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Yang L.-Q.,Center for Prevention and Control of Diseases | Li L.,Center for Prevention and Control of Diseases | Zhang N.,Center for Prevention and Control of Diseases | Jia B.,Center for Prevention and Control of Diseases | And 2 more authors.
Chinese Journal of Biologicals | Year: 2015

Objective To analyze the effect of two dose immunization schedule of varicella vaccine on the incidence of varicella in Chaoyang District, Beijing City, China. Methods After the implementation of two dose of immunization schedule of varicella vaccine, the data on varicella cases occurred in Chaoyang District during 2010 ∼ 2014 were analyzed by descriptive epidemiological method. Results The incidences in children at ages of 4 ∼ 12 years in 2013 and 2014 decreased by 73.41% than those in 2010 and 2011, while those in the populations at ages of less than 4 years and more than 12 years decreased by 18.75%. The ratio of incidence in children at ages of 4 ∼ 12 years decreased from 48.33% in 2010 and 2011 to 29.09% in 2013 and 2014. The sales volume of varicella vaccine in 2014 was 85 752 doses, which increased by 1.19 folds as compared with the mean sales volume in 2010 and 2011. The incidence showed a decreasing tendency with the increasing sales volume. The case number and outbreak of varicella in 2013 and 2014 decreased as compared with those in 2010 and 2011. More than 50% of the total cases had history of immunization, in which the proportion of breakthrough cases was higher than that of commom cases. Conclusion The two dose immunization schedule of varicella vaccine decreased the total incidence of varicella, of which the effect was superior to that of one dose immunization schedule. Source

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