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Belgrade, Serbia

Jankovic M.M.,University of Belgrade | Odalovic S.,Center for Nuclear Medicine | Popovic D.B.,University of Belgrade
2013 21st Telecommunications Forum Telfor, TELFOR 2013 - Proceedings of Papers | Year: 2013

The classification criteria for Sjögren's syndrome includes the salivary gland scintigraphy (SGS) as one of objective tests for assessment of salivary gland function. We have developed the software for the automatic calculation of commonly investigated quantitative salivary and oral indices (maximum accumulation, maximum secretion, modified secretion velocity, uptake ratio, parotid : submandibular ratio, ejection fraction, pre-stimulatory and post-stimulatory oral activity) derived from dynamic SGS. Our software enables the standardization of processing protocols in multicenter studies. © 2013 IEEE.

Hussain Z.,University of Punjab | Elahi S.,Center for Nuclear Medicine
Anaesthesia, Pain and Intensive Care | Year: 2012

Hypothyroidism is a common disorder affecting the cardiovascular, respiratory, hematopoietic, and renal organ systems. Each of these systems is particularly relevant in the management of the surgical patient. Most reported complications have occurred in patients with unrecognized hypothyroidism. In general, treatment of recognized hypothyroidism is recommended before any surgical procedure whenever possible and normal levels of thyroid hormone should be documented as part of the preoperative evaluation. Such a strategy is likely to result in better surgical outcomes with improved morbidity and mortality.

Rasheed H.,University of Engineering and Technology Lahore | Elahi S.,Center for Nuclear Medicine | Ajaz H.,University of Engineering and Technology Lahore
Biological Trace Element Research | Year: 2012

This study was conducted to determine the prevalence of hypomagnesemia and its effect on the lipid profile of local type II diabetic patients. For this purpose, 219 diabetic patients and 100 age-matched control subjects were enrolled. Blood samples of the subjects were analyzed for fasting glucose, Mg, triglyceride, total cholesterol, HDL-cholesterol, and LDL-cholesterol. Results showed that mean serum values of these parameters were differing in diabetic patients as compared to control subjects. The reference range of serum magnesium in healthy controls was 1.2-4.4 mg/dl. Mean serum magnesium in diabetic patients was significantly lower as compared to healthy subjects (1.6±0.23 mg/dl vs. 2.8 ±0.8 mg/dl). Among diabetic patients, 143 (65.3%) had serum magnesium level below 1.7 mg/dl (hypomagnesemia). The corresponding figure for control subjects was 11 (11%). The difference was significant (p<0.01).Diabetesmellitus patients with current hyperglycemic status had significantly lower serum Mg as compared to euglycemic patients (p=0.05). Serum Mg in diabetic patients was correlated with all lipid parameters. Among them, HDL-cholesterol was significantly (p<0.05) positively correlated (r=0.34), while total cholesterol and LDL-cholesterol was negatively correlated, albeit nonsignificantly, with serum Mg. These results demonstrate that hypomagnesemia is accompanied by atherogenic alterations in the lipid profiles of type II diabetic patients of Lahore, Pakistan. © Springer Science+Business Media, LLC 2012.

Akhtar M.S.,Bahawalpur Institute of Nuclear Medicine and Oncology BINO | Kousar F.,Center for Nuclear Medicine | Masood M.,Institute of Nuclear Medicine and Oncology INMOL | Fatimi S.,Bahawalpur Institute of Nuclear Medicine and Oncology BINO | Kokab,Bahawalpur Institute of Nuclear Medicine and Oncology BINO
Journal of the College of Physicians and Surgeons Pakistan | Year: 2010

Objective: To compare the results of patients with locally advanced breast cancer receiving two different regimens Fluorouracil, Doxorubicin and Cyclophosphamide (FAC) and Paclitaxel and Carboplatin. Study Design: Comparative study. Place and Duration of Study: The Oncology Department, Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from March 2007 to September 2008. Methodology: Patients with inoperable locally advanced breast cancer of stage were included. Sixteen patients were given FAC regimen and 9 patients were given Paclitaxel and Carboplatin, each combination was cycled after 21 days for four times. Before enrollment, detailed medical histories, physical examinations and performance status assessments were done as well as postchemotherapy evaluation with regular follow-up visits was done. Complete Response (CR, ↓100%) is defined as the disappearance of all known disease parameter i.e. disappearance in detectable tumour size, node free disease and surgery is possible. Paratial Response (PR, ↓ > 50%) was defined by 50% or greater decrease in the sum of the areas of bidimensionally measured lesions i.e. change of N2 to N1 or no status and some surgical procedure is possible to downstage the disease. Minor Response (MR) was defined as a decrease in the tumour insuffieceint to quality for partial responce. Static disease or no evaluable reflected no significant change in disease and no evidence of new disease. Progression of disease (> 25%) was defined as a 25% or greater increase in the area of any lesion > 2 cm or in the sum of the products of the individual lesions or the apprearance of new malignant lesions, surgery not possible. Results: Twenty five patients completed neoadjuvant chemotherapy. Sixteen (66%) patients received FAC and 9 (37%) patients received PC chemotherapy. Overall CR (breast and axilla) was 54%, PR was 16% and minor response (MR) was 8%. FAC treatment induced more emesis, mucositis, alopecia and cardiotoxicity. No death occurred. Conclusion: The Paclitaxel and Carboplatin regimen was better tolerated; both regimens were effective in improving disease and overall survival. © 2010. College of Physicians & Surgeons Pakistan.

Trifunovic D.,University of Belgrade | Sobic-Saranovic D.,University of Belgrade | Sobic-Saranovic D.,Center for Nuclear Medicine | Beleslin B.,University of Belgrade | And 13 more authors.
International Journal of Cardiovascular Imaging | Year: 2014

Coronary microcirculatory function after primary percutaneous coronary intervention (pPCI) in patients with acute myocardial infarction is important determinant of infarct size (IS). Our aim was to investigate the utility of coronary flow reserve (CFR) and diastolic deceleration time (DDT) of the infarct artery (IRA) assessed by transthoracic Doppler echocardiography after pPCI for final IS prediction. In 59 patients, on the 2nd day after pPCI for acute anterior myocardial infarction, transthoracic Doppler analysis of IRA blood flow was done including measurements of CFR, baseline DDT and DDT during adenosine infusion (DDT adeno). Killip class, myocardial blush grade, resolution of ST segment elevation, peak creatine kinase-myocardial band and conventional echocardiographic parameters were determined. Single-photon emission computed tomography myocardial perfusion imaging was done 6 weeks later to define final IS (percentage of myocardium with fixed perfusion abnormality). IS significantly correlated with CFR (r = −0.686, p < 0.01), DDT (r = −0.727, p < 0.01), and DDT adeno (r = −0.780, p < 0.01). CFR and DDT adeno in multivariate analysis remained independent IS predictors after adjustment for other covariates and offered incremental prognostic value in models based on conventional clinical, angiographic, electrocardiographic and enzymatic variables. In predicting large infarction (IS > 20 %), the best cut-off for CFR was <1.73 (sensitivity 65 %, specificity 96 %) and for DDT adeno ≤720 ms (sensitivity 81 %, specificity 96 %). CFR and DDT during adenosine are independent and powerful early predictors of final IS offering incremental prognostic information over conventional parameters of myocardial and microvascular damage and tissue reperfusion. © 2014, Springer Science+Business Media Dordrecht.

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