Center for Pharmaceutical science

Hyderabad Andhra Pradesh, India

Center for Pharmaceutical science

Hyderabad Andhra Pradesh, India
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Macharla S.P.,Sri Indu Institute of Pharmacy | Goli V.,Venkateshwara Institute of Pharmaceutical science | Sattla S.R.,Center for Pharmaceutical science
Journal of Chemical and Pharmaceutical Research | Year: 2012

The different solvent extracts of Raphanus Sativus L. leaves (Family: Brassicaceae) were tested for antidiabetic activity using alloxan induced diabetic rats and compared with standard. The results expressed that aqueous extracts had shown significant protection and maximum reduction in blood glucose was observed in alloxan induced diabetic rats (p<0.001). The results of this comprehensive study reveal that R. sativus L leaves showed statistically significant Antidiabetic activity in comparison to the standard glibenclamide.

Srikanth S.,Center for Pharmaceutical science | Mohan G.K.,Center for Pharmaceutical science
Pharma Research | Year: 2013

Nootropics are "smart drugs" that improve mental functions such as memory, intelligence, motivation, attention, concentration. Cognitive enhancement may be defined as the amplification core capacity of the brain through improving the information processing systems. Memory disabilities are a spectrum of disorders like Alzheimer's disease, Corticobasal Degeneration Creutzfeldt-Jakob Disease, Fronto-temporal Dementia, Huntington's disease, Lewy Body Dementia, Mild Cognitive Impairment, Progressive Supranuclear, Palsy, Vascular Dementia etc., and affecting people from years ago. Traditional system of herbal medicinal plants has been used to improve memory and cognitive function and to treat neurodegenerative diseases. This review will help to get an idea about the natural plants that have been tested for their nootropic potential.

Ajitha M.,Center for Pharmaceutical science | Rajnarayana K.,Glukem Pharmaceutical P Ltd
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Forty five New 3-substituted [3,4-dihydropyrimidinones]-Indolin-2-ones have been synthesized and tested for in vitro cytotoxic activity against CHO cell lines and MCF-7 cell lines by MTT method.Of them compounds AJ31, AJ32, AJ25, AJ22 and AJ21 exhibited greater cytotoxic activity.The compounds were more sensitive to CHO cell lines compared to MCF-7 cell lines However,some of the compounds exhibited similar cytotoxic activities to that of standard cisplatin.

Reddy S.,Center for Pharmaceutical science | Sanganabhatla D.,Center for Pharmaceutical science | Himabindhu I.,Center for Pharmaceutical science
International Journal of Research in Pharmaceutical Sciences | Year: 2011

Transdermal patches offer a convenient way to administer drugs without the drawbacks of injections and oral dosage forms. However, the stratum corneum allows only low molecular weight drugs to diffuse through and acts as a barrier that limits the penetration of drug substances through the skin. Recently, the use of microneedles for skin permeability has been proposed and shown to dramatically increase transdermal delivery. Microneedles are long and robust enough to penetrate across the barrier, but short enough to prevent nerve stimulation which pro-jections of solid silicon or hollow drug-filled metal needles which are fabricated in several shapes and sizes. With the use of hollow microneedles it allows the delivery of medicines, insulin, proteins, or nanoparticles that would encapsulate a drug or demonstrate the ability to deliver a virus for vaccinations. Microneedle use is simple, pain-free, and causes no bleeding, with further advantages of convenient manufacture, distribution, and disposal. © JK Welfare & Pharmascope Foundation.

Sunitha Reddy B.,Center for Pharmaceutical science | Aruna Jyothi S.,Center for Pharmaceutical science | Navatha A.,Center for Pharmaceutical science
International Journal of Drug Delivery | Year: 2014

