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Plackal George B.,Bharathiar University | Thangaraj P.,Bharathiar University | Sulaiman C.,Center for Medicinal Plants Research | Piramanayagam S.,Bharathiar University | Ramaswamy S.K.,Bharathiar University
BioMed Research International | Year: 2014

The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of using R. fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases. © 2014 Blassan Plackal George et al. Source


Rajani J.,Kerala University | Deepu V.,Center for Medicinal Plants Research | Nair G.M.,Central University of Kerala | Nair A.J.,Kerala University
International Food Research Journal | Year: 2013

Random Amplified Polymorphic DNA (RAPD) analysis was performed to assess the genetic diversity in ten selected cultivars of rice, Oryza sativa L. using 30 decamer random primers. Out of 30, 25 RAPD primers revealed polymorphism while the remaining 5 primers showed no reaction. The primers produced a total of 428 bands of which 363 were polymorphic (85.02%). The number of polymorphic fragments for each primer varied from 7 to 23 with an average of 14 polymorphic fragments. The primer OPB-17 produced the maximum number of polymorphic bands. The RAPD data was analyzed to determine the genetic similarity coefficients which ranged from 0.46 to 0.81. Cluster analysis was performed using Unweighted Paired Group of Arithmetic Means (UPGMA) using the Jaccard's similarity coefficient. The UPGMA dendrogram resolved the selected rice cultivars into two major clusters. Source


Sulaiman C.T.,Center for Medicinal Plants Research | Nasiya K.K.,Sree Sankara College | Balachandran I.,Center for Medicinal Plants Research
Spectroscopy Letters | Year: 2016

Acacia leucophloea is a medicinal plant used traditionally for treating many diseases. In the present study, phytochemicals were isolated from the bark of A. leucophloea using multiple chromatographic techniques. The separation and isolation were done using column chromatography. The molecular masses of isolated compounds were assigned by electro spray ionization mass spectrometry. The subsequent structure characterization was carried out by a tandem mass spectrometric method. Fragmentation behavior of compounds was investigated using hexapole collision cell mass spectrometry in negative mode. Six phenolic compounds such as catechin, leuco-fisetinidin, gallic acid, ferulic acid, syringic acid, and O-methyl epicatechin were identified. Most of the compounds identified are first report from this plant. © 2016 Taylor & Francis. Source


Sulaiman C.T.,Center for Medicinal Plants Research | Sulaiman C.T.,Karpagam University | Gopalakrishnan V.K.,Karpagam University | Balachandran I.,Center for Medicinal Plants Research
International Journal of Phytomedicine | Year: 2012

rapid method was developed for the identification of phenolics from Acacia Catechu. The analysis of phenolic compounds was carried out by reversed-phase high-performance liquid chromatography (RPHPLC) coupled to electrospray ionization-time-of-flight mass spectrometry (ESI-Q-TOF-MS). The accurate mass data for the molecular ions were processed using the software Mass Hunter work station (Agilent Technologies), which provided a list of possible elemental formulas by using the Molecular featured extraction editor. The subsequent structure characterization was carried out by a tandem mass spectrometric method. Fragmentation behavior of phenolic compounds was investigated using ion trap mass spectrometry in negative mode. The total fragmentation of the compound ion leading to other fragments was corroborated by MS-MS. Five phenolic compounds have been identified from the methanolic extract of Acacia Catechu. Source


Anilkumar K.A.,Center for Medicinal Plants Research | Prabhu Kumar K.M.,Center for Medicinal Plants Research | Udayan P.S.,P.A. College
Taiwania | Year: 2015

A new species of Gentianaceae, Gentiana kurumbae is described from the Attappady hills of Palakkad district, Kerala State, India. A detailed description, information on habitat, distribution, phenology, relevant taxonomic and ecological notes are provided along with photographs and illustration. This species resembles Gentiana pedicellata var. wightii, but by having an erect and unbranched habit, ca. 15 mm long, broadly ovate-elliptic and chartaceous leaves with apiculate apex and serrulate margin. Gentiana kurumbae is characterized by bright blue flowers with very short pedicels up to 3 mm long, scabrous and linear-oblong to oblanceolate bracts with apiculate apex, acute calyx and corolla lobes with apiculate apex and stamens with filiform or minutely thickened filaments towards base. Source

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