for SSRI treatment refraction. In the present study, we searched for new markers of stress reactivity and treatment response as well as any underlying molecular mechanisms correlating to the development of anhedonia and antidepressant therapy refraction. Our results pointed towards an essential role of post-translational modifications in both vesicular and immune protein systems. © The Author(s) 2012.

Coskun M.,Istanbul University | Ozturk M.,Center for Psychiatric Research
Dusunen Adam | Year: 2013

Sexual fetishism in adolescence: report of two cases Sexual fetishism is defined by recurrent, intense, sexually arousing fantasies, sexual urges or behaviors involving the use of nonliving objects, such as female undergarments or non-sexual body parts. Although it is assumed that fetishism usually begins by adolescence, there is very limited data on the characteristics of sexual fetishism in children or adolescents. This paper aims to describe clinical pictures of two adolescent boys who developed sexual fetishism. They were 13 and 12 years-old of age and both have comorbid attention deficit hyperactivity and social anxiety disorders. We plan to discuss clinical picture, treatment intervention and impact of comorbid attention deficit hyperactivity and social anxiety disorders in the development of sexual fetishism in these subjects.

Hastrup L.H.,Psychiatric Research Unit | Hastrup L.H.,Center for Psychiatric Research | Hastrup L.H.,Unit for Psychiatric Research | Aagaard J.,Psychiatric Research Unit
Nordic Journal of Psychiatry | Year: 2015

Purpose: Health economic evidence of assertive community treatment (ACT) in Denmark is limited. The aim of the study was to assess the costs and outcome of ACT among 174 patients with severe and persistent mental illness in a rural area of Denmark. Methods: The study was based on a quasi-experimental design with a control group from the neighbouring region. Costs and retention in mental health services were analysed by using register data 1 year before and 4 years after inclusion in the study. Data on the use of supportive housing were available for the year before baseline and the subsequent 2 years only. Results: Seventy eight percent of the patients receiving ACT were in contact with psychiatric services at the 4-year follow-up, while 69% of the patients in the control group had contact with psychiatric services (P < 0.17). Days in supportive housing were lower for the ACT group before baseline and remained so (dropping to zero) for the subsequent 2 years. Over 4 years, the mean total costs per patient in the group receiving ACT were DDK 493,442 (SE = 34,292). Excluding costs of supportive housing, the mean total costs per patient of the control group were DDK 537,218 (SE = 59,371), P < 0.53. If these costs are included, however, the mean total costs for the ACT group are unchanged, whereas costs for the control group rise to DDK 671,500 (SE = 73,671), P < 0.03. Conclusion: While ACT appears to have resulted in a significant reduction in costs for psychiatric hospitalizations, baseline differences in use of supportive housing make the effects of ACT on overall costs more ambiguous. At worst, however, overall costs did not increase. Given the generally acknowledged clinical benefits of ACT over standard outpatient care, the results support further dissemination of ACT in Denmark. © 2014 Informa Healthcare.

Coskun M.,Istanbul University | Zoroglu S.,Istanbul University | Ozturk M.,Center for Psychiatric Research
Child and Adolescent Psychiatry and Mental Health | Year: 2012

Objective: The study aimed to investigate phenomenology, psychiatric comorbidity, and family history of obsessive-compulsive disorder (OCD) in a clinical sample of normally developing preschool children with OCD.Method: Subjects in this study were recruited from a clinical sample of preschool children (under 72 months of age) who were referred to a university clinic. Subjects with a normal developmental history and significant impairment related to OCD symptoms were included in the study. Children's Yale-Brown Obsessive-Compulsive Scale was used to assess OCD symptoms. Each subject was assessed for comorbid DSM-IV psychiatric disorders using a semi-structured interview. Parents were evaluated for lifetime history of OCD in individual sessions. Results: Fifteen boys and ten girls (age range: 28 to 69 months; 54.12±9.08 months) were included. Mean age of onset of OCD was 35.64±13.42 months. All subjects received at least one comorbid diagnosis. The most frequent comorbid disorders were non-OCD anxiety disorders (n=17; 68.0%), attention-deficit hyperactivity disorder (ADHD) (n=15; 60.0%), oppositional defiant disorder (ODD) (n=12; 48.0%), and tic disorders (n=6; 24.0%). Mean number of comorbid disorders was 3.65 and 2.35 for boys and girls, respectively. At least one parent received lifetime OCD diagnosis in 68 percent of the subjects. Conclusions: The results indicated that OCD in referred preschool children is more common in males, highly comorbid with other psychiatric disorders, and associated with high rates of family history of OCD. Given the high rates of comorbidity and family history, OCD should be considered in referred preschool children with disruptive behavior disorders and/or with family history of OCD. © 2012 Coskun et al.; licensee BioMed Central Ltd.

Dahl K.,Center for Psychiatric Research | Schou M.,Center for Psychiatric Research | Schou M.,Astrazeneca | Amini N.,Center for Psychiatric Research | Halldin C.,Center for Psychiatric Research
European Journal of Organic Chemistry | Year: 2013

The palladium-catalyzed [11C]carbonylation of aryl halides and triflates was achieved at atmospheric pressure by employing xantphos as the supporting ligand. Aryl halides were converted into their corresponding [ 11C]amides in good to excellent yields. The conditions were also successfully employed in the radiolabeling of an [11C]ester, a [ 11C]carboxylic acid, an [11C]aldehyde, and a [ 11C]ketone. The palladium-catalyzed [11C]carbonylation of aryl halides and triflates was achieved at atmospheric pressure by employing xantphos as the supporting ligand. Aryl halides were converted into their corresponding [11C]amides in good to excellent yields. The conditions were also successfully employed in the radiolabeling of an [ 11C]ester, a [11C]carboxylic acid, an [ 11C]aldehyde, and a [11C]ketone. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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