Candesartan is primarily used as Anti-Hypertensive which is poorly soluble drug. It is available as salt form of cilexetil i.e., Candesartan cilexetil included under class II of Biopharmaceutical classification system whose bioavailability is 15%.The aim of the study is to enhance the solubility of the Candesartan cilexetil using inclusion complexation technique with β-CD as complexing agent. The complexation is evaluated both in liquid and solid state. The phase solubility profiles in different media (Millipore water, O.1N HCl, PBS 7.4) showed AL- type. Binary Mixtures of Candesartan cilexetil with CDs were prepared in the different ratios of 1molar experimentally with three different techniques (Physical Mixture, Kneading method, co-evaporation method). The complexes were analyzed using Fourier transform infrared spectroscopy and X-Ray diffractometery. From the analysis the complexation was confirmed in the co-evaporation and kneading method. Invitro studies were performed for all the ratios prepared by different methods in order to define the most appropriate ratio and preparation method. The percentage drug release from different mixtures, Marketed product and API is given as follows: Co evaporated Mixture > Kneaded Mixture > > >Physical Mixture‘ Marketed >API. © 2014, Advanced Research Journals. All rights reserved.

Mahesh C.,Vaagdevi Pharmacy College | Rani S.S.,Center for Pharmaceutical science
Journal of Chemical and Pharmaceutical Sciences | Year: 2015

Synthesis of 1-[2-Substituted hydrazine carbothioamido]-4-benzyl piperazines IV a-j was carried out by reacting Methyl 2-substituted hydrazine carbodithioate II a-j with piperazine in ethanol, finally 1-[2-substituted hydrazine carbodithioamido] piperazines III a-j with required benzyl chloride in presence of propanol to produce title compounds.All the title compounds IV a-j were screened for possible anti-bacterial activity against P.vulgaris, S.aureas, E.coli, B.subtillus and anti-fungal activity against Altenaria, Culvalaria, C. albicans and A. Niger. Among the compounds synthesized IVc, IVd and IVh demonstrated good antibacterial activity, IVb, IVf, and IVg showed good antifungal activity. The activities of the synthesized compounds are compared with the standardl and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral data.

Reddy M.S.,Center for Pharmaceutical science | Navatha A.,Center for Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2013

The aim of the present study is to evaluate the gum Dikamali as a sustained release polymer employing zidovudine as a model drug. Natural gums are economic, easily available and found useful as Pharmaceutical excipients. To the best of our knowledge, no significant work has been reported on dikamali. Zidovudine was received as a gift sample from Hetero Drugs Private limited (Jeedimetla, Hyderabad), Dikamali was received as a gift sample from Girijen Co-operative Corporation (Vishakapatnam). All the other chemicals used for the study are of Commercial grade. Zidovudine Matrix Tablets were prepared by Direct compression technique using dikamali. The prepared tablets were evaluated for Tapped density, Bulk density, Compressibility index, Hausner ratio, Angle of repose, Hardness, Friability, Weight variation, Thickness, Content uniformity. All the parameters were found to be within the limits. Dissolution studies performed for 10 different formulations containing Dikamali as a sustained release polymer in different concentrations like 10%, 15%, 20%, 25%, 30% with and without disintegrant. These Studies revealed that Dikamali at 30% concentration with disintegrant shows better sustaining property. The optimized formulation also subjected to different Kinetic models and it was shown that the formulation follows Higuchi model and from that it was concluded that the rate controlling mechanism is Diffusion. From the Korsmeyer Peppas equation it was found that drug release follows super case II transport. Future scope of this project is to use Dikamali as a binder for preparation of Zidovudine sustain release tablets.

Reddy S.,Center for Pharmaceutical science | Katyayani T.,Center for Pharmaceutical science | Navatha A.,Center for Pharmaceutical science | Ramya G.,Center for Pharmaceutical science
International Journal of Research in Pharmaceutical Sciences | Year: 2011

In modern drug discovery techniques, there has been a consistent increase in the number of poor water soluble drug candidate compounds, and currently more than 50% of new pharmacologically active chemical entities are lipophilic and exhibit poor water solubility. Self-micro emulsifying drug delivery (SMEDDS) is the one of the method for the improvement of oral bioavailability. SMEDDS are the isotropic mixtures of oils, surfactants, solvents and co-solvents. This review article tries to describe the formulation of SMEDDS and also talks about the construction of the phase diagram for SMEDDS. It describes the mechanism involved in self emulsification and the bio-pharmaceutical aspects involved. The advantages of SMEDDS over conventional emulsions are listed. Some of the marketed preparations of SMEDDS are listed in detail. A few drug delivery systems which show the scope for usage of the SMEDDS are also described. © JK Welfare & Pharmascope Foundation.

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