Center for New Antivirals and Antineoplastics

Hradec Králové, Czech Republic

Center for New Antivirals and Antineoplastics

Hradec Králové, Czech Republic
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Schiller R.,Center for New Antivirals and Antineoplastics | Tichotova L.,Center for New Antivirals and Antineoplastics | Pavlik J.,Center for New Antivirals and Antineoplastics | Buchta V.,Charles University | And 5 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2010

A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells. © 2010 Elsevier Ltd. All rights reserved.

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