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Hyderabad Andhra Pradesh, India

Mahesh C.,Vaagdevi Pharmacy College | Rani S.S.,Center for Pharmaceutical science
Journal of Chemical and Pharmaceutical Sciences | Year: 2015

Synthesis of 1-[2-Substituted hydrazine carbothioamido]-4-benzyl piperazines IV a-j was carried out by reacting Methyl 2-substituted hydrazine carbodithioate II a-j with piperazine in ethanol, finally 1-[2-substituted hydrazine carbodithioamido] piperazines III a-j with required benzyl chloride in presence of propanol to produce title compounds.All the title compounds IV a-j were screened for possible anti-bacterial activity against P.vulgaris, S.aureas, E.coli, B.subtillus and anti-fungal activity against Altenaria, Culvalaria, C. albicans and A. Niger. Among the compounds synthesized IVc, IVd and IVh demonstrated good antibacterial activity, IVb, IVf, and IVg showed good antifungal activity. The activities of the synthesized compounds are compared with the standardl and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral data. Source


Reddy M.S.,Center for Pharmaceutical science | Navatha A.,Center for Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2013

The aim of the present study is to evaluate the gum Dikamali as a sustained release polymer employing zidovudine as a model drug. Natural gums are economic, easily available and found useful as Pharmaceutical excipients. To the best of our knowledge, no significant work has been reported on dikamali. Zidovudine was received as a gift sample from Hetero Drugs Private limited (Jeedimetla, Hyderabad), Dikamali was received as a gift sample from Girijen Co-operative Corporation (Vishakapatnam). All the other chemicals used for the study are of Commercial grade. Zidovudine Matrix Tablets were prepared by Direct compression technique using dikamali. The prepared tablets were evaluated for Tapped density, Bulk density, Compressibility index, Hausner ratio, Angle of repose, Hardness, Friability, Weight variation, Thickness, Content uniformity. All the parameters were found to be within the limits. Dissolution studies performed for 10 different formulations containing Dikamali as a sustained release polymer in different concentrations like 10%, 15%, 20%, 25%, 30% with and without disintegrant. These Studies revealed that Dikamali at 30% concentration with disintegrant shows better sustaining property. The optimized formulation also subjected to different Kinetic models and it was shown that the formulation follows Higuchi model and from that it was concluded that the rate controlling mechanism is Diffusion. From the Korsmeyer Peppas equation it was found that drug release follows super case II transport. Future scope of this project is to use Dikamali as a binder for preparation of Zidovudine sustain release tablets. Source


Srikanth S.,Center for Pharmaceutical science | Mohan G.K.,Center for Pharmaceutical science
Pharma Research | Year: 2013

Nootropics are "smart drugs" that improve mental functions such as memory, intelligence, motivation, attention, concentration. Cognitive enhancement may be defined as the amplification core capacity of the brain through improving the information processing systems. Memory disabilities are a spectrum of disorders like Alzheimer's disease, Corticobasal Degeneration Creutzfeldt-Jakob Disease, Fronto-temporal Dementia, Huntington's disease, Lewy Body Dementia, Mild Cognitive Impairment, Progressive Supranuclear, Palsy, Vascular Dementia etc., and affecting people from years ago. Traditional system of herbal medicinal plants has been used to improve memory and cognitive function and to treat neurodegenerative diseases. This review will help to get an idea about the natural plants that have been tested for their nootropic potential. Source


Reddy S.,Center for Pharmaceutical science | Katyayani T.,Center for Pharmaceutical science | Navatha A.,Center for Pharmaceutical science | Ramya G.,Center for Pharmaceutical science
International Journal of Research in Pharmaceutical Sciences | Year: 2011

In modern drug discovery techniques, there has been a consistent increase in the number of poor water soluble drug candidate compounds, and currently more than 50% of new pharmacologically active chemical entities are lipophilic and exhibit poor water solubility. Self-micro emulsifying drug delivery (SMEDDS) is the one of the method for the improvement of oral bioavailability. SMEDDS are the isotropic mixtures of oils, surfactants, solvents and co-solvents. This review article tries to describe the formulation of SMEDDS and also talks about the construction of the phase diagram for SMEDDS. It describes the mechanism involved in self emulsification and the bio-pharmaceutical aspects involved. The advantages of SMEDDS over conventional emulsions are listed. Some of the marketed preparations of SMEDDS are listed in detail. A few drug delivery systems which show the scope for usage of the SMEDDS are also described. © JK Welfare & Pharmascope Foundation. Source

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