Maine Center for Outcomes Research and Evaluation

Portland, ME, United States

Maine Center for Outcomes Research and Evaluation

Portland, ME, United States
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Wax J.R.,Maine Medical Center | Lucas F.L.,Maine Center for Outcomes Research and Evaluation | Lamont M.,Maine Medical Center | Pinette M.G.,Maine Medical Center | And 2 more authors.
American Journal of Obstetrics and Gynecology | Year: 2010

Objective: We sought to systematically review the medical literature on the maternal and newborn safety of planned home vs planned hospital birth. Study Design: We included English-language peer-reviewed publications from developed Western nations reporting maternal and newborn outcomes by planned delivery location. Outcomes' summary odds ratios with 95% confidence intervals were calculated. Results: Planned home births were associated with fewer maternal interventions including epidural analgesia, electronic fetal heart rate monitoring, episiotomy, and operative delivery. These women were less likely to experience lacerations, hemorrhage, and infections. Neonatal outcomes of planned home births revealed less frequent prematurity, low birthweight, and assisted newborn ventilation. Although planned home and hospital births exhibited similar perinatal mortality rates, planned home births were associated with significantly elevated neonatal mortality rates. Conclusion: Less medical intervention during planned home birth is associated with a tripling of the neonatal mortality rate. © 2010 Mosby, Inc. All rights reserved.


PubMed | Maine Medical Center and Maine Center for Outcomes Research and Evaluation
Type: Journal Article | Journal: Journal of clinical ultrasound : JCU | Year: 2016

To determine the relationship between the first-trimester chorionic bump and fetal aneuploidy.This retrospective cohort study included all singleton pregnancies with chromosomal analysis and sonographic examination performed between 5 0/7 and 13 6/7 weeks from January 1, 2010 through August 15, 2015. Interobserver and intraobserver agreement for identifying a chorionic bump was evaluated by the Kappa statistic. Pregnancies with and without a chorionic bump were compared regarding patient characteristics and fetal karyotypes.Six hundred ninety subjects were included, 16 (2.3%) having a bump. The kappa coefficients for interobserver agreement were 0.88 (95% confidence interval [CI]: 0.71-1.00) and 0.94 (95% CI: 0.82-1.00); those for intraobserver agreement were 0.81 (95% CI: 0.61-1.00) and perfect agreement. One hundred seventeen fetuses (16.9%) were aneuploid, of which five (4.3%) had a bump. The odds of aneuploidy in the presence of a chorionic bump were higher than those in the absence of a chorionic bump, although this difference was not statistically significant (odds ratio [OR] 2.3, 95% CI: 0.8-6.7). In subgroup analyses, odds of aneuploidy were four times higher in the bump group than in the no bump group among those with a sonographically isolated bump (OR 4.5, 95% CI: 1.5-13.5) and 15 times higher among those with an isolated bump and increased first-trimester aneuploidy risk (OR 15.0, 95% CI 2.4-93.3).Agreement in identifying chorionic bumps is near-perfect. A sonographically nonisolated chorionic bump is not associated with significant additional aneuploidy risk, whereas a sonographically isolated chorionic bump confers a significantly increased likelihood of aneuploidy in high-risk fetuses. 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:3-7, 2017.

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