Center for Materials Characterization

Pune, India

Center for Materials Characterization

Pune, India
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Ormes J.D.,Merck And Co. | Zhang D.,Merck And Co. | Chen A.M.,Merck And Co. | Chen A.M.,Center for Materials Characterization | And 4 more authors.
Pharmaceutical Development and Technology | Year: 2013

There has been a growing interest in amorphous solid dispersions for bioavailability enhancement in drug discovery. Spray drying, as shown in this study, is well suited to produce prototype amorphous dispersions in the Candidate Selection stage where drug supply is limited. This investigation mapped the processing window of a micro-spray dryer to achieve desired particle characteristics and optimize throughput/yield. Effects of processing variables on the properties of hypromellose acetate succinate were evaluated by a fractional factorial design of experiments. Parameters studied include solid loading, atomization, nozzle size, and spray rate. Response variables include particle size, morphology and yield. Unlike most other commercial small-scale spray dryers, the ProCepT was capable of producing particles with a relatively wide mean particle size, ca. 2-35 μm, allowing material properties to be tailored to support various applications. In addition, an optimized throughput of 35 g/hour with a yield of 75-95% was achieved, which affords to support studies from Lead-identification/Lead-optimization to early safety studies. A regression model was constructed to quantify the relationship between processing parameters and the response variables. The response surface curves provide a useful tool to design processing conditions, leading to a reduction in development time and drug usage to support drug discovery. © 2013 Informa Healthcare USA, Inc.

Ruikar A.,Fergusson College Jr Section | Torane R.,P.A. College | Misar A.,Agharkar Research Institute | Mujumdar A.,Agharkar Research Institute | And 2 more authors.
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

Normal metabolism of our body generates harmful free radicals which are not neutralized by the body’s primary and secondary defense mechanisms. Research has demonstrated the role of antioxidants to protect the body from cell damage that can lead to cancer, heart diseases etc. Artocarpus heterophyllus belonging to family moraceae is an important medicinal plant. Many parts of the plant including the bark, roots, leaves, and fruit are attributed with medicinal properties. The present study was designed to investigate antioxidant potential of ethanol extract of bark material of the plant. DPPH radical scavenging assay and Superoxide radical scavenging assay were performed using ascorbic acid as standard. Hydroxy radical scavenging assay, Nitric radical assay and Hydrogen peroxide assay were studied with curcumin as standard. Reducing power assay was carried out with BHT as standard. Trolox Equivalent Antioxidant capacity was also investigated. IC50 values observed for DPPH, Trolox, Hydroxy radical scavenging assay, Hydrogen peroxide, Reducing power, Superoxide radical scavenging, Nitric radical assay were 40.81, 113.00, 60.14, 96.41, 50.50, 24.30, 52.76 µg/ml respectively. The results clearly indicate that the bark extract has the potential to be effective antioxidant. © 2015, Global Research Online. All rights reserved.

Kant M.B.,University of Pune | Shinde S.D.,University of Pune | Bodas D.,Agharkar Research Institute | Patil K.R.,Center for Materials Characterization | And 3 more authors.
Applied Surface Science | Year: 2014

This paper discusses microfabrication process for benzophenone doped polydimethylsiloxane (PDMS) using laser lithography. KrF excimer laser of 248 nm with 20 ns pulse width at repetition rate of 1 Hz was used for microfabrication of undoped and benzophenone doped PDMS. The doped-PDMS shows sensitivity below 365 nm, permitting processing under ambient light. The analysis of etch depth revealed that doped PDMS shows self developable sensitivity at lower fluence of ∼250 mJ/cm2. The unexposed and exposed surface was studied using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and Scanning electron microscopy (SEM). Spectrocopic analysis indicated increase in CO, CO, SiO3 and SiO4 bonding at the expense of SiC and SiO2 bonds of PDMS. In case of laser exposed doped-PDMS, removal of benzophenone from probe depth of spectroscopy was observed. Whereas the surface morphology of exposed and unexposed doped-PDMS was observed to be same, indicating clean development of PDMS micropatterns. The present study indicates that addition of 3.0 wt.% benzophenone in PDMS enhance self development sensitivity of PDMS. The self developable results on doped-PDMS are quite encouraging for its potential use in point of care Lab-On-Chip applications, for fabricating micropatterns using direct write laser lithography technology. © 2014 Elsevier B.V.

Das U.K.,Indian Association for The Cultivation of Science | Puranik V.G.,Center for Materials Characterization | Dastidar P.,Indian Association for The Cultivation of Science
Crystal Growth and Design | Year: 2012

Earlier studies revealed that primary ammonium dicarboxylate (PAD) salts possessed gelling ability, and many such salts displayed a 1D columnar hydrogen bonded network (observed in primary ammonium monocarboxylate (PAM) salts) on either side of the dicarboxylate end of the anion. In the present study, a new series of diprimary ammonium monocarboxyate (DPAM) salts have been prepared with the aim of achieving supramolecular synthon transferability (the same 1D columnar hydrogen PAM bonded network on either side of the diammonium cation) in these salts. Single crystal X-ray diffraction studies revealed that, in 47% of the DPAM salts, such supramolecular synthon transferability indeed took place. Some of the DPAM salts also showed gelation ability. The gels were characterized by DSC, rheology, electron microscopy, and atomic force microscopy. Structure property correlation using single crystal and powder X-ray diffraction data on a selected gel was also attempted. © 2012 American Chemical Society.

Kale S.S.,CSIR - National Chemical Laboratory | Kunjir S.M.,CSIR - National Chemical Laboratory | Gawade R.L.,Center for Materials Characterization | Puranik V.G.,Center for Materials Characterization | And 2 more authors.
Chemical Communications | Year: 2014

This communication describes the influence of β-aminobenzenesulfonic acid (SAnt) on the conformational preferences of hetero foldamers. The designed (Aib-SAnt-Aib)n and (Aib-SAnt-Pro) n oligomers display a well-defined folded conformation featuring intramolecular mixed hydrogen bonding (7/11) and intra-residual (6/5) H-bonding interactions, respectively. © 2014 The Royal Society of Chemistry.

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